Results 181 to 190 of about 346,670 (346)

The Evolutionary Trajectory and Prognostic Value of GITR+ Tregs Reprogramed by Tumor‐Intrinsic PD‐1/c‐MET Signaling in Pancreatic Cancer

Advanced Science, EarlyView.
In pancreatic ductal adenocarcinoma (PDAC), tumor‐intrinsic PD‐1 signaling activates the MET pathway, leading to the establishment of an immunosuppressive tumor microenvironment (TME). This MET‐driven signaling cascade promotes the selective accumulation of GITR+ regulatory T cells (Tregs), a highly immunosuppressive subset.
Jiande Han, Hanlin Yin, Taochen He, Junyi He, Zhenlai Jiang, Qiangda Chen, Zhihang Xu, Yuqi Xie, Yaolin Xu, Haibo Wang, Wenquan Wang, Wenchuan Wu, Yun Jin, Wenhui Lou, Jun Yu, Ning Pu, Liang Liu   +16 more
wiley   +1 more source

THE POSTOPERATIVE COMBINED THERAPY FOR CARCINOMA OF THE THORACIC ESOPHAGUS COMPLYING WITH THE EXTENT OF LYMPH NODE METASTASIS

, 1985
T Nishihira, Katsu Hirayama, Norio Omori, Michihiko Kitamura, TSUNEO TOYODA, Masayoshi TAN, Saburo Kawachi, J Kuramoto, T Kano, Takashi Akaishi, Satoru Sato, Ryuzaburo Shineha, Kenji Ninomiya, Yoshito Sekine, Masafumi Katayama, Kazunori Sanekata, Kazunori Yoshida, Morio Kasai   +17 more
openalex   +2 more sources

Advanced Microfluidics for Single Cell‐Based Cancer Research

Advanced Science, EarlyView.
Cutting‐edge microfluidic platforms are transforming single‐cell cancer research. This review highlights advanced technologies, from droplet microfluidics to tumour‐chips, that enable functional and spatial single‐cell analyses. By integrating biosensing, immune components, and patient‐derived materials, these systems offer new insights into tumour ...
Adriana Carneiro, Marta Aranda Palomer, Margarida Esteves, Carolina Rodrigues, José Maria Fernandes, Francisca Oliveira, Alexandra Teixeira, Carlos Honrado, Lorena Dieguez, Sara Abalde‐Cela, Miguel Xavier   +10 more
wiley   +1 more source

EVALUATION OF THE METASTASIS RATE OF LYMPH NODES IN GASTRIC CARCINOMA

, 1984
Sumio Kanabe, Yukio OHMORI, Ichiro Honda, Terukazu Muto   +3 more
openalex   +2 more sources

NDRG1‐Driven Lactate Accumulation Promotes Lung Adenocarcinoma Progression Through the Induction of an Immunosuppressive Microenvironment

Advanced Science, EarlyView.
NDRG1 drives lactate accumulation and histone lactylation in lung adenocarcinoma, promoting immunosuppression via M2 macrophage polarization and CD8⁺ T cell inhibition. High NDRG1 expression correlates with poor prognosis, an immunosuppressive microenvironment, and immunotherapy resistance.
Gujie Wu, Hongxia Cheng, Jiacheng Yin, Yuansheng Zheng, Haochun Shi, Binyang Pan, Ming Li, Mengnan Zhao, Jiaqi Liang, Yunyi Bian, Guangyao Shan, Guoshu Bi, Weigang Guo, Lin Wang, Yiwei Huang   +14 more
wiley   +1 more source

RELATIONSHIP BETWEEN NUCLEAR DNA CONTENT AND LYMPH NODE METASTASIS IN RECTAL CANCER

, 1986
Takashi Nishi, Kunio Okajima, Akira Fujiwara, N. Kuromoto, Akihide Kitamura, Hitoshi Mizutani, Tetsuzo Hamahata, T Sogabe, Tadahiro TAGUCHI, Akinori Hara, Akihiko Matsui   +10 more
openalex   +2 more sources

ORL@Cu‐MOF Boost Cuproptosis and Suppress Fatty Acid Metabolism for Cancer Lymph Node Metastasis Synergistic Therapy

Advanced Science, EarlyView.
The fabrication of ORL@Cu‐MOF and the mechanism of synergistic therapy by cuproptosis, reprogram fatty acid metabolism and anti‐PD‐1. Abstract Lymph node metastasis (LNM) is one of the significant characteristics of poor prognosis in oral squamous cell carcinoma (OSCC), strongly associated with high mortality rates.
Zi‐Zhan Li, Yi Liu, Kan Zhou, Lei‐Ming Cao, Guang‐Rui Wang, Jinmei Wu, Yi‐Fu Yu, Yao Xiao, Bing Liu, Qiuji Wu, Zhiyong Song, Lin‐Lin Bu   +11 more
wiley   +1 more source

The collagenase activities, interstitial collagenase and type IV collagenase, in human stomach cancer: with special reference to local spreading and lymph node metastasis.

, 1990
Yoshihide Otani
openalex   +2 more sources

Abnormal β‐Hydroxybutyrylation Modification of ARG1 Drives Reprogramming of Arginine Metabolism to Promote the Progression of Colorectal Cancer

Advanced Science, EarlyView.
Alterations in arginine metabolism and β‐hydroxybutyrylation (Kbhb) modifications play a critical role in tumor progression. This study reveals valuable insights into arginine metabolism reprogramming involving the ARG1‐Kbhb/P300/SLC3A2 signaling axis and uncovers an effective therapy combining BHB with ARG1 inhibitor through conventional enzymatic and
Chuman Lin, Zhiyang Li, Xiaotong Zhu, Wanbing Zhou, Xiansheng Lu, Jiali Zheng, Jie Lin   +6 more
wiley   +1 more source

A Case of Small Cell Lung Cancer with both Sarcoid Reaction and Metastasis in the Regional Lymph Nodes.

, 1994
Masaharu Inagaki, Kiyofumi Mitsui, Eiichi Akaogi, Shigemi Ishikawa, Tatsuo Yamamoto, Takesaburo Ogata   +5 more
openalex   +2 more sources