Results 111 to 120 of about 13,250 (289)

A Novel 3D High‐Throughput Phenotypic Drug Screening Pipeline to Identify Drugs with Repurposing Potential for the Treatment of Ovarian Cancer

Advanced Healthcare Materials, Volume 14, Issue 11, April 25, 2025.
Ovarian cancer's high recurrence and therapy resistance demand new strategies. A high‐throughput drug screening pipeline using 3D spheroids, which showed poor concordance with 2D models, identified rapamycin as a promising candidate. In combination with cisplatin, rapamycin demonstrated significant in vitro and in vivo efficacy, highlighting the ...
Nazanin Karimnia, Amy L. Wilson, Brittany R. Doran, Jennie Do, Amelia Matthews, Gwo Y. Ho, Magdalena Plebanski, Thomas W. Jobling, Andrew N. Stephens, Maree Bilandzic   +9 more
wiley   +1 more source

Chronic pelvic pain due to pelvic lymphangioleiomyomatosis: A case report

Gynecology and Minimally Invasive Therapy, 2016
Lymphangioleiomyomatosis (LAM), a rare multisystem disease affecting mainly young women, is characterized by an abnormal proliferation of smooth muscle-like cells in the lungs. We report a case of endometriosis with chronic pelvic pain due to pelvic LAM.
Tetsu Wakimoto, Tateki Tsutsui, Mahiru Kawano, Namhyo Kim, Akihiro Moriyama, Tadashi Kimura   +5 more
doaj   +1 more source

Four-year update of the EXIST-2 study [PDF]

, 2017
Objectives We examined the long-term effects of everolimus in patients with renal angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis.
Belousova, Elena, Bissler, John J., Brakemeier, Susanne, Budde, Klemens, Kingswood, J. Chris, Radzikowska, Elzbieta, Zonnenberg, Bernard A.   +6 more
core   +1 more source

Lymphangioleiomyomatosis: a review of the literature

Respiratory Medicine, 2002
Lymphangioleiomyomatosis (LAM), characterized by alveolar smooth muscle proliferation and cystic destruction of lung parenchyma, can occur as a rare sporadic disease or as a complication of tuberous sclerosis (TSC). It is a cystic lung disease, usually generalized and progressive, may be extremely difficult to treat and has been considered to have a ...
John P. Osborne, E. Hancock
openaire   +3 more sources

A diminutive perivascular epithelioid cell tumor in the colon

DEN Open, Volume 5, Issue 1, April 2025.
Abstract Perivascular epithelioid cell tumor (PEComa) is a rare mesenchymal tumor. Some papers have reported that colonoscopy could be used to treat PEComa with a predominantly pedunculated polyp, whereas surgical intervention is often required for cases with submucosal‐type tumors.
Naoki Sugimura, Daizen Hirata, Mineo Iwatate, Santa Hattori, Mikio Fujita, Wataru Sano, Takahiro Fujimori, Yasushi Sano   +7 more
wiley   +1 more source

Pulmonary lymphangioleiomyomatosis (PLAM)

Lung India, 2007
Pulmonary lymphangioleiomyomatosis (PLAM) is a rare idiopathic, progressive multisystem disorder that predominantly affects women of childbearing age. Here is a report of pulmonary lymphangioleiomyomatosis in 28 years old female who presented with intial
Verma S, Verma Sanjay
doaj  

Official American Thoracic Society/Japanese Respiratory Society Clinical Practice Guidelines: Lymphangioleiomyomatosis Diagnosis and Management.

American Journal of Respiratory and Critical Care Medicine, 2016
BACKGROUND Lymphangioleiomyomatosis (LAM) is a rare cystic lung disease that primarily affects women. The purpose of these guidelines is to provide recommendations for the diagnosis and treatment of LAM.
F. McCormack, N. Gupta, G. Finlay, L. Young, A. Taveira-DaSilva, C. Glasgow, W. Steagall, S. Johnson, S. Sahn, J. Ryu, C. Strange, K. Seyama, E. Sullivan, R. Kotloff, G. Downey, J. Chapman, M. Han, J. D’Armiento, Y. Inoue, E. Henske, J. Bissler, T. Colby, B. Kinder, K. Wikenheiser-Brokamp, K. Brown, J. Cordier, C. Meyer, V. Cottin, J. Brożek, Karen Smith, K. Wilson, J. Moss   +31 more
semanticscholar   +1 more source

Quantifying Spatial Distribution of Ventilation Defects in Multiple Pulmonary Diseases With Hyperpolarized 129Xenon MRI

Journal of Magnetic Resonance Imaging, Volume 61, Issue 4, Page 1860-1873, April 2025.
Background Hyperpolarized 129Xe MRI assesses lung ventilation, often using the ventilation defect percentage (VDP). Unlike VDP, defect distribution index (DDI) quantifies spatial clustering of defects. Purpose To quantify spatial distribution of 129Xe ventilation defects using DDI across pulmonary diseases. Study Type Retrospective.
Abdullah S. Bdaiwi, Matthew M. Willmering, Jason C. Woods, Laura L. Walkup, Zackary I. Cleveland   +4 more
wiley   +1 more source

Efficacy of hormonal suppression in a patient with chyluria due to lymphangioleiomyomatosis

Multidisciplinary Respiratory Medicine, 2011
Lymphangioleiomyomatosis (LAM) is a rare lung disease affecting almost exclusively young women, characterised by abnormal proliferation of atypical smooth muscle cells.
Contini Paola, Schiavina Mario, Schiavina Riccardo, Tavalazzi Francesco, Fabiani Andrea, Di Scioscio Valerio, Spagnolo Paolo, Richeldi Luca   +7 more
doaj   +1 more source

Lymphoid Interstitial Pneumonia Without Known Cause: Diagnostic Work Up and Differential Considerations

Respirology Case Reports, Volume 13, Issue 4, April 2025.
We present a case of diffuse cystic lung disease without any known underlying systemic disorder, biopsy confirmed as lymphoid interstitial pneumonia (LIP). This case highlights the benefit of histological confirmation where there is diagnostic uncertainty and the clinical situation permits, particularly in the setting of symptomatic deterioration ...
Han Xin Lau, Liam Krebs, Sarah Sim, Taryn Reddy   +3 more
wiley   +1 more source