Results 241 to 250 of about 22,605,370 (372)

5’‐Methylthioadenosine Metabolic Reprogramming Drives H3K79 Monomethylation‐Mediated PAK2 Upregulation to Promote Cadmium‐Induced Breast Cancer Progression by Impairing Autophagic Flux

Advanced Science, EarlyView.
Cadmium, a carcinogenic heavy metal, drives breast cancer progression via metabolic reprogramming and autophagic flux disruption. Multi‐omics revealed cadmium‐induced 5'‐methylthioadenosine depletion activates DOT1L‐mediated H3K79me1 at PAK2 promoter, upregulating PAK2 to block autophagy and driving malignancy. Clinically, 5'‐methylthioadenosine levels
Jingdian Li, Ping Deng, Tengfei Fan, Yuchen Qu, Miduo Tan, Yidan Liang, Peng Gao, Yongchun Peng, Mingke Qin, Sheng Jie, Rongrong Hao, Liting Wang, Lei Zhang, Chunhai Chen, Mindi He, Qinlong Ma, Yan Luo, Li Tian, Jia Xie, Mengyan Chen, Rui Tian, Min Li, Zhengping Yu, Zhou Zhou, Huifeng Pi   +24 more
wiley   +1 more source

Advanced Microfluidics for Single Cell‐Based Cancer Research

Advanced Science, EarlyView.
Cutting‐edge microfluidic platforms are transforming single‐cell cancer research. This review highlights advanced technologies, from droplet microfluidics to tumour‐chips, that enable functional and spatial single‐cell analyses. By integrating biosensing, immune components, and patient‐derived materials, these systems offer new insights into tumour ...
Adriana Carneiro, Marta Aranda Palomer, Margarida Esteves, Carolina Rodrigues, José Maria Fernandes, Francisca Oliveira, Alexandra Teixeira, Carlos Honrado, Lorena Dieguez, Sara Abalde‐Cela, Miguel Xavier   +10 more
wiley   +1 more source

To explore the targeting of toluidine blue: low molecular dextran-40 to the lymphatic system and its effect assessment. [PDF]

Sci Rep
Liu F, Sui Y, Yang M, Wan S, Li W, Shang W, Cui J.   +6 more
europepmc   +1 more source

Nanotechnologies for Physiology-Informed Drug Delivery to the Lymphatic System. [PDF]

Annu Rev Biomed Eng, 2023
Maisel K, McClain CA, Bogseth A, Thomas SN.   +3 more
europepmc   +1 more source

Alymphoplasia (aly)-Type Nuclear Factor κB–Inducing Kinase (Nik) Causes Defects in Secondary Lymphoid Tissue Chemokine Receptor Signaling and Homing of Peritoneal Cells to the Gut-Associated Lymphatic Tissue System

, 2000
Sidonia Fagarasan, Reiko Shinkura, Tadashi Kamata, Fumiaki Nogaki, Koichi Ikuta, Kei Tashiro, Tasuku Honjo   +6 more
openalex   +1 more source

Toward Optimization of Imaging System and Lymphatic Tracer for Near-Infrared Fluorescent Sentinel Lymph Node Mapping in Breast Cancer [PDF]

, 2011
J. Sven D. Mieog, Susan L. Troyan, Merlijn Hutteman, Kevin Donohoe, Joost R. van der Vorst, Alan Stockdale, Gerrit‐Jan Liefers, Hak Soo Choi, Summer L. Gibbs‐Strauss, Hein Putter, Sylvain Gioux, Peter J.K. Kuppen, Yoshitomo Ashitate, Clemens W.G.M. Löwik, Vincent T.H.B.M. Smit, Rafiou Oketokoun, Long Ngo, Cornelis J.�H. van de Velde, John V. Frangioni, Alexander L. Vahrmeijer   +19 more
openalex   +1 more source

The Meningeal Lymphatic System: A New Player in Neurophysiology

Neuron, 2018
Sandro Da Mesquita, Zhongxiao Fu, J. Kipnis   +2 more
semanticscholar   +1 more source

The Pathogenic Roles of Local Vitamin D Metabolism Defect in Valve Inflammation and Calcification

Advanced Science, EarlyView.
This study identifies the valvular interstitial cell populations responsible for valvular calcification induced by hyperphosphatemia and likely aging, uncovers local vitamin D metabolism defect‐induced inflammation as a critical pathogenic factor of calcific aortic valve disease, and highlights active vitamin D and ERK inhibitor as potential preventive
Ruichen Yang, Chong Han, Yangli Xie, Shoutao Qiu, Shaoyang Zhang, Jingjia He, Zejian Wang, Zhenlin Zhang, Huijuan Liu, Lin Chen, Baojie Li   +10 more
wiley   +1 more source

Integrated gross and microanatomical analysis of the periportal lymphatic system in human liver. [PDF]

J Hepatobiliary Pancreat Sci
Mitsuhashi Y, Shimoda H, Umemura K, Kagiya T, Sato K, Narita H, Chiba T, Ishido K, Kimura N, Hakamada K.   +9 more
europepmc   +1 more source

Life Factors and Melanoma: From the Macroscopic State to the Molecular Mechanism

Advanced Science, EarlyView.
Melanoma, an aggressive skin cancer, arises from dynamic interactions between genetic, environmental, and lifestyle factors. This review explores how age, gender, obesity, diet, exercise, smoking, alcohol, UV exposure, circadian rhythms, and medications influence melanoma risk and progression.
Hanbin Wang, Hengxiang Zhang, Yuqi Zhou, Chunying Li, Weinan Guo   +4 more
wiley   +1 more source