Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
The game you are in: Misleading through social norms and what’s wrong with it [PDF]
This paper discusses the phenomenon of misleading about “the game you are in.” Individuals who mislead others in this way draw on the fact that we rely on social norms for regulating the levels of alertness, openness, and trust we use in ...
Herzog Lisa
doaj +1 more source
Does one observe chiral symmetry restoration in baryon spectrum? [PDF]
It has recently been suggested that the parity doublet structure seen in the spectrum of highly excited baryons may be due to effective chiral symmetry restoration for these states. We review the recent developments in this field.
Cohen, T. D., Glozman, L. Ya.
core +2 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Reflection of Correct and Incorrect Behaviour in the Russian Paremiological World View
We share the point of view stated and proved by the writer and philosopher Nikolay Kryshchuk: “In any society there are unwritten laws. (...). The oral, traditional arrangement on the main ideas is their cornerstone. It is known, what is good and what is
- Lying Yuan
doaj
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Low-lying dipole strengths for probable $p$-wave one-neutron halos in the medium mass region
The one-neutron halos lying in the island of inversion around $N=20$ has provided the podium, to study the variation of total low-lying dipole strength with the neutron separation energy.
Chatterjee, R. +3 more
core +1 more source
Structural biology of ferritin nanocages
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Efficacy of epidural clonidine versus dexmedetomidine in postoperative analgesia with bupivacaine in total abdominal hysterectomy [PDF]
Introduction: This study compares the efficacy of clonidine and dexmedetomidine as adjuvants to epidural bupivacaine for postoperative analgesia in patients undergoing total abdominal hysterectomy.
C. Nandhini +3 more
doaj

