Results 71 to 80 of about 419,246 (294)

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Application of indocyanine green lymphography in the diagnosis and treatment of secondary upper extremity lymphedema: a systematic review

Journal of Plastic Surgery and Hand Surgery
Background: Lymphedema is a chronic progressive disease that impairs patients’ physical and psychological health. This study aimed to conduct a systematic review of the application of indocyanine green (ICG) lymphography for the diagnosis and treatment ...
Youlei Qian, Zixuan Yao, Chao Wang, Chao Dong, Song Xia, Yuguang Sun, Wenbin Shen, Jianfeng Xin   +7 more
doaj   +1 more source

Lymphatic Filariasis Control in Tanzania: Effect of Six Rounds of Mass Drug Administration with Ivermectin and Albendazole on Infection and Transmission. [PDF]

, 2013
Control of lymphatic filariasis (LF) in most countries of sub-Saharan Africa is based on annual mass drug administration (MDA) with a combination of ivermectin and albendazole, in order to interrupt transmission. We present findings from a detailed study
C Chaccour, DJ Tisch, DW Meyrowitsch, DW Meyrowitsch, DW Meyrowitsch, E Michael, E Michael, E Michael, EM Pedersen, Erling M Pedersen, FO Richards, GJ Weil, GJ Weil, GJ Weil, H Joseph, HM Joseph, JD King, JE McMahon, JE McMahon, JL Liang, JM Mlandonicky, KC Kobylinski, KD Ramaiah, KY Won, LM Zeldenryk, M Parker, MN Malecela, Mwele N Malecela, N Kolstrup, O Mitja, Paul E Simonsen, PE Simonsen, PE Simonsen, PE Simonsen, PE Simonsen, PE Simonsen, PE Simonsen, PE Simonsen, PE Simonsen, PE Simonsen, PJ Hotez, RMR Ramzy, RT Rwegoshora, Stephen M Magesa, WHO, WHO, William N Kisinza, YA Derua, Yahya A Derua   +48 more
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

A novel method to allow noninvasive, longitudinal imaging of the murine immune system in vivo [PDF]

, 2012
In vivo imaging has revolutionized understanding of the spatiotemporal complexity that subserves the generation of successful effector and regulatory immune responses.
Andrea J. White, Butcher, Cardillo, Carragher, Catherine M. Rush, Celli, de Boer, Eric J. Jenkinson, Farr, Fulmer, Gianluca Grassia, Girard, Graham Anderson, Gunn, Hillebrands, Huang, Iain B. McInnes, Itano, James M. Brewer, Karen J. Bryson, Kono, Lane, Leishman, Luther, McNagny, Millington, Pasquale Maffia, Paul Garside, Proudman, Robert A. Benson, Schneider, Smith, Stutzmann, Sumen, Tammela, Tomei, Vivienne B. Gibson, White, Worbs, Yoshida, Zinselmeyer   +40 more
core   +2 more sources

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Lymphatic Mapping with Multi-Lymphosome Indocyanine Green Lymphography in Legs with Lymphedema

Archives of Plastic Surgery
It is observed that the locations of the most functional lymphatic vessels in the lymphedematous limbs can differ significantly from those in healthy limbs. The aim of this study was to elucidate the lymphatic map of lymphedematous limbs.
Hisako Hara, Makoto Mihara
doaj   +1 more source

Cerebrovascular Smooth Muscle Cells as the Drivers of Intramural Periarterial Drainage of the Brain

Frontiers in Aging Neuroscience, 2019
The human brain is the organ with the highest metabolic activity but it lacks a traditional lymphatic system responsible for clearing waste products.
Roxana Aldea, Roy O. Weller, Donna M. Wilcock, Roxana O. Carare, Giles Richardson   +4 more
doaj   +1 more source

Intestinal Lymph Flow, and Lipid and Drug Transport Scale Allometrically From Pre-clinical Species to Humans

Frontiers in Physiology, 2020
The intestinal lymphatic system transports fluid, immune cells, dietary lipids, and highly lipophilic drugs from the intestine to the systemic circulation.
Natalie L. Trevaskis, Given Lee, Given Lee, Given Lee, Alistair Escott, Alistair Escott, Kian Liun Phang, Kian Liun Phang, Jiwon Hong, Enyuan Cao, Enyuan Cao, Kasiram Katneni, Susan A. Charman, Sifei Han, Sifei Han, William N. Charman, Anthony R. J. Phillips, Anthony R. J. Phillips, John A. Windsor, John A. Windsor, Christopher J. H. Porter, Christopher J. H. Porter   +21 more
doaj   +1 more source

Key role for inhibins in effective T cell activation, migration and Th17 differentiation

FEBS Open Bio, EarlyView.
Activins/inhibins modulate immune responses. Here, we show that inhibins can be produced very early after T cell activation and can act in an autocrine way, favoring Th1 versus Th17 differentiation and CCL19/CCL21 mediated migration. Recombinant inhibin A can restore the Th1/Th17 balance, highlighting the role of inhibins as key regulators of T cell ...
Sandra Ortega‐Francisco, Roxana Olguín‐Alor, Lizbeth Bolaños‐Castro, Alexandra Morales‐Cruz, Marisol De La Fuente‐Granada, Gloria Soldevila   +5 more
wiley   +1 more source