Results 291 to 300 of about 22,436,913 (372)

METTL14‐Mediated M6A Modification of LINC01094 Induces Glucose Metabolic Reprogramming in Breast Cancer by Recruiting the PKM2/JMJD5 Complex

Advanced Science, EarlyView.
METTL14/IGF2BP2‐mediated m6A modification drives LINC01094 upregulation in BC. Then, LINC01094 interacts with PKM2 monomers to promote their dimerization, while serving as a flexible scaffold to facilitate the assembly of the PKM2/JMJD5 complex, synergistically stabilizing PKM2 dimers and enhancing their nuclear translocation.
Mengqi Wang, Zhaoxin Gao, Ruinan Zhao, Pan Zhou, Jingxi Chen, Hui Zhang, Yawen Wang, Wenjie Zhu, Peng Gao   +8 more
wiley   +1 more source

Scholars and scientists in the history of the lymphatic system

Journal of Anatomy, 2017
G. Natale, G. Bocci, D. Ribatti
semanticscholar   +1 more source

USP10 Inhibits Ferroptosis via Deubiquinating POLR2A in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
This study identifies USP10 as a novel deubiquitinase that antagonizes ferroptosis in head and neck squamous cell carcinoma (HNSCC). Mechanistically, USP10 directly stabilizes POLR2A protein through post‐translational deubiquitination, enabling POLR2A‐mediated transcriptional activation of SLC7A11, a key ferroptosis inhibitor.
Diekuo Zhang, Xueying Wang, Shanhong Lu, Yan Gao, Gangcai Zhu, Guo Li, Zongnan Yu, Junwei Hou, Helei Yan, Wenhui Yuan, Xin Zhang, Mien‐Chie Hung, Zhifeng Liu, Yong Liu   +13 more
wiley   +1 more source

Leveraging Lymphatic System Targeting in Systemic Lupus Erythematosus for Improved Clinical Outcomes. [PDF]

Pharmacol Rev
Babalola KT, Arora M, Ganugula R, Agarwal SK, Mohan C, Kumar MNVR.   +5 more
europepmc   +1 more source

Potentiating the Efficacy of mRNA Vaccines through NIR‐II Imaging‐Guided Precise Vaccination

Advanced Science, EarlyView.
A supramolecular strategy is utilized to integrate IR780‐C16 lipids into conventional LNPs, pioneering a novel NIR‐II‐LNPs platform that elucidates the correlations between mRNA vaccines efficacy and vaccination parameters in a non‐invasive approach.
Mengfei Li, Xue Zheng, Xinyang Yu, Shaolong Qi, Shoujun Zhu, Guocan Yu, Songling Zhang   +6 more
wiley   +1 more source

Development of the lymphatic system: new questions and paradigms

Development, 2016
J. Semo, J. Nicenboim, K. Yaniv
semanticscholar   +1 more source

The LDH‐H3K18La‐Nur77 Axis Potentiates Immune Escape in Small Cell Lung Cancer

Advanced Science, EarlyView.
Lactate from SCLC tumors induces H3K18 lactylation in naïve CD8+ T cells, upregulating Nurr77 and enhancing tonic TCR signaling. This leads to T cell hyporesponsiveness to stimulation, impairing antitumor immunity and reducing immunotherapy efficacy.
Xiaoling Shang, Bo Cheng, Chenyue Zhang, Chenglong Zhao, Ruiqing Wang, Xun Zhang, Dizhi Jiang, Xinyu Zhang, Xinyue Ma, Hongyuan Mao, Zerun Li, Chenhan Huang, Tianzi Wang, Kaiyue Guo, Liwen Wang, Ning Tang, Haiyong Wang   +16 more
wiley   +1 more source

Hydraulic control of tuna fins: A role for the lymphatic system in vertebrate locomotion

Science, 2017
Vadim Pavlov, B. Rosental, Nathaniel F. Hansen, Jody M. Beers, George Parish, I. Rowbotham, B. Block   +6 more
semanticscholar   +1 more source

Microbiota-gut-brain axis: interplay between microbiota, barrier function and lymphatic system. [PDF]

Gut Microbes
Zhuang M, Zhang X, Cai J.
europepmc   +1 more source

Delivery Systems for Lymphatic Targeting

, 2013
Indu Singh, Rajan Swami, Wahid Khan, Ramakrishna Sistla   +3 more
openalex   +1 more source