Results 31 to 40 of about 577,742 (361)

P190BCR-ABL1 in a Patient with Philadelphia Chromosome Positive T-Cell Acute Lymphoblastic Leukemia: A Rare Case Report and Review of Literature

Case Reports in Oncology, 2021
T-acute lymphoblastic leukemia/lymphoblastic lymphoma (T-ALL/LBL) is rare and aggressive leukemia. Philadelphia chromosome positive (Ph+) is the most common cytogenetic abnormality in chronic myeloid leukemia (CML) and B-acute lymphoblastic leukemia (B ...
Samah Kohla, Sarah EL Kourashy, Zafar Nawaz, Reda Youssef, Ahmad Al-Sabbagh, Feryal A. Ibrahim   +5 more
doaj   +1 more source

Clinical and Biological Correlates of Neurotoxicity Associated with CAR T-cell Therapy in Patients with B-cell Acute Lymphoblastic Leukemia.

Cancer Discovery, 2018
CD19-specific chimeric antigen receptor (CAR) T-cell therapy is highly effective against relapsed or refractory acute lymphoblastic leukemia (ALL), but is hindered by neurotoxicity.
B. Santomasso, Jae H. Park, Darin Salloum, I. Rivière, J. Flynn, E. Mead, E. Halton, Xiuyan Wang, B. Senechal, Terence J. Purdon, J. Cross, Hui Liu, B. Vachha, Xi Chen, L. Deangelis, Daniel H. Li, Y. Bernal, M. Gonen, H. Wendel, M. Sadelain, R. Brentjens   +20 more
semanticscholar   +1 more source

Prognostic relevance of RUNX1 mutations in T-cell acute lymphoblastic leukemia

Haematologica, 2011
The runt-related transcription factor 1, RUNX1, is crucial in the development of myeloid and lymphoid cell lineages and has been reported to be mutated in myeloid malignancies in approximately 30% of cases.
Vera Grossmann, Wolfgang Kern, Stefan Harbich, Tamara Alpermann, Sabine Jeromin, Susanne Schnittger, Claudia Haferlach, Torsten Haferlach, Alexander Kohlmann   +8 more
doaj   +1 more source

Immature MEF2C-dysregulated T-cell leukemia patients have an early T-cell precursor acute lymphoblastic leukemia gene signature and typically have non-rearranged T-cell receptors

Haematologica, 2014
Three distinct immature T-cell acute lymphoblastic leukemia entities have been described including cases that express an early T-cell precursor immunophenotype or expression profile, immature MEF2C-dysregulated T-cell acute lymphoblastic leukemia cluster
Linda Zuurbier, Alejandro Gutierrez, Charles G. Mullighan, Kirsten Canté-Barrett, A. Olivier Gevaert, Johan de Rooi, Yunlei Li, Willem K. Smits, Jessica G.C.A.M. Buijs-Gladdines, Edwin Sonneveld, A. Thomas Look, Martin Horstmann, Rob Pieters, Jules P.P. Meijerink   +13 more
doaj   +1 more source

Three-dimensional chromatin landscapes in T cell acute lymphoblastic leukemia

Nature Genetics, 2020
Differences in three-dimensional (3D) chromatin architecture can influence the integrity of topologically associating domains (TADs) and rewire specific enhancer–promoter interactions, impacting gene expression and leading to human disease.
A. Kloetgen, Palaniraja Thandapani, P. Ntziachristos, Yohana Ghebrechristos, Sofia Nomikou, C. Lazaris, Xufeng Chen, Hai-yang Hu, Sofia Bakogianni, Jingjing Wang, Yi Fu, F. Boccalatte, Hua Zhong, E. Paietta, Thomas Trimarchi, Yixing Zhu, P. Van Vlierberghe, G. Inghirami, T. Lionnet, I. Aifantis, A. Tsirigos   +20 more
semanticscholar   +1 more source

Prognosis of children with mixed phenotype acute leukemia treated on the basis of consistent immunophenotypic criteria

Haematologica, 2010
Background Mixed phenotype acute leukemia (MPAL) represents a diagnostic and therapeutic dilemma. The European Group for the Immunological Classification of Leukemias (EGIL) scoring system unambiguously defines MPAL expressing aberrant lineage markers ...
Ester Mejstrikova, Jana Volejnikova, Eva Fronkova, Katerina Zdrahalova, Tomas Kalina, Jaroslav Sterba, Yahia Jabali, Vladimir Mihal, Bohumir Blazek, Zdena Cerna, Daniela Prochazkova, Jiri Hak, Zuzana Zemanova, Marie Jarosova, Alexandra Oltova, Petr Sedlacek, Jiri Schwarz, Jan Zuna, Jan Trka, Jan Stary, Ondrej Hrusak   +20 more
doaj   +1 more source

Poor Prognosis Biomolecular Factors Are Highly Frequent in Childhood Acute Leukemias From Oaxaca, Mexico

Technology in Cancer Research & Treatment, 2020
Objective: To investigate the cellular and molecular epidemiology of acute leukemias in vulnerable populations of children and adolescents in Oaxaca de Juarez, Mexico.
Gerardo Juárez-Avendaño MSc, Nuria Citlalli Luna-Silva MD, Euler Chargoy-Vivaldo MD, Laura Alicia Juárez-Martínez MD, Mayra Noemí Martínez-Rangel BS, Noemí Zárate-Ortiz BS, Edith Martínez-Valencia BS, Briceida López-Martínez MD, Rosana Pelayo PhD, Juan Carlos Balandrán PhD   +9 more
doaj   +1 more source

B-Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma [PDF]

American Journal of Clinical Pathology, 2015
This session of the 2013 Society of Hematopathology/European Association for Haematopathology Workshop was dedicated to B-acute lymphoblastic leukemia (B-ALL)/lymphoblastic lymphoma (LBL) with recurrent translocations and not otherwise specified.In this review, we summarize the cases discussed during the workshop, review the pertinent and most recent ...
Jeffrey L. Jorgensen, Sanam Loghavi, Jeffery L. Kutok   +2 more
openaire   +3 more sources

Acute lymphoblastic leukemia: a comprehensive review and 2017 update

Blood Cancer Journal, 2017
Acute lymphoblastic leukemia (ALL) is the second most common acute leukemia in adults, with an incidence of over 6500 cases per year in the United States alone.
T. Terwilliger, M. Abdul-Hay
semanticscholar   +1 more source

Asparagine Synthetase in Cancer: Beyond Acute Lymphoblastic Leukemia

Frontiers in Oncology, 2020
Asparagine Synthetase (ASNS) catalyzes the synthesis of the non-essential amino acid asparagine (Asn) from aspartate (Asp) and glutamine (Gln). ASNS expression is highly regulated at the transcriptional level, being induced by both the Amino Acid ...
Martina Chiu, G. Taurino, M. Bianchi, M. Kilberg, O. Bussolati   +4 more
semanticscholar   +1 more source