Everolimus safety and efficacy for renal angiomyolipomas associated with tuberous sclerosis complex: A Spanish expanded access trial [PDF]
, 2016 Background: Renal angiomyolipomas (AML) are usual manifestations of tuberous sclerosis complex (TSC) that may cause aneurism-related haemorrhages and renal impairment. Everolimus has emerged as an alternative to surgery/embolization.
Anido, Urbano +13 more
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Estradiol promotes pentose phosphate pathway addiction and cell survival via reactivation of Akt in mTORC1 hyperactive cells [PDF]
, 2014 Lymphangioleiomyomatosis (LAM) is a female-predominant interstitial lung disease that can lead to respiratory failure. LAM cells typically have inactivating TSC2 mutations, leading to mTORC1 activation.
Blenis, J +11 more
core +1 more source
Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells [PDF]
, 2014 Lymphangioleiomyomatosis (LAM) is a progressive neoplastic disorder that leads to lung destruction and respiratory failure primarily in women. LAM is typically caused by tuberous sclerosis complex 2 (TSC2) mutations resulting in mTORC1 activation in ...
Auricchio, Neil +21 more
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Lymphangioleiomyomatosis: diagnosis of a rare cystic lung disease in a clinical case
, 2023 M. A. Makarova, А. V. Chernyak
openalex +2 more sources
COVID-19 in a patient with sporadic lymphangioleiomyomatosis awaiting lung transplantation
, 2021 Yoshimi Noda +10 more
openalex +1 more source
Case report: If it is not asthma—think of lymphangioleiomyomatosis in younger female patients
Frontiers in MedicineLymphangioleiomyomatosis (LAM) is a rare lung disease predominantly affecting women, and it is characterized by the proliferation of smooth muscle cells and cystic lung destruction.
Malene Helligsø Kirkeby +3 more
doaj +1 more source
Recurrent pneumothorax in pregnancy: What should we do after placing an intercostal drain [PDF]
, 2006 Recurrent pneumothorax is rare during pregnancy. We describe a Chinese woman, with a history of spontaneous pneumothorax managed with an intercostal drain, who developed a recurrent pneumothorax during her 32nd week of pregnancy. There is no consensus on
Ho, JC +6 more
core
Identification of driver genes and somatic mutations in cell‐free DNA of patients with pulmonary lymphangioleiomyomatosis [PDF]
, 2019 Li Zhang +8 more
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Activation of the Estrogen Receptor Contributes to the Progression of Pulmonary Lymphangioleiomyomatosis via Matrix Metalloproteinase-Induced Cell Invasiveness [PDF]
, 2008 Marilyn K. Glassberg +7 more
openalex +1 more source