Results 221 to 230 of about 785,821 (347)

Radiological assessment of dissected cervical lymph nodes in level III affected by the area of supraomohyoid neck dissection. [PDF]

Dentomaxillofac Radiol
Takeshita Y, Ohyama Y, Ibaragi S, Matsushita Y, Tubbs RS, Kitagawa N, Kawazu T, Hisatomi M, Okada S, Fujikura M, Yanagi Y, Iwanaga J.   +11 more
europepmc   +1 more source

Metabolic Reprogramming of T Cells by Dual UCP2 and IL‐17 Blockade Enhances Immunity Against Pancreatic Cancer

Advanced Science, EarlyView.
This study demonstrates that dual UCP2/IL‐17 blockade reprograms T‐cell metabolism to overcome PDAC immunosuppression. Genipin‐mediated UCP2 inhibition enhances CD8⁺ T‐cell IFN‐γ via IL‐12R/STAT4/mTOR signaling and mitochondrial OXPHOS. Combined IL‐17 depletion amplifies Tc1/Th1 responses, reduces MDSCs, and prolongs survival in PDAC models ...
Chuan‐Teng Liu, Chun‐Chieh Yeh, Tsai‐Chen Wu, Chia‐Hsin Lin, Yi‐Ting Kuo, Yoichiro Iwakura, Yuan‐Ji Day, Charles Drake, Vedran Radojcic, Ying‐Chyi Song, Heng‐Hsiung Wu, Hung‐Rong Yen   +11 more
wiley   +1 more source

T cell priming by high avidity neoantigens in lymph nodes augments adoptive immunotherapy. [PDF]

Cancer Immunol Res
Wittling MC, Rivera Reyes AM, Wyatt MM, Cole AC, Smith AS, Rangel Rivera GO, Carmouche JH, Diatikar KG, Ruffin AT, Ware MB, Bennett FJ, Dwyer CJ, Pihl RMF, Kumaresan S, Lesinski GB, Paulos CM, Knochelmann HM.   +16 more
europepmc   +1 more source

Proteogenomic Characterization Reveals Subtype‐Specific Therapeutic Potential for HER2‐Low Breast Cancer

Advanced Science, EarlyView.
Multiomic profiling of HER2‐low breast cancer identifies three proteomic subtypes with distinct therapeutic strategies: endocrine, antiangiogenic, and anti‐HER2 therapies. Genomic and lactate modification landscapes are detailed, providing insights for precise management.
Shouping Xu, Keda Yu, Lei Liu, Qin Wang, Xiaohui Wu, Yihai Chen, Guozheng Li, Xin Zhang, Bo Wei, Zitong Fu, Abiyasi Nanding, Zuxianglan Zhao, Lingbing Yang, Xingda Zhang, Jianyu Wang, Wantong Sun, Yi Hao, Zhongyi Cheng, Xiaojiang Cui, Hao Wu, Da Pang   +20 more
wiley   +1 more source

Role of posterosuperior pancreatic lymph nodes in gallbladder cancer: A study using the efficacy index. [PDF]

Mol Clin Oncol
Yoshino K, Nishizaki S, Tosa H, Yokoyama S, Fuji H, Hata T, Kyogoku T, Itami A.   +7 more
europepmc   +1 more source

Lymph nodes

, 2020
Daniel Bell, Vikas Shah, Joshua Yap
openaire   +1 more source

⁠Engineering Adaptive Immunity in 3D: A Patient‐Specific Lymphoid Model Using Stromal Networks and Peripheral Blood Mononuclear Cells

Advanced Science, EarlyView.
This study presents a 3D lymphoid tissue model engineered from adipose‐derived stem cells differentiated into fibroblastic reticular cell–like networks and co‐cultured with immune cells. The engineered system successfully generates antigen‐specific antibodies and cytokine responses, providing a platform for studying adaptive immunity, vaccine efficacy,
Mei ElGindi, Shaza Karaman, Jeremy Teo
wiley   +1 more source

The microbiological and metabolic traits associated with pT3 colorectal cancer metastasis to lymph nodes. [PDF]

Front Physiol
Chen L, Zhang Y, Wang Y, Cao D, Tai J, Gao K.   +5 more
europepmc   +1 more source

Cancer Stem Cells Shift Metabolite Acetyl‐Coenzyme A to Abrogate the Differentiation of CD103+ T Cells

Advanced Science, EarlyView.
Lei et al. demonstrate that cancer stem cells (CSCs) play a pivotal role in impairing the differentiation of CD103+ T cells in patients with non‐small‐cell lung cancer. The key mechanism involves CSC‐derived acetyl‐CoA, which disrupts CD103+ T cell differentiation by sequentially inducing acetylation and ubiquitination of the Blimp‐1 protein. Targeting
Jiaxin Lei, Huiyan Ji, Jing Guo, Mengdi Liu, Danhua Su, Yiran Zheng, Lin Xu, Qinghua Cao, Tao Ren, Jun Gui, Zhenke Wen   +10 more
wiley   +1 more source

Rare case of skull metastasis from endometrial carcinoma sparing lymph nodes: a case report. [PDF]

J Surg Case Rep
Aldulaijan D, Subaih A, Almuhaimid T, Alnuaimi DA.   +3 more
europepmc   +1 more source