Results 271 to 280 of about 555,062 (342)

Advances in Therapy of Adult Patients with Acute Lymphoblastic Leukemia. [PDF]

Cells
Sucre O, Pamulapati S, Muzammil Z, Bitran J.   +3 more
europepmc   +1 more source

Use of a Foamy‐Virus Vector System to Produce an ‘Off‐the‐Shelf’ Fcγ‐CR‐T Cell Product for the Treatment of Haematological and Solid Tumour Malignancies

Immunology, EarlyView.
Despite the huge success of chimeric antigen receptor (CAR)‐T cells in the treatment of hematologic malignancies, safety concerns have recently been raised in terms of tumorigenesis, relating to the viral vector systems used for product generation, underlying the need for alternative methods for gene modification.
Ioanna Lazana, Emmanouil Simantirakis, Evangelos Kourous, Maria Daniil, Dimitris Ioannou, George Vassilopoulos   +5 more
wiley   +1 more source

GDF11 downregulates FOXP3 in T-cell acute lymphoblastic leukemia-derived cells and associates with restraining aggressiveness. [PDF]

Oncol Res
SáNCHEZ-RODRíGUEZ M, Lazzarini-Lechuga R, Souza-Arroyo V, Bucio-Ortiz L, Miranda-Labra RU, Gerardo-RAMíREZ M, PáEZ-Arenas A, Vergara-Mendoza M, CONCEPCIóN GUTIéRREZ-Ruiz M, Escobedo-Calvario A, Gomez-Quiroz LE.   +10 more
europepmc   +1 more source

Precision oncology to overcome resistance in R/R AML in children and adults requires combinations of cytotoxic, targeted, and immunological treatments

Journal of Internal Medicine, EarlyView.
Abstract Although outcomes for newly diagnosed acute myeloid leukaemia (AML) have been incrementally improved over the last decades, management of relapsed and refractory (R/R) AML remains a medical challenge. A curative intent for R/R AML usually involves chemotherapy (with or without targeted therapy) with subsequent consolidation, including ...
Martin Jädersten, Ingrid Lilienthal, Christer Nilsson, Louisa Fredrikson, Cornelis Jan Pronk, Kristian Løvvik Juul‐Dam, Mika Kontro, Nikolas Herold   +7 more
wiley   +1 more source

Erratum: JUN mediates glucocorticoid resistance by stabilizing HIF1a in T cell acute lymphoblastic leukemia. [PDF]

iScience
Zhang Z, Shi J, Wu Q, Zhang Z, Liu X, Ren A, Zhao G, Dong G, Wu H, Zhao J, Zhao Y, Hu J, Li H, Zhang T, Zhou F, Zhu H.   +15 more
europepmc   +1 more source

Mosaic variants of neurodevelopmental and mitochondrial genes in postmortem paraventricular thalamus in bipolar disorder detected by deep exome sequencing

Psychiatry and Clinical Neurosciences, EarlyView.
Aim The genetic architecture of bipolar disorder (BD) remains incompletely understood despite extensive genomic studies. Postzygotic mosaic variants have emerged as promising contributors to BD; however, the landscape of such variants in the BD brain has yet to be elucidated.
Masaki Nishioka, Zen‐ichi Tanei, Yuko Saito, Maho Morishima, Mizuki Hino, Kanako Mori, Atsuko Nagaoka, Risa Shishido, Rie Saito, Hideaki Kitamura, Akito Nagakura, Araki Kimura, Shuji Iritani, Kenichi Oshima, Akiyoshi Kakita, Yasuto Kunii, Shigeo Murayama, Tadafumi Kato   +17 more
wiley   +1 more source

Circulating tumor-associated and neoantigen-specific endogenous T cells in children treated for B-acute lymphoblastic leukemia. [PDF]

Hemasphere
Huwiler E, Thierry AC, Michaux J, Pak H, Huber F, Arber C, Bassani-Sternberg M, Harari A, Ceppi F.   +8 more
europepmc   +1 more source

The Landscape of Cancer Metabolism as a Therapeutic Target

Pathology International, EarlyView.
ABSTRACT Cancer cells reprogram their metabolism during progression to adapt to the tumor microenvironment, which is characterized by distinct differences in nutrient availability, oxygen concentrations, and acidity. This metabolic reprogramming can simultaneously create metabolic vulnerabilities unique to cancer cells, making cancer metabolism a ...
Kenji Ohshima
wiley   +1 more source

DNA-incorporated thioguanine to detect potential non-adherence to maintenance therapy in acute lymphoblastic leukemia. [PDF]

Cancer Chemother Pharmacol
Koch MR, Buhl Rasmussen AS, Als-Nielsen B, Duarte X, Escherich G, Heyman M, Lepik K, Malmros J, Nersting J, Johannsdottir I, Niinimäki R, Petersen MJ, Segers H, van der Sluis IM, Thastrup M, Vaitkeviciene G, Schmiegelow K, Toksvang LN.   +17 more
europepmc   +1 more source

Effect of Antibiotics With Anaerobic Coverage on Graft‐Versus‐Host Disease in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta‐Analysis

Transplant Infectious Disease, EarlyView.
ABSTRACT Background Broad‐spectrum antibiotics are standard for febrile neutropenia (FN) in allogeneic hematopoietic stem cell transplantation (HSCT) but may disrupt gut microbiota, increasing the risk of graft‐versus‐host disease (GVHD). However, current evidence on the effects of anaerobic versus limited anaerobic antibiotic coverage on GVHD‐related
Hiroshi Ito, Yui Okamura, Yuna Tomura, Jura Oshida, Minori Fujita, Daiki Kobayashi   +5 more
wiley   +1 more source