Results 51 to 60 of about 15,958 (289)

Mutations of AKT3 are associated with a wide spectrum of developmental disorders including extreme megalencephaly [PDF]

, 2017
Mutations of genes within the phosphatidylinositol-3-kinase (PI3K)-AKT-MTOR pathway are well known causes of brain overgrowth (megalencephaly) as well as segmental cortical dysplasia (such as hemimegalencephaly, focal cortical dysplasia and ...
Aaron M Wenger, Adeline Jacquinet, Anand Saggar, Andrew E Timms, Anna Lehman, Arya, Baek, Barkovich, Carpten, Chi Cheng, Chiara Pantaleoni, Cho, Chung, Conti, Crino, Diana Alcantara, Enrico Alfei, Fiona Stewart, Garg, Ghayda M Mirzaa, Gill Bejerano, Harada, Harendra Guturu, Hemming, Hussain, Jamuar, Jansen, John M Graham Jr., Jonathan A Bernstein, Karen Gripp, Kaylee Park, Keppler-Noreuil, Laura Baker, Lee, Lindhurst, László Sztriha, Margot I Van Allen, Mark O’Driscoll, Melinda Zombor, Mirzaa, Mirzaa, Mirzaa, Mirzaa, Mirzaa, Nakamura, Natalia Gomez-Ospina, Negishi, Nellist, Oana Caluseriu, Parikh, Park, Poduri, Renzo Guerrini, Riviere, Robert Hevner, Ronit Mesterman, Sarah Collins, Sarju G Mehta, Slavotinek, Sofia Ygberg, Takagi, Tokuda, Ute Moog, Valerio Conti, Wang, Wieck, William B Dobyns, Wilson, Yang   +68 more
core   +3 more sources

Microphysiological Systems of Lymphatics and Immune Organs

Advanced Healthcare Materials, EarlyView.
This review surveys recent progress in engineering lymphatic microenvironments and immune organoids within microphysiological systems, emphasizing innovative strategies to recreate the biochemical and biophysical complexity of native lymphatic tissues.
Ishita Jain, Ankur Singh, Andrés J. García   +2 more
wiley   +1 more source

Massive fetal chylothorax successfully treated with postnatal talc pleurodesis: A case report and review of the literature

Journal of Pediatric Surgery Case Reports, 2016
Despite the rapid advances in fetal medicine and pediatric surgery, congenital chylothoraces have an associated mortality of 22–65% and an increased morbidity resulting from pulmonary hypoplasia, severe infections secondary to immune globulin ...
Maggie M. Hodges, Timothy M. Crombleholme, Mariana Meyers, Ann Kulungowski, Ahmed I. Marwan, Taizo Nakano, Nicholas Behrendt, Kenneth W. Liechty   +7 more
doaj   +1 more source

Synthetic Cell‐Based Tissues for Bottom‐Up Assembly of Artificial Lymphatic Organs

Advanced Healthcare Materials, EarlyView.
Synthetic cells have emerged as a novel biomimetic approach for fundamental research and therapeutic interventions. T cell activating synthetic cells are able to form 3D tissue‐like structures by self‐assembly into lymphatic bottom‐up tissues (lymphBUT) with tunable biochemical and biomechanical functionalities as well as metabolic activity are ...
Anna Burgstaller, Tamara Nink, Niklas Walter, Erick Angel Lopez Lopez, Hsin‐Fang Chang, Oskar Staufer   +5 more
wiley   +1 more source

A case of distal extrahepatic cholangiocarcinoma with two positive resection margins [PDF]

, 2016
Cholangiocarcinoma is an uncommon primary malignancy of the biliary tract that is challenging to diagnose and treat effectively due to its relatively silent and late clinical presentation.
Andersen, Anderson, Brandi, Brandi, Chung, Dave Harnanan, Ebata, El Rassi, Esposito, Farhat, Geynisman, Han, Hong, Ito, Jarnagin, Khan, Kitagawa, Klöppel, Lazaridis, Murakami, Murakami, Nakeeb, Nuzzo, Parkin, Pitt, Ravi Maharaj, Razumilava, Reddy, Rizvi, Roach, Sasaki, Serafini, Shaib, Soares, Srikanth Umakanthan, Steiner, Wayne A. Warner, Welzel, Wesley Ramcharan, Woo, Yamamoto, Yoshida, Yoshida   +42 more
core   +2 more sources

Remote‐Controllable Immune‐Priming Spot Formation Via Nanocomplexed Hydrogel‐Assisted Histotripsy: Immunoasis

Advanced Materials, EarlyView.
A novel immunotherapeutic strategy combines injectable, adjuvant‐loaded hydrogels with externally controlled histotripsy to create immune‐priming sites within tumors. This approach generates millimeter‐sized immune‐activated lesions with flexible, patient‐tailored treatment scheduling, enabling precise immune activation through tumor ablation‐mediated ...
Sung Hoon Kim, Wonseok Choi, Yurim Kim, Hyeongmin Kim, Gu Won Jeong, Hyewon Park, Inchan Youn, Yoon Park, Sungmin Han, Young‐Min Kim   +9 more
wiley   +1 more source

The paradox of cancer genes in non-malignant conditions: implications for precision medicine. [PDF]

, 2020
Next-generation sequencing has enabled patient selection for targeted drugs, some of which have shown remarkable efficacy in cancers that have the cognate molecular signatures.
Adashek, Jacob J, Kato, Shumei, Kurzrock, Razelle, Lippman, Scott M   +3 more
core  

Infected cystic hygroma resulting in septic shock and respiratory failure: A case report

Journal of Pediatric Surgery Case Reports, 2016
Macrocystic lymphatic malformations (cystic hygromas) are a common cause of cystic neck lesions. These lesions are often diagnosed prenatally in children.
Maria E. Linnaus, David M. Notrica
doaj   +1 more source

Management of severe symptomatic abdominal lymphatic malformation complicated by abscess formation, protein-losing gastroenteropathy, and bleeding [PDF]

, 2022
Hitoshi ONO, Shohei Honda, Hisayuki Miyagi, Masashi Minato, Momoko Ara, Takafumi Kondo, Kazuyoshi Okumura, Tadao Okada, Akinobu Taketomi   +8 more
openalex   +1 more source

Advanced Mounting Technique for Improved Imaging and Analysis of Embedded Spheroids and Migrating Cells in Light Sheet Fluorescence Microscopy

Advanced Materials Technologies, EarlyView.
A novel sample holder compatible with the Zeiss Lightsheet 7 microscope improves imaging of spheroids embedded in collagen matrices. By enabling dual‐sided illumination, it enhances image quality and quantitative analysis of migrating cells. This method advances 3D light sheet microscopy for studying tumor invasion and therapeutic responses.
Masoumeh Mohamadian Namaqi, Franziska Moll, Robert Römer, Andreas Grodrian, Doris Heinrich, Karen Lemke   +5 more
wiley   +1 more source