Results 91 to 100 of about 288,873 (310)

Audiovestibular Dysfunction in Systemic Lupus Erythematosus Patients: A Systematic Review

Diagnostics
Audiovestibular dysfunction in patients with systemic lupus erythematosus has been underestimated for decades. Systemic lupus erythematosus can affect both the auditory and vestibular systems simultaneously.
Jiann-Jy Chen, Chih-Wei Hsu, Yen-Wen Chen, Tien-Yu Chen, Bing-Syuan Zeng, Ping-Tao Tseng   +5 more
doaj   +1 more source

Facets of lupus erythematosus: panniculitis responding to thalidomide

, 2008
Lupus erythematosus profundus or lupus panniculitis is a rare clinical variant of lupus erythematosus, which involves the deep dermis and subcutaneous fat. Diagnosis may be difficult in cases with isolated involvement.
Hunziker, Thomas, Wienert, Simone, Gadola, Stephan, Stephan Gadola, Thomas Hunziker, Simone Wienert, Wienert S, Hunziker T, Gadola, Stephan D., Gadola S   +9 more
core   +1 more source

Nano Proton Scavengers Modulate Endosomal pH to Inhibit Microglial Activation and Enhance Stroke Recovery

Advanced Science, EarlyView.
Amphiphilic sulfonated chitosan nanoparticles buffer endo/lysosomal acidity in microglia by limiting V‐ATPase membrane recruitment and restoring endosomal homeostasis. Following systemic administration, they accumulate in the ischemic hemisphere partly through association with infiltrating immune cells, suppress TLR3/IRF3 and TLR4/NF‐κB signaling ...
Xuanlin Wang, Yujing Shi, Zehua Gao, Jing Wang, Changsheng Liu   +4 more
wiley   +1 more source

Systemic lupus erythematosus in Europe at the change of the millennium: lessons from the "Euro-Lupus Project".

, 2006
The "Euro-Lupus Cohort" is composed by 1000 patients with systemic lupus erythematosus (SLE) that have been followed prospectively since 1991. These patients have been gathered by a European consortium--the "Euro-Lupus Project Group". This consortium was
Houssiau, Frédéric, Cosyns, Jean-Pierre, European Working Party on Systemic Lupus Erythematosus, Cervera, Ricard   +3 more
core   +1 more source

Macrophage RSAD2 Couples mtDNA Synthesis With a Self‐Amplifying Inflammatory Circuit to Orchestrate Tissue Repair

Advanced Science, EarlyView.
Macrophage RSAD2 dually regulates CMPK2—the rate‐limiting enzyme for mitochondrial DNA synthesis—by suppressing its ubiquitination and promoting its phosphorylation via Csnk2a2 recruitment. This amplifies mtDNA production, which simultaneously activates a cGAS‐STING‐IRF3‐RSAD2 feedforward loop and the NLRP3 inflammasome, driving a self‐sustaining ...
Haomiao Yuan, Shukui Du, Chunfei Li, Xinjie Li, Shuyang Mu, Anran Qu, Hengxu Yan, Chongchong Xu, Jinnong Yang, Jingkai Sun, Yijun Wang, Jiayang Xiao, Fuyuan Zhang, Linlin Wang, Tiegang Li, Rui Zhao, Dawei Guan   +16 more
wiley   +1 more source

An investigation of the molecular basis of interactions between human monoclonal antibodies and antigens that are clinically relevant in systemic lupus erythematosus and the Antiphospholipid Syndrome. [PDF]

, 2007
Autontibodies to a wide variety of antigens are associated with systemic lupus erythematosus (SLE) and the Antiphospholipid Syndrome (APS).
Lambrianides, A.
core  

Dysregulations in circulating sphingolipids associate with disease activity indices in female patients with systemic lupus erythematosus : a cross-sectional study

, 2017
Objective The objective of this study was to investigate the association of clinical and renal disease activity with circulating sphingolipids in patients with systemic lupus erythematosus.
Jakobsson, P-J, Nilsson, Peter,, Wheelock, C. E., Sar, D. Garcia, Surowiec, Izabella,, Checa, A., Idborg, H., Nilsson, P., Surowiec, I., Zandian, A., Zandian, Arash,, Gunnarsson, I., Trygg, J., Svenungsson, E., Trygg, Johan,, Trygg, J, Nilsson, P, Surowiec, I, Idborg, H,, Zandian, A, Gunnarsson, I,, Sar, DG, Svenungsson, E,, Checa, A   +23 more
core   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Acute acalculous cholecystitis in juvenile systemic lupus erythematosus

, 2015
Small- and medium-vessel vasculitis is a common manifestation in systemic lupus erythematosus (SLE) and may occur in any organ. However, acute acalculous cholecystitis is a rare abdominal manifestation in SLE, especially in children.
Appenzeller, S, Mendonca, JA, Prando, P, Marques-Neto, JF   +3 more
core   +2 more sources

Classifying discoid lupus erythematosus: background, gaps, and difficulties

International Journal of Women's Dermatology, 2016
To inform our ongoing efforts to develop defining features to be incorporated into a novel set of classification criteria for discoid lupus erythematosus (DLE), we conducted a literature review using the Ovid MEDLINE database.
Jessica S. Haber, BA, Joseph F. Merola, MD, MMSc, Victoria P. Werth, MD   +2 more
doaj   +1 more source