Results 161 to 170 of about 1,252,989 (357)

MMP2‐Responsive Liposomes Targeting LDLR Enhance the Effectiveness of Anti‐Cancer Drugs in Treating Melanoma

Advanced Therapeutics, EarlyView.
A bi‐functional liposomal system is developed to enhance melanoma therapy, combining mApoE‐mediated targeting of LDLR‐expressing tumor cells with MMP2‐responsive drug release. Loaded with Pimasertib, the liposomes improve intracellular delivery, reduce melanoma viability, and inhibit 3D spheroid growth and invasiveness.
Antonio Renda, Antonia I. Antoniou, Marika Quadri, Susanna Comi, Arianna Amenta, Silvia Sesana, Sara Pellegrino, Pierfausto Seneci, Marcus Koch, Vanna Denti, Giuseppe Paglia, Elisabetta Palazzo, Roberta Lotti, Alessandra Marconi, Francesca Re   +14 more
wiley   +1 more source

Editorial: Advances in Dietary Fat Absorption

Frontiers in Physiology, 2021
Andromeda M. Nauli, Sylvia Santosa, J. Brandon Dixon   +2 more
doaj   +1 more source

RELA Ablation Contributes to Progression of Hepatocellular Carcinoma with TP53R249S Mutation and is a Potential Therapeutic Target

Advanced Science, EarlyView.
Genome‐wide CRISPR/Cas9 based screening identified RELA as a key tumor suppressor in TP53R249S‐mutant HCC. Its loss promotes tumorigenesis and metastasis via DVL1‐mediated Wnt/β‐catenin activation, while its agonist betulinic acid suppresses tumor progression.
Zhiping Wu, Zhe Wang, Diwei Zheng, Yongfang Zheng, Zhiwu Jiang, Jiang Lv, Yueqin Zhu, Heng Jia, Ziyuan Duan, Tingjie Yuan, Qiting Wu, Youguo Long, Shouheng Lin, Yao Yao, Georgia Carson, Jean P. Thiery, Kwan Man, Peng Li   +17 more
wiley   +1 more source

The macroanatomic investigations on the formation of the cisterna chyli and thoracic duct in akkaraman sheep [PDF]

Eurasian Journal of Veterinary Sciences
In this study, formation of Ihe cisterna chyli and course and termination of the thoracic duct were mac-roscopically investigated. In this purpose, eight Akkaraman sheep were used. India ink were injected to various nodes of these animals.
Hakan Yalçın, Sadettin Tıpırdamaz, Kamil Beşoluk   +2 more
doaj  

Comparison of the axillary lymph node between rheumatoid arthritis and psoriatic arthritis with computed tomography

, 2022
Takeshi Fukuda, Reina Kayama, Sho Ogiwara, Takenori Yonenaga, Hiroya Ojiri   +4 more
openalex   +1 more source

The Pathogenic Roles of Local Vitamin D Metabolism Defect in Valve Inflammation and Calcification

Advanced Science, EarlyView.
This study identifies the valvular interstitial cell populations responsible for valvular calcification induced by hyperphosphatemia and likely aging, uncovers local vitamin D metabolism defect‐induced inflammation as a critical pathogenic factor of calcific aortic valve disease, and highlights active vitamin D and ERK inhibitor as potential preventive
Ruichen Yang, Chong Han, Yangli Xie, Shoutao Qiu, Shaoyang Zhang, Jingjia He, Zejian Wang, Zhenlin Zhang, Huijuan Liu, Lin Chen, Baojie Li   +10 more
wiley   +1 more source

COMPARATIVE ANALYSIS OF THE CONTENT IN LYMPH OF HORMONES DRAWING IN PATHOGENESIS OF BREAST CANCER IN RATS WISTAR

Сибирский онкологический журнал, 2016
The aim of the research was to study the levels of hormones involved in the pathogenesis of BC in the lymph of the thoracic duct. Methods. BC induced by the introduction of n-methyl-N-nitrosourea rats of Wistar breed.
A. P. Lykov, M. A. Bondarenko, O. V. Poveshchenko, A. V. Kabakov, T. V. Rayter, O. V. Kazakov, D. N. Strunkin, A. F. Poveshchenko, V. I. Konenkov   +8 more
doaj  

Calhm6 Governs Macrophage Polarization Through Chp1‐Camk4‐Creb1 Axis and Ectosomal Delivery in Inflammatory Responses

Advanced Science, EarlyView.
Calhm6 drives M2 macrophage polarization via the Chp1‐Camk4‐Creb1 axis, suppressing inflammation through calcium‐dependent ectosomal delivery. Calhm6 deficiency enhances M1 responses, boosting bactericidal activity but exacerbating tissue damage. LPS/IFNγ upregulate Calhm6 via Irf1, while IL‐4/Stat6 inhibits it, balancing immune outcomes.
Yanlong Xin, Xiaofan Xiong, Yan Zhang, Siyu Zhang, Shuting Zhang, Yu Yang, Yingxue Liang, Lulu Zang, Xi Chen, Wenjuan Li, Issam Halalmeh, Rui Zhou, Zongfang Li, Haowen Liu, Jing Geng   +14 more
wiley   +1 more source

Caution should be taken in using CD31 for distinguishing the vasculature of lymph nodes [PDF]

, 2003
Hideo Hattori
openalex   +1 more source

Endothelial BMP6 Drives Hemodynamic‐Dependent VSMCs Calcification in Carotid Atherosclerosis

Advanced Science, EarlyView.
The study demonstrates that endothelial cell (EC)‐derived BMP6 promotes the osteogenic differentiation of vascular smooth muscle cells (VSMCs) through cell‐cell interactions. Additionally, the researchers preliminarily explore the driving effect of hemodynamic factors on BMP6‐induced calcification and reveal the regulatory role of KLF4 on BMP6.
Shen Li, Shuang Cao, Peipei Li, Feng Zhang, Gangfeng Ren, Xin Wang, Jiawei Zhao, Chen Liu, Yuan Gao, Jie Xu, Yongjun Wang, Zongping Xia, Yuming Xu   +12 more
wiley   +1 more source