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Acute lymphoblastic leukemia [PDF]

open access: yesPediatric Blood & Cancer, 2021
AbstractThe survival of patients with acute lymphoblastic leukemia (ALL) has improved significantly with the use of intensive multimodality treatment regimens including chemotherapy, high‐dose chemotherapy and stem cell rescue, and radiation therapy when indicated.
John Han‐Chih Chang   +4 more
openaire   +3 more sources

T-Lymphoblastic Leukemia/Lymphoma [PDF]

open access: yesAmerican Journal of Clinical Pathology, 2015
To review important concepts from the 2013 Society for Hematopathology/European Association for Haematopathology Workshop session on T-acute lymphoblastic leukemia/T-lymphoblastic lymphoma (T-ALL/T-LBL).Twenty-one submitted cases are reviewed and summarized, with emphasis on key diagnostic or biologic points, and supplemented with relevant literature ...
L. Jeffrey Medeiros   +2 more
openaire   +3 more sources

Quaternion-Valued Convolutional Neural Network Applied for Acute Lymphoblastic Leukemia Diagnosis [PDF]

open access: yesA. Britto and K. Valdivia Delgado (Eds.): BRACIS 2021, LNAI 13074, pp. 280-293, 2021. Springer Nature Switzerland AG 2021, 2021
The field of neural networks has seen significant advances in recent years with the development of deep and convolutional neural networks. Although many of the current works address real-valued models, recent studies reveal that neural networks with hypercomplex-valued parameters can better capture, generalize, and represent the complexity of ...
arxiv   +1 more source

Acute Lymphoblastic Leukemia Detection Using Hypercomplex-Valued Convolutional Neural Networks [PDF]

open access: yes2022 International Joint Conference on Neural Networks (IJCNN), 2022
This paper features convolutional neural networks defined on hypercomplex algebras applied to classify lymphocytes in blood smear digital microscopic images. Such classification is helpful for the diagnosis of acute lymphoblast leukemia (ALL), a type of blood cancer.
arxiv   +1 more source

Antileukemic Efficacy of Continuous vs Discontinuous Dexamethasone in Murine Models of Acute Lymphoblastic Leukemia. [PDF]

open access: yesPLoS ONE, 2015
Osteonecrosis is one of the most common, serious, toxicities resulting from the treatment of acute lymphoblastic leukemia. In recent years, pediatric acute lymphoblastic leukemia clinical trials have used discontinuous rather than continuous dosing of ...
Laura B Ramsey   +12 more
doaj   +1 more source

CD123 expression patterns and selective targeting with a CD123-targeted antibody-drug conjugate (IMGN632) in acute lymphoblastic leukemia

open access: yesHaematologica, 2019
The potential of CD123-targeted therapies in acute lymphoblastic leukemia/lymphoma remains largely unexplored. We examined CD123 expression levels in a large cohort of patients with acute lymphoblastic leukemia/lymphoma and assessed the in vitro impact ...
Evgeniya Angelova   +14 more
doaj   +1 more source

Rationale for an international consortium to study inherited genetic susceptibility to childhood acute lymphoblastic leukemia

open access: yesHaematologica, 2011
Acute lymphoblastic leukemia is the major pediatric cancer in developed countries. To date most association studies of acute lymphoblastic leukemia have been based on the candidate gene approach and have evaluated a restricted number of polymorphisms ...
Amy L. Sherborne   +35 more
doaj   +1 more source

Oral health management in children with acute lymphoblastic leukemia

open access: yes口腔疾病防治, 2021
Acute lymphoblastic leukemia is the most common type of leukemia in children. In recent years, the treatment and prognosis of acute lymphoblastic leukemia in children have improved significantly. However, acute lymphoblastic leukemia itself and treatment
TANG Yawen   +4 more
doaj   +1 more source

MicroRNA-128-3p is a novel oncomiR targeting PHF6 in T-cell acute lymphoblastic leukemia

open access: yesHaematologica, 2014
T-cell acute lymphoblastic leukemia arises from the leukemic transformation of developing thymocytes and results from cooperative genetic lesions. Inactivation of the PHF6 gene is frequently observed in T-cell acute lymphoblastic leukemia, suggesting an ...
Evelien Mets   +15 more
doaj   +1 more source

Therapy-related acute lymphoblastic leukemia has distinct clinical and cytogenetic features compared to de novo acute lymphoblastic leukemia, but outcomes are comparable in transplanted patients

open access: yesHaematologica, 2018
Therapy-related acute lymphoblastic leukemia remains poorly defined due to a lack of large data sets recognizing the defining characteristics of this entity.
Ibrahim Aldoss   +20 more
doaj   +1 more source

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