Results 311 to 320 of about 577,742 (361)
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Granular Acute Lymphoblastic Leukemia
American Journal of Clinical Pathology, 1983Granules in blasts are most typical of acute myeloblastic leukemia. However, there have been scattered reports of patients with acute lymphoblastic leukemia (ALL) that have lymphoblasts with azurophilic cytoplasmic granules. These reports do not describe immunologic markers or cytogenetics.
Debra Butler +5 more
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Pediatric Clinics of North America, 1980
The improved outlook in childhood leukemia can be attributed to more accurate diagnosis, better supportive care, the use of drug combinations to achieve and maintain remission, and prophylactic therapy to prevent central nervous system leukemia. With the best treatment available today, 65 to 70 per cent of children are in complete continuous remission ...
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The improved outlook in childhood leukemia can be attributed to more accurate diagnosis, better supportive care, the use of drug combinations to achieve and maintain remission, and prophylactic therapy to prevent central nervous system leukemia. With the best treatment available today, 65 to 70 per cent of children are in complete continuous remission ...
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Pathobiology of acute lymphoblastic leukemia
Seminars in Diagnostic Pathology, 2011In the present review, the authors described the pathobiological features of B- and T-ALL, which appear to be quite heterogeneous with regard to molecular pathogenesis. The last edition of the World Health Organization Classification considered this aspect by defining many entities based on genetic findings.
PAOLINI, STEFANIA +5 more
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B-Lymphoblastic Lymphoma/Leukemia
2013T-lymphoblastic lymphoma/leukemia (T-LBL) is a neoplasm of immature lymphoid cells (lymphoblasts) committed to the T-cell lineage. The disease usually presents as an extramedullary tumor mass in the anterior mediastinum or lymph nodes (T-LBL). A smaller subset of patients present with predominant blood and bone marrow involvement (T-lymphoblastic ...
Roberto N. Miranda +2 more
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Hematology/Oncology Clinics of North America, 2009
Acute lymphoblastic leukemia and lymphoblastic lymphoma constitute a family of genetically heterogeneous lymphoid neoplasms derived from B- and T-lymphoid progenitors. Diagnosis is based on morphologic, immunophenotypic, and genetic features that allow differentiation from normal progenitors and other hematopoietic and nonhematopoietic neoplasms ...
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Acute lymphoblastic leukemia and lymphoblastic lymphoma constitute a family of genetically heterogeneous lymphoid neoplasms derived from B- and T-lymphoid progenitors. Diagnosis is based on morphologic, immunophenotypic, and genetic features that allow differentiation from normal progenitors and other hematopoietic and nonhematopoietic neoplasms ...
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Treatment of Acute Lymphoblastic Leukemia
Annual Review of Medicine, 1972The treatment of acute lymphoblastic leukemia in the last decade can be said to have reached a revolutionary phase. Prior to that time, the disease was considered to be uniformly fatal and treatment was being given essen tially for palliation. These concepts have changed and now the well-informed investigator is employing acute leukemia protocols ...
Joseph H. Burchenal +2 more
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Childhood acute lymphoblastic leukemia
Reviews in Clinical and Experimental Hematology, 2002As cure rates in childhood acute lymphoblastic leukemia reach 80%, emphasis is increasingly placed on the accurate identification of drug‐resistant cases, the elucidation of the mechanisms involved in drug resistance and the development of new therapeutic strategies targeted toward the pivotal molecular lesions.
Mary V. Relling +3 more
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Childhood Acute Lymphoblastic Leukemia
Pediatric Annals, 1988Acute lymphoblastic leukemia accounts for 80% of leukemia in children. The exact cause is unknown, but some genetic, immunologic, viral, and environmental factors have been implicated. Symptoms at the time of diagnosis frequently include fever, bleeding, fatigue, and irritability. Initial white blood cell count and patient age at diagnosis are the most
Carol Diamond, Katherine K Matthay
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Acute lymphoblastic leukemia in the elderly
European Journal of Haematology, 1990We report our findings in 18 patients with acute lymphoblastic leukemia (ALL) aged 60 years or older. A preleukemic syndrome was observed in 2 patients. Compared to younger adults with ALL, L3 morphology was unexpectedly frequent (4/16) T‐ALL was not observed. Other criteria of poor prognosis (high white blood cell count, CNS involvement, organomegaly,
Delannoy, André +7 more
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Recent advances in the treatment of acute lymphoblastic leukemia
Leukemia and Lymphoma, 2019Acute lymphoblastic leukemia (ALL) is a heterogeneous disease with a bimodal distribution. The progresses made in understanding its biology led to the development of targeted therapies.
H. Rafei, H. Kantarjian, E. Jabbour
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