Results 101 to 110 of about 139,045 (309)
Advanced Intelligent Systems, EarlyView.Here, we present RanBALL, an ensemble random projection‐based model for accurate and cost‐effective identification of B‐cell acute lymphoblastic leukemia subtypes is presented. By preserving patient‐to‐patient distance after dimension reduction by random projection and ensemble learning, RanBALL can facilitate the discovery of B‐ALL subtype‐specific ...
Lusheng Li +6 more
wiley +1 more source
A Population‐Based Assessment of Cancer Risk in Children With VACTERL
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Cancer risk in children with VACTERL, a nonrandom co‐occurrence of ≥ 3 defects (vertebral, anal, cardiac, tracheoesophogeal fistula, renal, and limb), remains unclear. We evaluated this association in a population‐based study. We analyzed data from the Genetic Overlap Between Anomalies and Cancer in Kids (GOBACK) Study, a US registry linkage ...
Ji Yun Tark +15 more
wiley +1 more source
No benefit of Interfant protocols compared to BFM‐based protocols for infants with acute lymphoblastic leukemia. Results from an institution in Argentina [PDF]
, 2020 Carla Pennella +10 more
openalex +1 more source
Reviewer #2 (Public Review): RAG1 and RAG2 non-core regions are implicated in the leukemogenesis and off-target V(D)J recombination in BCR-ABL1-driven B cell lineage lymphoblastic leukemia [PDF]
, 2023 Amit Verma +9 more
openalex +1 more source
British Journal of Clinical Pharmacology, EarlyView.While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis +5 more
wiley +1 more source
Predictors of etiology and drug resistance in children with new‐onset focal seizures
Epilepsia Open, EarlyView.Abstract Objective To examine the clinical features of new‐onset focal seizures in children and investigate clinical associations and predictors of underlying etiology and drug resistance. Methods Data were gathered from The Children's Hospital at Westmead admissions for patients aged 1 month to 18 years who presented with new‐onset focal seizures ...
Byoung Chan Lee +7 more
wiley +1 more source
The hidden regulators: Non‐coding RNAs in KMT2A‐rearranged acute lymphoblastic leukemia
International Journal of Cancer, EarlyView.Abstract Acute lymphoblastic leukemia (ALL) driven by KMT2A rearrangements (KMT2A‐r) is an aggressive hematologic malignancy with poor prognosis and a high incidence in infants. While KMT2A fusion proteins drive leukemogenesis through transcriptional dysregulation, recent discoveries have highlighted the pivotal role of non‐coding RNAs (ncRNAs) in ...
Maria Augusta Poersch +5 more
wiley +1 more source
International Journal of Cancer, EarlyView.What's New? Hypoxic regions and inflammatory Th17 cells in the tumor environment are both associated with poor prognosis in cervical cancer. However, synergistic mechanisms between hypoxia and Th17 cells remain elusive. This study demonstrated Th17–hypoxia‐driven mechanisms underlying cervical cancer progression.
Selina Gies +12 more
wiley +1 more source