Results 271 to 280 of about 830,619 (333)

Assessment of The Lymphatic System of the Genitalia Using Magnetic Resonance Lymphography Before and After Treatment of Male Genital Lymphedema

, 2016
Qing Lü, Zhaohua Jiang, Zizhou Zhao, Lian‐Ming Wu, Guangyu Wu, Shiteng Suo, XU Jian-rong   +6 more
openalex   +1 more source

IR783‐Stabilized Nanodrugs Enhance Anticancer Immune Response by Synergizing Oxidation Therapy and Epigenetic Modulation

Advanced Science, EarlyView.
IR783‐stabilized nanodrugs composed of NIR dye IR783, ROS inducer β‐lapachone, and epigenetic modulator CUDC101 are designed for breast cancer immunotherapy. The nanodrugs can not only promote cancer cell apoptosis through HDAC inhibition‐enhanced oxidation therapy but also reshape the immunosuppressive microenvironment, which provides a novel strategy
Jinzhao Liu, Meicen Wu, Qingyang Lyu, Chang Yang, Ni Fan, Kang Chen, Weiping Wang   +6 more
wiley   +1 more source

A Novel Theranostic Strategy for Malignant Pulmonary Nodules by Targeted CECAM6 with 89Zr/131I‐Labeled Tinurilimab

Advanced Science, EarlyView.
This study investigates the integrated diagnostic and therapeutic strategy utilizing 89Zr/131I‐labeled tinurilimab for the management of malignant lung nodules, with a particular focus on lung adenocarcinoma (LUAD). CEACAM6, which is highly expressed in most LUAD patients, activates the Src/FAK signaling pathway, thereby promoting cell proliferation ...
Chongyang Chen, Keying Zhu, Jing Wang, Donghui Pan, Xinyu Wang, Yuping Xu, Junjie Yan, Lizhen Wang, Min Yang   +8 more
wiley   +1 more source

Simultaneous Reversal of T Lymphocytes and Cancer Cells Metabolism Via a Biomimetic Heavy‐Atom‐Free Photosensitizers‐Based Combination Therapies to Boost Cancer Photoimmunotherapy

Advanced Science, EarlyView.
This work develops a cyanine dye named Cy‐BF and encapsulates it with phospholipids and platelet exosome vesicles to create CHL. Characterized by high phototoxicity, low dark toxicity, and enhanced tumor targeting, CHL demonstrates aggregation‐induced broadening of absorption spectra and NIR‐activated photothermal therapy and type I photodynamic ...
Yongjian Zhang, Xiaohong Wu, Kaiyuan Wang, Yaohan Tang, Xiuxin Lu, Fusheng Sun, Hua Tang, Xiaoyuan Chen, Shipeng Ning   +8 more
wiley   +1 more source

IRF8 Drives Conventional Type 1 Dendritic Cell Differentiation and CD8+ T Cell Activation to Aggravate Abdominal Aortic Aneurysm Development

Advanced Science, EarlyView.
This study highlights the critical role of IRF8 in the development of AAA. IRF8 activation promotes the differentiation of cDC1s, which in turn recruit and activate CD8+ T cells, contributing to aortic wall degradation. The study identifies the IRF8‐cDC1‐CD8+ T cell axis as a key pathway in AAA progression, offering new potential therapeutic targets to
Zhen Yuan, Li Shu, Yidan Zheng, Yidong Wang, Mengsha Zheng, Jie Sun, Jiantao Fu, Zihao Zhou, Shen Song, Zhenjie Liu, Fei Li, Zhejun Cai   +11 more
wiley   +1 more source

Implanted Microneedles Loaded with Sparfloxacin and Zinc‐Manganese Sulfide Nanoparticles Activates Immunity for Postoperative Triple‐Negative Breast Cancer to Prevent Recurrence and Metastasis

Advanced Science, EarlyView.
Hyaluronic acid Microneedles (MNs) are loaded with Sparfloxacin (SP) and zinc‐manganese sulfide (ZMS) for the postoperative in situ treatment of triple‐negative breast cancer (TNBC) to prevent cancer recurrence and combat wound infection. These microneedles enhance antitumor immunity by activating the cGAS‐STING pathway, suppress tumor growth, reduce ...
Zhaoyou Chu, Wang Zheng, Wanyue Fu, Jun Liang, Wanni Wang, Lingling Xu, Xiaohua Jiang, Zhengbao Zha, Haisheng Qian   +8 more
wiley   +1 more source

Cardiomyocyte‐Enriched USP20 Ameliorates Pathological Cardiac Hypertrophy by Targeting STAT3 Deubiquitination

Advanced Science, EarlyView.
Cardiomyocyte‐enriched USP20 regulates the K63‐linked ubiquitination of STAT3, and the cardiomyocyte‐specific USP20‐STAT3‐CARM1 axis exerts a protective role in cardiac hypertrophy. Targeting USP20 through cardiac‐specific gene therapy presents a promising strategy for the treatment of cardiac hypertrophy.
Lingfeng Zhong, Shanshan Dai, Fan Yu, Guo‐Ping Shi, Qinyan Gong, Yucong Zhang, Jingsi Duan, Zhengyin Lou, Zhixuan Tang, Fuzhe Gong, Derong Chen, Liya Hou, Xinyang Hu, Jinghai Chen, Jian'an Wang, Deling Yin   +15 more
wiley   +1 more source

Biological Reinforced Concrete for Cartilage Repair With 3D Printing

Advanced Science, EarlyView.
Inspired by concrete rebar structures in engineering, the concept of biological reinforced concrete uses 3D‐printed ultrafine fiber networks (UFNs) as biodegradable “biorebars”， hybrid biohydrogels as “biocement”， and stem cells as “bioactive aggregates” to fabricate biomimetic cartilage.
Yuewei Chen, Tao Fu, Zhongfei Zou, Yanming Liu, Jianguo Zhu, Binhong Teng, Ke Yao, Haibin Li, Jiachun Li, Zhijian Xie, Yong He   +10 more
wiley   +1 more source

Neophytadiene, a Plant Specialized Metabolite, Mediates the Virus‐Vector‐Plant Tripartite Interactions

Advanced Science, EarlyView.
Tomato chlorosis virus (ToCV) infection induces production of neophytadiene, a volatile resulting from chlorophyll degradation that is highly attractive to whiteflies. OBP2, an odorant‐binding protein from insect vector B. tabaci, exhibits a strong binding affinity for neophytadiene.
Xiao‐bin Shi, Hao Yue, Yan Wei, Evan L. Preisser, Pei Wang, Jiao Du, Ji‐xing Xia, Kai‐long Li, Xin Yang, Jian‐bin Chen, Song‐bai Zhang, Zhan‐hong Zhang, Xu‐guo Zhou, De‐yong Zhang, Yong Liu   +14 more
wiley   +1 more source

Engineered Probiotics Mitigate Gut Barrier Dysfunction Induced by Nanoplastics

Advanced Science, EarlyView.
Intestinal barrier stability is vital for gut health. Plastic polyethylene terephthalate (PET) disrupts this barrier, causing inflammation and infections. This study encodes transforming growth factor‐β into EcN and modifies its surface with pH‐responsive polymer (EcNT@L), creating an oral drug delivery system to repair nano PET‐induced intestinal ...
Wenxin Chen, Qiyan Guo, Hong Li, Xue Chi, Xiang Ma, Yanqiong Tang, Quanfeng Liang, Zhu Liu, Yong Liu, Juanjuan Li   +9 more
wiley   +1 more source