Results 171 to 180 of about 783,580 (401)

Assessment of non‐lobe‐specific lymph node metastasis in clinical stage IA non‐small cell lung cancer

open access: yesThoracic Cancer, 2019
Background The rationality of selective mediastinal lymph node dissection based on lobe‐specific metastasis is still controversial. The correlation of lymph node metastasis in lobe‐specific lymphatic drainage regions (LSDRs) and non‐LSDRs has not been ...
Zhirong Zhang   +5 more
doaj   +1 more source

The Tumor‐to‐Endothelial Transfer of FTO Promotes Vascular Remodeling and Metastasis in Nasopharyngeal Carcinoma

open access: yesAdvanced Science, EarlyView.
Integrated omics analysis of matched primary and liver metastatic NPC tumors reveals a unique NOTCH1+ CSC subpopulation exhibiting enhanced stemness properties and tumorigenic capacity. With in vitro and in vivo assays, exosomal transfer of tumor‐derived FTO from NOTCH1+ cells to the endothelium promotes vascular permeability and metastatic potential ...
Chun Wu   +23 more
wiley   +1 more source

Predicting MammaPrint Recurrence Risk from Breast Cancer Pathological Images Using a Weakly Supervised Transformer

open access: yesAdvanced Science, EarlyView.
This study presents CPMP, a weakly supervised transformer model that predicts MammaPrint recurrence risk directly from routine histopathological images of early‐stage HR+/HER2− breast cancer patients. CPMP enables spatial heatmap visualization, analysis of cellular‐level interaction patterns, and an in‐depth characterization of morphological phenotypes
Chaoyang Yan   +8 more
wiley   +1 more source

Biomarkers of lymph node metastasis in colorectal cancer: update

open access: yesFrontiers in Oncology
Colorectal cancer (CRC) ranks as the second leading cause of cancer-related deaths globally, trailing only behind lung cancer, and stands as the third most prevalent malignant tumor, following lung and breast cancers.
Xiao Zhu   +7 more
doaj   +1 more source

Functional radical cervical dissection for differentiated thyroid cancer: the experience of a single center [PDF]

open access: yes, 2018
There is ongoing debate regarding the role of neck dissection in differentiated thyroid cancer, about its usefulness in elective settings, and the increased costs regarding morbidity and operative time.
Adrian, Tulin   +12 more
core   +1 more source

Targeting the SOX9/TIMP1 Axis with iRGD‐Conjugated Nanoplatform Enhances Dendritic Cell Function and Photodynamic Immunotherapy in Gastric Cancer

open access: yesAdvanced Science, EarlyView.
This study identifies the SOX9/TIMP1 axis as a key regulator of immune evasion in gastric cancer. iRGD‐conjugated nanoparticles co‐delivering si‐SOX9, Ce6, and L‐Arg are developed to synergize with photodynamic therapy. The nanoplatform suppresses tumor growth, promotes dendritic cell maturation, and enhances CD8+ T‐cell activation, offering a ...
Banghua Zhong   +3 more
wiley   +1 more source

FXYD3 Promotes Tumor Progression by Binding With IRF7 to Regulate JAK2/STAT5 Signaling in Intrahepatic Cholangiocarcinoma

open access: yesAdvanced Science, EarlyView.
FXYD3 binds IRF7 via its 60–87aa domain, triggering a cGAS/STING‐mediated positive feedback loop amplified by type I interferon. This sustains JAK2/STAT5 activation, accelerating ICC progression. Targeting FXYD3 with siFXYD3@PEP suppresses tumors and enhances chemotherapy sensitivity. Abstract Intrahepatic cholangiocarcinoma (ICC) has a poor prognosis,
Yan Zhou   +13 more
wiley   +1 more source

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