Results 71 to 80 of about 923,689 (313)

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Primary Head and Neck Tumour-Derived Fibroblasts Promote Lymphangiogenesis in a Lymphatic Organotypic Co-culture Model

EBioMedicine, 2021
Background: In head and neck cancer, intratumour lymphatic density and tumour lymphangiogenesis have been correlated with lymphatic metastasis, making lymphangiogenesis a promising therapeutic target.
Karina M. Lugo-Cintrón, José M. Ayuso, Mouhita Humayun, Max M. Gong, Sheena C. Kerr, Suzanne M. Ponik, Paul M. Harari, María Virumbrales-Muñoz, David J. Beebe   +8 more
doaj  

Apolipoprotein A‐I Modulates Atherosclerosis Through Lymphatic Vessel‐Dependent Mechanisms in Mice

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2017
Background Subcutaneously injected lipid‐free apoA‐I (apolipoprotein A‐I) reduces accumulation of lipid and immune cells within the aortic root of hypercholesterolemic mice without increasing high‐density lipoprotein–cholesterol concentrations. Lymphatic
Andreea Milasan, Gabriel Jean, F. Dallaire, J. Tardif, Y. Merhi, M. Sorci-Thomas, C. Martel   +6 more
semanticscholar   +1 more source

Chiral Engineered Biomaterials: New Frontiers in Cellular Fate Regulation for Regenerative Medicine

Advanced Functional Materials, EarlyView.
Chiral engineered biomaterials can selectively influence cell behaviors in regenerative medicine. This review covers chiral engineered biomaterials in terms of their fabrication methods, cellular response mechanisms, and applications in directing stem cell differentiation and tissue function.
Yuwen Wang, Xin Zhang, Denghui Xie, Chunying Chen, Zhifeng Huang, Zhong Alan Li   +5 more
wiley   +1 more source

Lymphatic endothelial cells efferent to inflamed joints produce iNOS and inhibit lymphatic vessel contraction and drainage in TNF-induced arthritis in mice

Arthritis Research & Therapy, 2016
BackgroundIn this study, we sought to determine the cellular source of inducible nitric oxide synthase (iNOS) induced in lymphatic endothelial cells (LECs) in response to tumor necrosis factor (TNF), the effects of iNOS on lymphatic smooth muscle cell ...
Q. Liang, Yawen Ju, Yan Chen, Wensheng Wang, Jinlong Li, Li Zhang, Hao Xu, R. Wood, E. Schwarz, B. Boyce, Yongjun Wang, L. Xing   +11 more
semanticscholar   +1 more source

Recent Advances in Highly Luminescent Carbon Dots

Advanced Functional Materials, EarlyView.
Here, a comprehensive summary of the advancements is provided in highly luminescent carbon dots across various luminescence bands since their discovery in 2004. It systematically covers the synthesis, structural characteristics, preparation strategies, and essential purification of these carbon dots, along with their applications in efficient ...
Yupeng Liu, Zhujun Huang, Xuanye Wang, Yiming Hao, Junxiang Yang, Hui Wang, Songnan Qu   +6 more
wiley   +1 more source

Expression of nm23-H1 gene product in esophageal squamous cell carcinoma and its association with vessel invasion and survival

BMC Cancer, 2001
Background We assessed the nm23-H1 gene product expression and its relationship with lymphatic and blood vessel invasion in patients with esophageal squamous cell carcinoma.
Shimizu Tetsuya, Maeda Masayuki, Edagawa Masao, Matsuzaki Yasunori, Ayabe Takanori, Tomita Masaki, Hara Masaki, Onitsuka Toshio   +7 more
doaj   +1 more source

Objective-Dependent Uncertainty Driven Retinal Vessel Segmentation [PDF]

arXiv, 2021
From diagnosing neovascular diseases to detecting white matter lesions, accurate tiny vessel segmentation in fundus images is critical. Promising results for accurate vessel segmentation have been known. However, their effectiveness in segmenting tiny vessels is still limited.
arxiv  

Binding of Hyaluronan to the Native Lymphatic Vessel Endothelial Receptor LYVE-1 Is Critically Dependent on Receptor Clustering and Hyaluronan Organization*

Journal of Biological Chemistry, 2016
The lymphatic endothelial receptor LYVE-1 has been implicated in both uptake of hyaluronan (HA) from tissue matrix and in facilitating transit of leukocytes and tumor cells through lymphatic vessels based largely on in vitro studies with recombinant ...
William I. Lawrance, Suneale Banerji, A. Day, Shaumick Bhattacharjee, D. Jackson   +4 more
semanticscholar   +1 more source

“Therapies Through Gut:” Targeted Drug Delivery for Non‐Gastrointestinal Diseases by Oral Administration

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray, Shehzahdi S. Moonshi, Hang Thu Ta   +2 more
wiley   +1 more source