Results 261 to 270 of about 555,062 (342)

CRISPR‐Cas9 screen reveals that inhibition of enhancer of zeste homolog 2 sensitizes malignant T cells to dimethyl‐fumarate‐induced cell death

The FEBS Journal, EarlyView.
A genome‐wide CRISPR‐Cas9 screen identified H3K27 methylation as a key regulator of T‐cell lymphoma sensitivity to dimethyl fumarate (DMF). Specifically, inhibition of enhancer of zeste homolog 2 (EZH2) enhanced DMF‐induced cell death in malignant T cells. These results provide functional evidence for the role of EZH2 in modulating drug sensitivity and
Jan P. Teubner, Deniz Tümen, Arne Kandulski, Philipp Heumann, Patricia Mester, Elisabeth Aschenbrenner, Kirstin Pollinger, Manuela Gunckel, Barbara Volz, Tobias Hein, Paul L. Beltzig, Luisa Tengler, Florian Voll, Marina Kreutz, Claudia Kunst, Jan P. Nicolay, Martina Müller, Karsten Gülow   +17 more
wiley   +1 more source

The real world of acute lymphoblastic leukemia. [PDF]

Haematologica
Litzow MR.
europepmc   +1 more source

Cyclophosphamide—A promising solution for refractory ICANS

British Journal of Haematology, EarlyView.
Manan Vora, Himanshu Gujarathi, Hasmukh Jain, Alok Shetty, Vasundhara Patil, Savan Pandey, M. V. Ramya Kumar, Lingaraj Nayak   +7 more
wiley   +1 more source

Acute Pancreatitis Associated With Blinatumomab Treatment in a Patient With Acute Lymphoblastic Leukemia. [PDF]

Cureus
Kazi AY, Zaidi Z, Zahid M.
europepmc   +1 more source

The PNH French Working Group Experience: Building a Strong Network of Cytometrists

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction The PNH working group was created in 2010 to initiate a workshop on testing white blood cells to share international recommendations. Methods Thirty‐five French and Belgian laboratories equipped with 2‐ or 3‐laser cytometers applied three different panels with or without FLAER reagent in 305 samples.
Orianne Wagner‐Ballon, Magali Le Garff‐Tavernier, Rémi Lestestu, Bernard Drenou, Agathe Debliquis, the PNH French Working Group «CytHem‐HPN», Chantal Fossat, Claire Loosen, Bernard Chatelain, Marie Loosveld   +9 more
wiley   +1 more source

Rituximab efficacy for minimal residual disease eradication in philadelphia-negative acute lymphoblastic leukemia CD20. [PDF]

Ann Hematol
Cecchi N, Sciumè M, Ricchiuti A, Bosi A, Tagliaferri E, Passamonti F, Fracchiolla NS.   +6 more
europepmc   +1 more source

Hypothermia in Acute Lymphoblastic Leukemia

Annals of Saudi Medicine, 1994
Fahad Z. Fiar, Hugh M. Clink, Bent Stigsby   +2 more
openaire   +3 more sources

The Application of Artificial Intelligence‐Based Bone Marrow Cell Analysis System in Pediatric Hematological Diseases

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction The clinical diagnosis of hematological diseases depends on the differential count of nucleated cells on the bone marrow (BM) smears, and an artificial intelligence (AI)‐based system was applied to automatically classify BM nucleated cells in pediatric hematological disease samples in this study.
Xin He, Fei He, Yan Wang, Yu Liu, Xiaopeng Gao, Mingrui Yu, Haiyan Gao   +6 more
wiley   +1 more source

Metabolic reprogramming promotes apoptosis resistance in acute lymphoblastic leukemia through CASP3 lactylation. [PDF]

Mol Cancer
Lin Z, Long F, Liu J, Kang R, Klionsky DJ, Kroemer G, Tang D, Yang M.   +7 more
europepmc   +1 more source

Sketching T cell atlases in the single‐cell era: challenges and recommendations

Immunology &Cell Biology, EarlyView.
Recent advances in single‐cell technologies have enabled the creation of T cell atlases, providing detailed maps of adaptive immunity across tissues, development and disease states. These atlases help uncover T cell diversity, functional states and disease mechanisms, aiding in the identification of therapeutic targets.
Itana Bojović, António GG Sousa, Sini Junttila, Laura L Elo   +3 more
wiley   +1 more source