Results 11 to 20 of about 555,062 (342)

Pediatric acute lymphoblastic leukemia

Haematologica, 2020
The last decade has witnessed great advances in our understanding of the genetic and biological basis of childhood acute lymphoblastic leukemia (ALL), the development of experimental models to probe mechanisms and evaluate new therapies, and the ...
H. Inaba, C. Mullighan
semanticscholar   +6 more sources

T-Lymphoblastic Leukemia/Lymphoma [PDF]

American Journal of Clinical Pathology, 2015
To review important concepts from the 2013 Society for Hematopathology/European Association for Haematopathology Workshop session on T-acute lymphoblastic leukemia/T-lymphoblastic lymphoma (T-ALL/T-LBL).Twenty-one submitted cases are reviewed and summarized, with emphasis on key diagnostic or biologic points, and supplemented with relevant literature ...
L. Jeffrey Medeiros, M. James You, Eric D. Hsi   +2 more
openaire   +3 more sources

Adult Acute Lymphoblastic Leukemia [PDF]

Mayo Clinic Proceedings, 2005
Much progress has been made in understanding the biology of and therapy for acute lymphoblastic leukemia (ALL). This progress has translated into the recognition of several subgroups of ALL and the institution of risk-adapted therapies. New therapies are emerging based on the definition of specific cytogenetic-molecular abnormalities.
Stefan Faderl, Elias Jabbour, Hagop M. Kantarjian   +2 more
openaire   +4 more sources

MicroRNA-128-3p is a novel oncomiR targeting PHF6 in T-cell acute lymphoblastic leukemia

Haematologica, 2014
T-cell acute lymphoblastic leukemia arises from the leukemic transformation of developing thymocytes and results from cooperative genetic lesions. Inactivation of the PHF6 gene is frequently observed in T-cell acute lymphoblastic leukemia, suggesting an ...
Evelien Mets, Gert Van Peer, Joni Van der Meulen, Michael Boice, Tom Taghon, Steven Goossens, Pieter Mestdagh, Yves Benoit, Barbara De Moerloose, Nadine Van Roy, Bruce Poppe, Jo Vandesompele, Hans-Guido Wendel, Pieter Van Vlierberghe, Frank Speleman, Pieter Rondou   +15 more
doaj   +1 more source

Relapsed Acute Lymphoblastic Leukemia

Indian Journal of Pediatrics, 2023
AbstractOutcomes for children with acute lymphoblastic leukemia (ALL) have improved worldwide to >85%. For those who relapse, outcomes have remained static at ~50% making relapsed acute lymphoblastic leukemia one of the leading causes of death in childhood cancers.
Sidhu, Jasmeet, Gogoi, Manash Pratim, Krishnan, Shekhar, Saha, Vaskar   +3 more
openaire   +3 more sources

Therapy-related acute lymphoblastic leukemia has distinct clinical and cytogenetic features compared to de novo acute lymphoblastic leukemia, but outcomes are comparable in transplanted patients

Haematologica, 2018
Therapy-related acute lymphoblastic leukemia remains poorly defined due to a lack of large data sets recognizing the defining characteristics of this entity.
Ibrahim Aldoss, Tracey Stiller, Ni-Chun Tsai, Joo Y. Song, Thai Cao, N. Achini Bandara, Amandeep Salhotra, Samer Khaled, Ahmed Aribi, Monzr M. Al Malki, Matthew Mei, Haris Ali, Ricardo Spielberger, Margaret O’Donnell, David Snyder, Thomas Slavin, Ryotaro Nakamura, Anthony S. Stein, Stephen J. Forman, Guido Marcucci, Vinod Pullarkat   +20 more
doaj   +1 more source

In vitro validation of γ-secretase inhibitors alone or in combination with other anti-cancer drugs for the treatment of T-cell acute lymphoblastic leukemia

Haematologica, 2008
Background Activating NOTCH1 mutations are common in T-cell acute lymphoblastic leukemia. Inhibition of NOTCH1 signaling with γ-secretase inhibitors causes cell cycle block, but only after treatment for several days.
Kim De Keersmaecker, Idoya Lahortiga, Nicole Mentens, Cedric Folens, Leander Van Neste, Sofie Bekaert, Peter Vandenberghe, Maria D. Odero, Peter Marynen, Jan Cools   +9 more
doaj   +1 more source

Association of ARID5B gene variants with acute lymphoblastic leukemia in Yemeni children

Tumor Biology, 2017
Studies have shown an association between ARID5B gene polymorphisms and childhood acute lymphoblastic leukemia. However, the association between ARID5B variants and acute lymphoblastic leukemia among the Arab population still needs to be studied. The aim
Boshra Al-absi, Suzita M Noor, Riyadh Saif-Ali, Sameer D Salem, Radwan H Ahmed, Muhammad FM Razif, Sekaran Muniandy   +6 more
doaj   +1 more source

The role of ZAP70 kinase in acute lymphoblastic leukemia infiltration into the central nervous system

Haematologica, 2017
Central nervous system infiltration and relapse are poorly understood in childhood acute lymphoblastic leukemia. We examined the role of zeta-chain-associated protein kinase 70 in preclinical models of central nervous system leukemia and performed ...
Ameera Alsadeq, Henning Fedders, Christian Vokuhl, Nele M. Belau, Martin Zimmermann, Tim Wirbelauer, Steffi Spielberg, Michaela Vossen-Gajcy, Gunnar Cario, Martin Schrappe, Denis M. Schewe   +10 more
doaj   +1 more source

Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia with e1a3 BCR-ABL1 transcript in a Nigerian with sickle cell anemia: a case report

Journal of Medical Case Reports, 2021
Background The occurrence of acute leukemia in patients with sickle cell anemia is uncommon. The Philadelphia chromosome is the hallmark of chronic myeloid leukemia.
Ibrahim O. Ahmed, Lauretta O. Ochogwu, Temilola O. Owojuyigbe, Norah O. Akinola, Muheez A. Durosinmi   +4 more
doaj   +1 more source