Results 91 to 100 of about 577,742 (361)

CD30 as a Target Molecule in the Diagnosis and Therapy of Lymphomas

American Journal of Hematology, EarlyView.
ABSTRACT The tumor necrosis factor (TNF)‐receptor superfamily 8 receptor CD30 molecule is expressed in all tumor cells of Hodgkin lymphoma and anaplastic large cell lymphoma but is only weakly expressed in a small subset of large lymphoid cells in normal peripheral lymphoid tissues.
Harald Stein, Brunangelo Falini
wiley   +1 more source

Efficacy of Tyrosine Kinase Inhibitors in Ph-like Acute Lymphoblastic Leukemia harboring ABL-class Rearrangements.

Blood, 2019
Tanasi et al present a prospective strategy for identifying patients with Philadelphia-like acute lymphoblastic leukemia, demonstrating the efficacy of early introduction of tyrosine kinase inhibitors in improving outcomes.
I. Tanasi, I. Ba, N. Sirvent, T. Braun, W. Cuccuini, P. Ballerini, Nicolas Duployez, A. Tanguy‐Schmidt, J. Tamburini, S. Maury, E. Doré, C. Himberlin, C. Duclos, P. Chevallier, P. Rousselot, M. Bonifacio, H. Cavé, A. Baruchel, H. Dombret, J. Soulier, J. Landman-Parker, N. Boissel, E. Clappier   +22 more
semanticscholar   +1 more source

Artificial intelligence modelling of tyrosine kinase inhibitors at risk of malabsorption and bioavailability‐enhancing strategies

British Journal of Clinical Pharmacology, EarlyView.
Aims The study aims to predict and improve the absorption of tyrosine kinase inhibitors (TKIs) in patients with malabsorption issues, particularly those who have undergone bariatric surgery or are using proton‐pump inhibitors. The research involves 2 main components: the development of an artificial intelligence (AI) model to identify TKIs that are ...
Daan W. Huntjens, Olivier J. M. Béquignon, Stefanie D. Krens, Mark Löwenberg, Martine E. D. Chamuleau, Remco J. Molenaar, Anita M. G. Kramers, Marianne A. Kuijvenhoven, Imke H. Bartelink   +8 more
wiley   +1 more source

Pharmacogenomics in clinical practice: Biomarker information in Brazilian drug labels

British Journal of Clinical Pharmacology, EarlyView.
This review examines the PGx annotations in package inserts (bulas in Brazilian Portuguese) approved by ANVISA, the Brazilian Health Regulatory Agency, for 19 gene–drug pairs with strong or moderate recommendations for initial dosing alteration in the CPIC (Clinical Pharmacogenetic Implementation Consortion) guidelines and PGx testing required or ...
Guilherme Suarez‐Kurtz
wiley   +1 more source

MiR-7 Functions as a Tumor Suppressor by Targeting the Oncogenes TAL1 in T-Cell Acute Lymphoblastic Leukemia

Technology in Cancer Research & Treatment, 2020
Background: T-cell acute lymphoblastic leukemia is a hematologic malignancy characterized by T-cell proliferation, and in many cases, the ectopic expression of the oncogenic transcription factor T-cell acute lymphocytic leukemia protein 1 (TAL1 ...
Hongbo Sun MD, Zhifu Zhang MD, Wei Luo MD, Junmin Liu MD, Ye Lou MD, Shengmei Xia MD   +5 more
doaj   +1 more source

The genomic landscape of pediatric acute lymphoblastic leukemia

Nature Genetics, 2022
Samuel W. Brady, K. Roberts, Zhaohui Gu, Lei Shi, S. Pounds, Deqing Pei, Cheng Cheng, Yunfeng Dai, M. Devidas, Chunxu Qu, Ashley N Hill, D. Payne-Turner, Xiaotu Ma, I. Iacobucci, Pradyuamna Baviskar, Lei Wei, Sasi Arunachalam, Kohei Hagiwara, Yanling Liu, Diane A. Flasch, Yu Liu, Matthew Parker, Xiaolong Chen, A. Elsayed, Omkar Pathak, Yongjin Li, Yiping Fan, J. R. Michael, Michael C. Rusch, M. Wilkinson, Scott G. Foy, D. Hedges, S. Newman, Xin Zhou, Jian Wang, Colleen Reilly, Edgar Sioson, Stephen V. Rice, Victor B Pastor Loyola, Gang Wu, E. Rampersaud, S. Reshmi, J. Gastier-Foster, Jaime M Guidry Auvil, Patee Gesuwan, Malcolm A. Smith, N. Winick, A. Carroll, N. Heerema, R. Harvey, C. Willman, E. Larsen, E. Raetz, M. Borowitz, B. Wood, W. Carroll, P. Zweidler-McKay, K. Rabin, L. Mattano, K. Maloney, S. Winter, M. Burke, W. Salzer, K. Dunsmore, A. Angiolillo, K. Crews, J. Downing, S. Jeha, C. Pui, W. Evans, Jun J. Yang, M. Relling, D. Gerhard, M. Loh, S. Hunger, Jinghui Zhang, C. Mullighan   +76 more
semanticscholar   +1 more source

Lactylation in cancer biology: Unlocking new avenues for research and therapy

Cancer Communications, EarlyView.
Abstract Lactylation, a newly identified post‐translational modification, plays a multifaceted role in cancer biology by integrating epigenetic and non‐epigenetic mechanisms. This review summarizes the latest research progress on lactylation, including its functions in epigenetic regulation and its broader impact on cellular processes.
Xiaoyu Hou, Zhenya Hong, Huimin Zeng, Changyi Zhang, Peng Zhang, Ding Ma, Zhiqiang Han   +6 more
wiley   +1 more source

Acute lymphoblastic leukemia in adolescents and young adults in Finland

Haematologica, 2008
Background Interest has recently been paid to adolescents and young adults with acute lymphoblastic leukemia, particularly because all reports so far published indicate that these patients have a better outcome when treated with pediatric rather than ...
Anu Usvasalo, Riikka Räty, Sakari Knuutila, Kim Vettenranta, Arja Harila-Saari, Esa Jantunen, Marjut Kauppila, Pirjo Koistinen, Katriina Parto, Pekka Riikonen, Toivo T. Salmi, Raija Silvennoinen, Erkki Elonen, Ulla M. Saarinen-Pihkala   +13 more
doaj   +1 more source

Unraveling Novel Genetic Determinants of Thiopurine Response Via TWAS

Clinical Pharmacology &Therapeutics, EarlyView.
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Thiopurines such as 6‐mercaptopurine (6MP) are essential in ALL maintenance therapy. However, dose‐limiting toxicities can significantly disrupt treatment. While genetic variants in TPMT and NUDT15 are known to affect thiopurine response, many patients with normal function ...
Carlotta Bidoli, Wenjian Yang, Seth E. Karol, Marianna Lucafò, Gabriele Stocco, Jun J. Yang   +5 more
wiley   +1 more source

Treatment of acute lymphoblastic leukemia in adolescents and a-dults: A retrospective study of 41 patients (1970-1973) [PDF]

, 1975
Roel Willemze, H.F.P. Hillen, Hartgrink-Groeneveld Ca, C. Haanen   +3 more
openalex   +3 more sources