Results 71 to 80 of about 272,820 (267)
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Journal of Research in Education Sciences本研究旨在運用心率變化偵測學齡前幼兒的焦慮變化，採實驗情境的研究設計，於取得家長同意後，邀請91名5.43-6.49歲幼兒參與有機會說謊的實驗情境，並以運動心率手環記錄幼兒的心率變化。本研究比較幼兒在實驗各期的心率變化，主要目的為：一、探究說謊與誠實組幼兒在實驗過程包含基期、遊戲期、獨處期、回答期共四期的心率變化；二、利用心率手環提供的數據設定警戒值，以區別平靜時（基期）與焦慮時（獨處期、回答期）的狀態。研究發現：一、說謊與誠實組幼兒的心率表現無顯著差異，但幼兒在實驗各期有組內差異 ...
邱淑惠 Shuhui Chiu +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Aporias of Truth and Politics: Arendt, Foucault, and the Practice of Truth-Telling
Genealogy+CritiqueIn the recent debates on so-called 'post-truth politics,' Hannah Arendt's essay "Truth and Politics" is a constant reference point. Indeed, it is one of the few texts within political philosophy and political theory in which the ongoing conflict between ...
Gerald Posselt
doaj +2 more sources
Social Influence, 2018 Nonverbally-expressed emotions are not always linked to people’s true emotions. We investigated whether observers’ ability to distinguish trues from lies differs for positive and negative emotional expressions.
Mariëlle Stel, Eric van Dijk
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Cultural values and human cognition in the Akan proverbs on lying
Studies in African Languages and CulturesThis article investigates the Akan proverbs on the concept of lying aiming at filling the gap in understanding the concept from the perspective of individual languages.
Kofi Agyekum
doaj +1 more source