Results 311 to 320 of about 9,431,933 (366)

FXYD3 Promotes Tumor Progression by Binding With IRF7 to Regulate JAK2/STAT5 Signaling in Intrahepatic Cholangiocarcinoma

Advanced Science, EarlyView.
FXYD3 binds IRF7 via its 60–87aa domain, triggering a cGAS/STING‐mediated positive feedback loop amplified by type I interferon. This sustains JAK2/STAT5 activation, accelerating ICC progression. Targeting FXYD3 with siFXYD3@PEP suppresses tumors and enhances chemotherapy sensitivity. Abstract Intrahepatic cholangiocarcinoma (ICC) has a poor prognosis,
Yan Zhou, Xiaofeng Shen, Shuo Zhang, XiaoHong Pu, Zipeng Xu, Xiang Zhao, Wei Feng, Yuan Liang, Xingtao He, Aihua Yang, Yudong Qiu, Yihang Yuan, Chaobo Chen, Jun Chen   +13 more
wiley   +1 more source

Ang-2 modulates VEGFR3-induced lymphangiogenesis in peritumoral adipose tissue of metastatic head and neck cancer. [PDF]

Cancer Cell Int
Yang LY, Zhang JW, Hu A.
europepmc   +1 more source

Lactate‐Modulating Nanoreactors Facilitate Self‐Amplifying Pyroptosis and the cGAS‐STING Cascade for Potentiated Catalytic‐Immunotherapy

Advanced Science, EarlyView.
An intelligent lactate‐depleting LOCoF2 (CoF2@LOx) nanoreactor system is developed to effectively induce self‐reinforced pyroptosis and activate the cGAS‐STING signaling pathway, thereby inducing a strong immune response and enhancing the therapeutic effectiveness of catalytic immunotherapy.
Linzhu Zhang, Shumin Sun, Duo Wang, Nailin Yang, Di Wang, Jihu Nie, Zifan Pei, Juan Qin, Lei Zhang, Haidong Zhu, Liang Cheng   +10 more
wiley   +1 more source

Percutaneous Thoracic Duct Externalization and Autotransfusion in Patients With Lymphatic Failure Due to Elevated Central Venous Pressure. [PDF]

Circ Cardiovasc Interv
Dori Y, Pinto E, Biroc L, Gillespie MJ, Callahan R, Tang J, O'Byrne ML, Ford B, Vaiyani D, DeWitt AG, Merrill D, Shinde D, Favilla E, Shustak R, Escobar FA, Krishnamurthy G, Srinivasan A, Rome JJ, Smith CL.   +18 more
europepmc   +1 more source

Laeverin is Cell‐Surface Target for Liquid‐Phase Metastasizing Cancer Cells

Advanced Science, EarlyView.
This study revealed that epithelial cancer cells in the floating phase induce the expression of laeverin (LVRN) that is a trophoblast‐specific and cell‐surface immunoregulatory factor and showed that anti‐LVRN ADC is a promising agent that can attack cancer cells in the metastatic liquid phase and block further distant metastasis.
Haruki Kasama, Yuya Sakai, Kyosuke Kagami, Takashi Iizuka, Tatsuhito Kanda, Takuma Suzuki, Kayo Kayahashi, Masanori Ono, Tomoko Fujiwara, Shintaro Yagi, Noriyuki Inaki, Isao Matsumoto, Rena Yamazaki, Kaoru Abiko, Noriomi Matsumura, Akira Hattori, Takiko Daikoku, Hiroshi Fujiwara   +17 more
wiley   +1 more source

Structural Barriers and the Future of AI in Global Health: Lessons From Eradicable Diseases. [PDF]

Cureus
Hailu KT, Haddad RR.
europepmc   +1 more source

Mechanical Stretch‐Induced Interlayer Coordination between MMP2 and COL17A1 Exacerbates Regenerative Exhaustion in Skin

Advanced Science, EarlyView.
Regeneration reaches a hidden limit under mechanical stretch. Prolonged tension alters dermal–epidermal communication, exhausting epidermal stem cells via MMP2–COL17A1 signaling. MMP2 inhibition by Marimastat preserves adhesion and regenerative capacity, offering a potential strategy to overcome the inherent boundaries of skin expansion.
Yidan Sun, Qili Qian, Luwen Xu, Bowen Gao, Ting Li, Yin Li, Jiayi Zheng, Qiaoyu Fu, Xi Cheng, Nuo Chen, Sijia Wang, Liang Zhang, Caiyue Liu, Qingfeng Li   +13 more
wiley   +1 more source

Targeting the glymphatic system: Aβ accumulation and phototherapy strategies across different stages of Alzheimer's disease. [PDF]

Transl Neurodegener
Zhao D, Wang J, Zhu Y, Zhang H, Ni C, Zhao Z, Dai J, He R, Liu G, Gan C, Zhang S, Tong Z.   +11 more
europepmc   +1 more source

A Case of T1bN0 Esophageal Squamous Cell Carcinoma That Developed Recurrence 7 Years after Curative Esophagectomy. [PDF]

Surg Case Rep
Shiomi S, Fukuda T, Nozu S, Oka D, Yoda Y, Motoi N, Kanda H.   +6 more
europepmc   +1 more source

Meningeal lymphatic architecture and drainage dynamics surrounding the human middle meningeal artery. [PDF]

iScience
Albayram M, Richmond SB, Yagmurlu K, Tuna IS, Karakaya E, Ravichandran H, Tufan F, Lesha E, Mut M, Bunyak F, Kalani YS, Ergul A, Seidler RD, Albayram O.   +13 more
europepmc   +1 more source