Results 221 to 230 of about 1,201,671 (337)

Reengineering Endogenous Targeting Lipid Nanoparticles (ENDO) for Systemic Delivery of mRNA to Pancreas

open access: yesAdvanced Materials, EarlyView.
ENDO lipid nanoparticles containing cholecalciferol as a fifth component demonstrate mRNA delivery to the pancreas with 99% selectivity, including beta cells. This platform shows minimal toxicity and sustained protein expression for up to 3 days in a dose‐dependent manner, offering a novel approach to pancreas‐specific mRNA delivery and gene therapy ...
Ivan Isaac   +7 more
wiley   +1 more source

Nanostructured Protein Surfaces Inspired by Spider Silk

open access: yesAdvanced Materials, EarlyView.
Harnessing recombinant spider silk technology, bioengineered spidroin variants enable the creation of functionalized nanostructured coatings with tunable affinity for specific targets, supporting a broad range of applications ‐ from antifouling surfaces and targeted drug delivery to advanced cell therapies and precision bio‐patterning via lithography ...
Martin Humenik, Thomas Scheibel
wiley   +1 more source

A Hydro‐Expansive and Degradable Biomaterial Enabling Shape Recovery of Film‐Based Devices in Biofluids

open access: yesAdvanced Materials, EarlyView.
A chitosan‐based bio‐composite exhibits stable and strong tensile strength during volumetric expansion in body fluids, serving as a functional coating that enables a thin film‐based device to self‐flatten from its tubular shape required for catheter delivery.
Ruoxing Wang   +11 more
wiley   +1 more source

Functionalized Antifouling Polymer Brushes for Biospecific Surfaces

open access: yesAdvanced Materials Interfaces, EarlyView.
Modern biosensors offer high sensitivity but often struggle with long‐term stability and selectivity for specific targets. Antifouling polymer brushes help enhance both stability and selectivity. In this review, we compare recent antifouling coatings, their design parameters, and how they are integrated with biorecognition elements for improved ...
Erik J. Postma   +4 more
wiley   +1 more source

Tuning the Morphological Properties of Granular Hydrogels to Control Lymphatic Capillary Formation

open access: yesAdvanced Materials Interfaces, EarlyView.
Tuning the morphological properties of granular hydrogels is essential to generate robust lymphatic capillary networks that express key lymphatic gene and protein markers. The study demonstrates that 3D in vitro lymphatic tube formation is controlled not by the mechanical properties of the gel, but by the pore size and topology (periodicity) of the gel
Daniel Montes   +7 more
wiley   +1 more source

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