Results 201 to 210 of about 230,151 (306)

CRISPR‐Cas9 screen reveals that inhibition of enhancer of zeste homolog 2 sensitizes malignant T cells to dimethyl‐fumarate‐induced cell death

The FEBS Journal, EarlyView.
A genome‐wide CRISPR‐Cas9 screen identified H3K27 methylation as a key regulator of T‐cell lymphoma sensitivity to dimethyl fumarate (DMF). Specifically, inhibition of enhancer of zeste homolog 2 (EZH2) enhanced DMF‐induced cell death in malignant T cells. These results provide functional evidence for the role of EZH2 in modulating drug sensitivity and
Jan P. Teubner, Deniz Tümen, Arne Kandulski, Philipp Heumann, Patricia Mester, Elisabeth Aschenbrenner, Kirstin Pollinger, Manuela Gunckel, Barbara Volz, Tobias Hein, Paul L. Beltzig, Luisa Tengler, Florian Voll, Marina Kreutz, Claudia Kunst, Jan P. Nicolay, Martina Müller, Karsten Gülow   +17 more
wiley   +1 more source

Adipocytes Impair Mitoxantrone Cytotoxicity Against Acute Lymphoblastic Leukemia. [PDF]

EJHaem
Cohen M, Orgel E, Nevarez-Mejia J, Chen T, Neely M, Louie S, Mittelman SD.   +6 more
europepmc   +1 more source

Dimerization‐dependent NOTCH receptor transactivation unveils a class of highly selective NOTCH signalling inhibitors

The FEBS Journal, EarlyView.
NOTCH signalling is indispensable for tissue homeostasis and, consequently, corruption of its normal function promotes numerous diseases, including cancer. However, the development of targeted therapies has been hampered by inefficacy and overt toxicity. Here, we show that NOTCH receptor dimerization is necessary for receptor transactivation, which has
Xinxin Liu, Haijiang Wang, Gunja Mishra, Lin‐Ting Wu, Chao Li, Maarten van Dinther, Jin Liu, Manuel A.F.V. Gonçalves, Peter ten Dijke, David A. Baker   +9 more
wiley   +1 more source

Insights into the Prognostic Value of Telomere Length in Childhood Acute Lymphoblastic Leukemia. [PDF]

Life (Basel)
Vakonaki E, Pelagiadis I, Baliou S, Tzatzarakis MN, Alegakis A, Lygerou I, Fragkiadaki P, Stratigaki M, Katzilakis N, Tsatsakis A, Stiakaki E.   +10 more
europepmc   +1 more source

Diffuse cranial nerve infiltration in acute lymphoblastic leukemia: MRI diagnosis. [PDF]

Radiol Case Rep
Ali M, Zineb M, Ayoub C, Jalal EK, Oula A, El Mahdi C, Asmae OA, Siham AR.   +7 more
europepmc   +1 more source

Acute Lymphoblastic Leukemia Associated with a t(l;l9)(q23;pl3) in an Adult.

, 1993
Hitoshi Ohno, Tetsurou INOUE, Takashi Akasaka, Atsuko Okumura, Setsuko Miyanishi, Isao OHASHI, Masahiko Kikuchi, Masahiro Masuya, Hiroyuki Amano, Takanobu Imanaka, Yoh-ichirou Ohno   +10 more
openalex   +2 more sources

The PNH French Working Group Experience: Building a Strong Network of Cytometrists

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction The PNH working group was created in 2010 to initiate a workshop on testing white blood cells to share international recommendations. Methods Thirty‐five French and Belgian laboratories equipped with 2‐ or 3‐laser cytometers applied three different panels with or without FLAER reagent in 305 samples.
Orianne Wagner‐Ballon, Magali Le Garff‐Tavernier, Rémi Lestestu, Bernard Drenou, Agathe Debliquis, the PNH French Working Group «CytHem‐HPN», Chantal Fossat, Claire Loosen, Bernard Chatelain, Marie Loosveld   +9 more
wiley   +1 more source

Azanucleoside treatment leads to B-cell precursor acute lymphoblastic leukemia. [PDF]

Blood Neoplasia
Negi V, Bertoli R, Tuckey O, Zhu YJ, Walker RL, Difilippantonio MJ, Doroshow JH, Meltzer PS, Aplan PD.   +8 more
europepmc   +1 more source

A der(1;15)(q10;q10) is a rare nonrandom whole-arm translocation in patients with acute lymphoblastic leukemia

, 2007
Tae Sung Park, Jaewoo Song, Kyung‐A Lee, Sang‐Guk Lee, Seoyoung Yoon, Jin Seok Kim, Chuhl Joo Lyu, Jong Rak Choi   +7 more
openalex   +2 more sources

Allogeneic haematopoietic cell transplant in cutaneous T‐cell lymphomas: Recommendations from the EBMT PH&G Committee

Journal of the European Academy of Dermatology and Venereology, EarlyView.
This EBMT Practice Harmonisation and Guidelines Committee consensus provides practical recommendations for the selection, timing and conduct of allogeneic transplantation in advanced‐stage mycosis fungoides and Sézary syndrome, aiming to optimize outcomes through early multidisciplinary collaboration and evidence‐based decision‐making.
Gandhi Damaj, Adèle de Masson, Peter Dreger, Ali Bazarbachi, Philipp Berning, Rafael F. Duarte, Christopher P. Fox, Emmanuella Guenova, Olivier Hermine, Charalampia Kyriakou, Alina Tanase, Olivier Tournilhac, Wojiech Jurczak, Imke E. Karsten, Stéphanie Nguyen Quoc, Yasmina Serroukh, Federico Stella, Gerald Wulf, Anna Sureda, Evangelia Papadavid, Pablo L. Ortiz‐Romero, Annalisa Ruggeri, Isabel Sánchez‐Ortega, Julia J. Scarisbrick, Ibrahim Yakoub‐Agha, Francesco Onida, Norbert Schmitz   +26 more
wiley   +1 more source