Results 71 to 80 of about 1,298 (98)

Abstract LB-C006: Scalable TCR synthesis and screening enable antigen reactivity mapping

Cancer immunology research
Mapping T cells to their antigenic targets is critical to developing new targeted cancer therapies but remains highly challenging at scale. Single-cell datasets capture thousands of T cell receptors (TCRs) from tumor-infiltrating T cells but offer ...
Stephanie A. Gaglione, Rachit S. Mukkamala, Chirag Krishna, Blake E. Smith, Marc H. Wadsworth, Caleb R. Perez, Laura Schmidt-Hong, Erica L. Katz, K. Gellatly, Lester R. Ali, Jiao Shen, Scott A. Jelinsky, P. Holec, Q. H. Zhao, Amanda O. Chan, Ellen J. K. Xu, K. Kravarik, J. Guzova, Connor S. Dobson, Harshabad Singh, Manuel Garber, Michael Dougan, Stephanie K. Dougan, John E. Harris, Aaron Winkler, Michael E. Birnbaum   +25 more
semanticscholar   +1 more source

Abstract 1587: Multimodal spatial transcriptomics uncover distinct tumor microenvironment states and cell-cell communication networks in molecular pancreatic cancer subtypes

Cancer Research
The tumor microenvironment (TME) presents a complex ecosystem comprising a diversity of immune and stromal cell populations that influence tumor progression, drug delivery and therapy outcome.
Stefanie Baerthel, Chiara Falcomatà, Vanessa Goelling, Daniele Lucarelli, R. Gindra, Constantin Schmitt, Jonathan J. Swietlik, Felix Meissner, M. Schmidt-Supprian, Dieter Saur   +9 more
semanticscholar   +1 more source

Abstract PR-13: Disruption of sulfatide metabolism by targeting UGT8 is an actionable metabolic vulnerability for pancreatic cancer early interception

Cancer Research
The existence of asymptomatic precursor lesions that are known to predate invasive pancreatic ductal adenocarcinoma (PDAC) by years provides a compelling rationale for cancer interception efforts.
R. Ballarò, Yihui Chen, F. Thege, Rongzhang Dou, Jimin Min, Michele T Yip-Schneider, Jianjun Zhang, Ranran Wu, E. Irajizad, Yuki Makino, K. Rajapakshe, M. Hurd, R. León-Letelier, E. Ostrin, J. Vykoukal, Jennifer B Dennison, Kim-Anh Do, Samir Hanash, R. Wolff, Paola A. Guerrero, Michael P Kim, C. Schmidt, Anirban Maitra, J. Fahrmann   +23 more
semanticscholar   +1 more source

Abstract 446: Integrated spatial transcriptomics and lipidomics analyses of intraductal papillary mucinous neoplasm identifies enrichment of long chain sulfatide as an early metabolic alteration

Cancer Research
Purpose: To define the metabolic alterations associated with malignant progression of intraductal papillary mucinous neoplasm (IPMN). Experimental Procedures: Matrix-assisted laser desorption/ionization (MALDI)-mass spectrometry (MS) was conducted for
Yihui Chen, Marta Sans, F. Thege, Rongzhang Dou, Jimin Min, Michele T Yip-Schneider, Jianjun Zhang, Ranran Wu, E. Irajizad, Yuki Makino, K. Rajapakshe, M. Hurd, R. León-Letelier, J. Vykoukal, Jennifer B Dennison, Kim-Anh Do, Robert A. Wolff, Paola A. Guerrero, Michael P Kim, Max Schmidt, Anirban Maitra, Samir M. Hanash, J. Fahrmann   +22 more
semanticscholar   +1 more source

Double tori solution to an equation of mean curvature and Newtonian potential

Calculus of Variations and Partial Differential Equations, 2014
Xiaofeng Ren, Juncheng Wei
semanticscholar   +2 more sources

Mastectomy or Margin Re-excision? A Nomogram for Close/Positive Margins After Lumpectomy for DCIS

Annals of Surgical Oncology, 2022
Catarina Martins Maia, C. Siderides, S. Jaffer, C. Weltz, S. Cate, Soojin Ahn, S. Boolbol, M. Ru, E. Moshier, E. Port, Hank Schmidt   +10 more
semanticscholar   +1 more source

Effects of heat and mass transfer on peristaltic flow in a non-uniform rectangular duct

, 2014
R. Ellahi, M. M. Bhatti, K. Vafai
semanticscholar   +1 more source

The Impact of Intraoperative Re-Resection of a Positive Bile Duct Margin on Clinical Outcomes for Hilar Cholangiocarcinoma

Annals of Surgical Oncology, 2018
Xufeng Zhang, M. H. Squires, F. Bagante, Cecilia G Ethun, A. Salem, S. Weber, T. Tran, G. Poultsides, A. Son, Ioannis S. Hatzaras, Linda X. Jin, R. Fields, M. Weiss, C. Scoggins, R. Martin, C. Isom, K. Idrees, H. Mogal, P. Shen, S. Maithel, C. Schmidt, T. Pawlik   +21 more
semanticscholar   +1 more source

Adaptive control-based Barrier Lyapunov Functions for a class of stochastic nonlinear systems with full state constraints

Automatica, 2018
Xinkai Chen, C P Chen, Dong-Juan Li
exaly  

Finite-time and fixed-time stabilization: Implicit Lyapunov function approach

Automatica, 2015
Andrey E Polyakov, Denis Efimov
exaly