Results 141 to 150 of about 11,593,090 (249)

Esterified Cholesterol Conjugates Enable LNP‐Mediated mRNA Delivery to the Blood–Brain Barrier Following Intravenous Administration

Advanced Materials, EarlyView.
A cholesterol‐conjugated lipid library enabled the identification of a ligand‐free LNP platform for efficient mRNA delivery to brain endothelial cells via systemic administration. This platform achieves selective BBB targeting without disrupting barrier integrity, and enables modulation of neuroinflammation and vascular function without requiring trans‐
Zeru Tian, Xu Wang, Alexis Pacheco Benitez, Erick Guerrero, Yaou Duan, Jingwen Wei, Lukas Farbiak, Daniel J. Siegwart   +7 more
wiley   +1 more source

Lung transplantation in a low-volume center : the Antwerp University Hospital Experience

: The outcome of lung transplantation seems to be dependent on several significant additional risk factors that may negatively impact the 1- and/or 5-y survival such as prior lung surgery, performing a single lung transplant compared to a double lung ...
Wen, Wen, Verplancke, Veronique, Wittock, Anouk, Lauwers, Patrick, Lapperre, Therese, Hendriks, Jeroen, Verleden, Stijn, Yogeswaran, Suresh Krishnan, de Paep, Rudi, Verleden, Geert M., Wener, Reinier   +10 more
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Transient paradoxical dissociation of alveolar volume indices after single-lung transplantation in a patient with severe emphysema: A case report. [PDF]

Respir Med Case Rep
Sagai S, Murata M, Ishii A, Sato S, Sakanoue I, Saito Y, Nagao M.   +6 more
europepmc   +1 more source

Iterative Selection of DNA Nanostructures for Cellular Uptake

Advanced Materials, EarlyView.
DNA nanostructures are promising cell targeting delivery vehicles for therapeutics, but the targeting behavior is not fully understood. In this study, libraries of DNA nanostructures that can be amplified and sequenced are combined with cellular uptake as a selection pressure to iteratively refine DNA structures taken up in cells to better understand ...
Anjali Rajwar, Lisa Eichhorn, Jakub Palacka, Sandra Ly, Erik Benson   +4 more
wiley   +1 more source

Computed tomography-derived pulmonary blood volume distribution may be modifiable in asthma. [PDF]

ERJ Open Res
Mappanasingam AA, Friedlander Y, Sandhu E, Thakar A, Ragunayakam N, Radadia N, Kjarsgaard M, McDonough JE, Venegas Garrido C, Hambly N, Mukherjee M, Nair P, Svenningsen S.   +12 more
europepmc   +1 more source

Self‐Assembling Copolymers Encapsulating Single Endothelial Cells Induce Endogenous ECM Deposition and Vascular Regeneration

Advanced Materials, EarlyView.
This study presents the first demonstration of stable sub‐50‐micron single‐cell GPM vesicles fabricated through the intrinsic self‐assembly of an amphiphilic copolymer. Hierarchical assembly of cell containing GPM vesicles into microspheres enable tunable, sustained cell delivery with immune protection.
Viola B. Morris, Sangho Lee, Kalp Soni, Simon He, Matthew Huang, Dandan Chen, Dae Hoon Lee, Kyung Hee Kim, Seonggeon Cho, Laura Pencea, Divit Jain, Young‐Sup Yoon   +11 more
wiley   +1 more source

Exploratory CT-Based Assessment of Emphysema Burden in Smokers with Bipolar Disorder Receiving Lithium Treatment. [PDF]

Int J Chron Obstruct Pulmon Dis
Şimşek ŞM, Şimşek MH, Cörüt R, Helvacı Çelik FG, Tonkaz G, Kaya A, Takır S.   +6 more
europepmc   +1 more source

Photoacoustic Nanotagging for In Vivo Tracking and Optimization of Macrophage Immunotherapy in Solid Tumors

Advanced Materials, EarlyView.
Macrophage‐based immunotherapy for solid tumors is limited by poor tracking of cell localization and persistence. This study introduces nanotagged macrophages enabling near‐infrared photoacoustic imaging for real‐time monitoring. IFNγ‐conjugated tags enhance antitumor polarization without harming viability.
Seoyoon Song, Melissa Cadena, Myeongsoo Kim, Euisuk Chung, Jeungyoon Lee, Zlata Brushevich, Seonghun Shin, Paul S. Pelkowski, Stanislav Y. Emelianov   +8 more
wiley   +1 more source

Increasing Lipid Nanoparticle mRNA Copy Number Improves Transfection Potency

Advanced Materials, EarlyView.
As lipid nanoparticle (LNP) systems are the leading platform for in vivo nucleic acid delivery, improving transfection potency of these systems is of considerable interest. In this work, we explored a post‐mixing formulation method involving a two‐step buffer exchange that increased the number of mRNA copies within each LNP while reducing the number of
Yao Zhang, Jerry Leung, Judy Cheng, Arash Momeni, Albert Kamanzi, Ariadne Tuckmantel Bido, Suiyang Liao, Emma Kang, Colton Strong, Christian J. Kastrup, Sabrina Leslie, Miffy Hok Yan Cheng, Pieter R. Cullis   +12 more
wiley   +1 more source

Newfoundland Lung Association Newsletter; Lung Association of Newfoundland and Labrador Newsletter

, 1986
The Northern Light, Campaign 1986Message from the President -- 1986 Christmas Seal Design -- Christmas Seals Being Prepared -- Newfoundlanders Complete Terms at National Level -- Meet Clyde! -- West Coast Advisory Board Planning Full Year -- Dr.
Newfoundland Lung Association
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