Results 301 to 310 of about 940,554 (332)

Treatment of Lymphedemas by Microsurgical Lymphatic Grafting: What is Proved? [PDF]

, 1990
Baumeister, Rüdiger, Siuda, S.
core  

Enhanced Catalytic Cycle of Glucose Oxidation and Reactive Species with ROS and RHS Generation Mediated by Galvanic Engineering of Dual Atomic Sites on Covalent Organic Frameworks Demonstrating Synergistic Bimetal Tumor Treatment

Advanced Science, EarlyView.
A galvanic replacement is used to control dual atomic metals (Au and Ir) on a covalent organic framework (COF) nanoparticle and then coated with hyaluronic acid (HA). Under a specific bimetallic ratio (COF/Aux/Ir1‐x), the optimization can be achieved for the conversion of intracellular nutrients into reactive species (HOCl and O2• ─) and effectively ...
Wei‐Chung Pan, Cheng‐Hung Luo, Wen‐Ling Lin, Liu‐Chun Wang, Divinah Manoharan, Po‐Ya Chang, Hwo‐Shuenn Sheu, Chen‐Hao Yeh, Chia‐Jui Yen, Chen‐Sheng Yeh   +9 more
wiley   +1 more source

High‐Efficiency Carriers’ Separation Strategy Based Ultrasmall‐Bandgap CuWO4 Sono‐Enhances GSH Antagonism for Cuproptosis Cascade Immunotherapy

Advanced Science, EarlyView.
This study prepares copper tungstate (CuWO4, CWO) nanoparticles for synergistic sono‐enhanced cuproptosis‐based cancer therapy. With an ultrasmall bandgap (1.71 eV), CWO facilitates efficient charge carrier separation under ultrasound, enhancing the generation of reactive oxygen species and the controlled release of Cu2+ ions cascade amplify oxidative ...
Lichao Zhu, Zhisheng Guo, Yu Luo, Haiyan Huang, Kexin Zhang, Bingbing Duan, Renmiao Peng, Haochen Yao, Chao Liang, Kaiyang Wang   +9 more
wiley   +1 more source

QSOX2‐Mediated Disulfide Bond Modification Enhances Tumor Stemness and Chemoresistance by Activating TSC2/mTOR/c‐Myc Feedback Loop in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
High QSOX2 enhances stemness, drug resistance, and metastasis of ESCC cells. QSOX2‐mediated disulfide bond modification activates mTOR/c‐Myc signaling. CAFs‐secreted IGF‐1 drives mTOR/c‐Myc/QSOX2 positive feedback loop. Combining Ebselen, rapamycin, and cisplatin induces tumor dormancy in mice.
Wo‐Ming Chen, Xiao‐Ping Zhang, Xiao Sun, Hai‐Cheng Liu, Yuan‐Yuan Yan, Xue Wei, Yu Liang, Yue Feng, Zhengjie Chen, Yongxu Jia, Chen Jiang, Qian Yan, Lei Li   +12 more
wiley   +1 more source

Bimetallic Ca/Zn Nanoagonist Remould the Immunosuppressive Hepatocellular Carcinoma Microenvironment Following Incomplete Microwave Ablation via Pyroptosis and the STING Signaling Pathway

Advanced Science, EarlyView.
The multifunctional bimetallic Ca/Zn nanoagonist (PZH/Zn@CaNA) significantly downregulated the JAK2‐STAT3 signaling pathway, which effectively inhibited the proliferation and growth of HCC with incomplete microwave ablation. Furthermore, the released bimetallic ions (Ca2⁺ and Zn2⁺) synergistically enhanced oxidative stress‐mediated cytotoxicity ...
Yuan Ling, Xiayi Liang, Kangning Yan, Guichun Zeng, Xiaoqi Zhu, Jinghang Jiang, Shaolong Lu, Xiaobo Wang, Yuying Zhou, Zhaoshen Li, Wei Mai, Duo Wang, Jie Chen   +12 more
wiley   +1 more source

Oxytocin‐Mediate Modulation of Splenic Immunosuppression in Chronic Social Stress Through Neuroendocrine Pathways

Advanced Science, EarlyView.
Chronic social stress elevates oxytocin levels, leading to immunosuppression by enhancing regulatory T‐cell activity and promoting anti‐inflammatory macrophage polarization in the spleen. Blocking oxytocin signaling reverses these effects but worsens stress‐induced behavioral disorders and reduces survival rates. This highlights oxytocin's dual role in
Yi‐Shu Zhang, Hai‐Chao Chen, Jia‐Xin Cao, Si‐Wei Zhou, Yue‐Zhang Ma, Yu‐Hong Jing   +5 more
wiley   +1 more source

A 2D axisymmetric computational model for the study of mass transport into lymphatic capillaries and pre-collector vessels [PDF]

, 2019
Adeli Koudehi, Ghazal, Debbaut, Charlotte, Segers, Patrick, Silvera Delgado, Carlos Alejandro, Van Impe, Matthias   +4 more
core  

The INAVA mRNA in Extracellular Vesicles Activates Normal Ovarian Fibroblasts by Phosphorylation–Ubiquitylation Crosstalk of HMGA2

Advanced Science, EarlyView.
Ovarian cancer‐derived extracellular vesicles (EVs) transfer INAVA mRNA to normal ovarian fibroblasts (NOFs). Translated INAVA protein inhibits HMGA2 phosphorylation‐dependent ubiquitylation and proteasomal degradation, promoting NOF activation.
Lingkai Gu, Zhangjin Shen, Shizhen Shen, Conghui Wang, Yuwan Liu, Xinyi Wei, Mengxia Zheng, Jiaxin Gu, Xiaojing Chen, Yi Sun, Junfen Xu, Yan Lu, Weiguo Lu   +12 more
wiley   +1 more source

The E3 Ubiquitin Ligase ARIH1 Facilitates Colorectal Cancer Progression by Promoting Oxidative Phosphorylation via the Mitochondrial Translocation of K63‐Linked Ubiquitinated PHB1

Advanced Science, EarlyView.
The RBR E3 ubiquitin ligase ARIH1, which is upregulated in colorectal cancer cells, promotes cell growth and metastasis and correlates with an unfavorable CRC prognosis. Mechanistically, ARIH1 catalyzes K63‐linked ubiquitination of PHB1, enhancing the interaction between PHB1 and Akt.
Ying Tong, Zhenling Wang, Yong Wang, Yang Chen, Hongqiang Zhang, Yunfei Lu, Lei Xu, Hengyang Shen, Changzhi Huang, Min Zhao, Wenjie Li, Shuai Wang, Yu Shao, Zan Fu   +13 more
wiley   +1 more source

MAGEA6 Engages a YY1‐Dependent Transcription to Dictate Perineural Invasion in Colorectal Cancer

Advanced Science, EarlyView.
This study investigates the role of MAGEA6 in perineural invasion (PNI) in colorectal cancer (CRC). MAGEA6 promotes CRC invasiveness by inhibiting YY1 ubiquitination, enhancing CXCL1 secretion, and recruiting Schwann cells. These findings highlight the potential of targeting the MAGEA6/YY1/CXCL1 axis for therapeutic strategies against PNI and tumor ...
Hao Wang, Kexin He, Ruixue Huo, Weihan Li, Shan Zhang, Lu‐Ju Jiang, Hao Wu, Minhao Yu, Shu‐Heng Jiang, Junli Xue   +9 more
wiley   +1 more source