Results 41 to 50 of about 555,062 (342)

Correlation of Serum Lipoproteins with the Activity of Acute Lymphoblastic Leukaemia

مجله كليه طب الكندي, 2019
Background: the activity of acute lymphoblastic leukemia had been observed to correlate with levels of serum lipoproteins Objective: to evaluate the correlation of serum levels of different types of lipoproteins with activity of the disease in ...
Azher Sebieh Al-Zubaidy
doaj   +1 more source

Poor Prognosis Biomolecular Factors Are Highly Frequent in Childhood Acute Leukemias From Oaxaca, Mexico

Technology in Cancer Research & Treatment, 2020
Objective: To investigate the cellular and molecular epidemiology of acute leukemias in vulnerable populations of children and adolescents in Oaxaca de Juarez, Mexico.
Gerardo Juárez-Avendaño MSc, Nuria Citlalli Luna-Silva MD, Euler Chargoy-Vivaldo MD, Laura Alicia Juárez-Martínez MD, Mayra Noemí Martínez-Rangel BS, Noemí Zárate-Ortiz BS, Edith Martínez-Valencia BS, Briceida López-Martínez MD, Rosana Pelayo PhD, Juan Carlos Balandrán PhD   +9 more
doaj   +1 more source

Blinatumomab for minimal residual disease in adults with B-cell precursor acute lymphoblastic leukemia.

Blood, 2018
Approximately 30% to 50% of adults with acute lymphoblastic leukemia (ALL) in hematologic complete remission after multiagent therapy exhibit minimal residual disease (MRD) by reverse transcriptase-polymerase chain reaction or flow cytometry.
N. Gökbuget, H. Dombret, M. Bonifacio, A. Reichle, C. Graux, C. Faul, H. Diedrich, M. Topp, M. Brüggemann, H. Horst, V. Havelange, J. Stieglmaier, Hendrik Wessels, V. Haddad, J. Benjamin, G. Zugmaier, D. Nagorsen, R. Bargou   +17 more
semanticscholar   +1 more source

Replication analysis confirms the association of ARID5B with childhood B-cell acute lymphoblastic leukemia

Haematologica, 2010
Although childhood acute lymphoblastic leukemia is the most common pediatric cancer, its etiology remains poorly understood. In an attempt to replicate the findings of 2 recent genome-wide association studies in a French-Canadian cohort, we confirmed the
Jasmine Healy, Chantal Richer, Mathieu Bourgey, Ekaterini A. Kritikou, Daniel Sinnett   +4 more
doaj   +1 more source

Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T-cell Therapy for Acute Lymphoblastic Leukemia.

Cancer Discovery, 2016
UNLABELLED Chimeric antigen receptor (CAR)-modified T cells with anti-CD19 specificity are a highly effective novel immune therapy for relapsed/refractory acute lymphoblastic leukemia.
D. Teachey, D. Teachey, S. Lacey, P. Shaw, J. Melenhorst, S. Maude, N. Frey, E. Pequignot, V. Gonzalez, Fang Chen, J. Finklestein, D. Barrett, S. Weiss, J. Fitzgerald, R. Berg, R. Aplenc, C. Callahan, S. Rheingold, Zhaohui Zheng, S. Rose-John, J. White, Farzana Nazimuddin, G. Wertheim, B. Levine, C. June, D. Porter, S. Grupp   +26 more
semanticscholar   +1 more source

THE GENOMIC LANDSCAPE OF PEDIATRIC AND YOUNG ADULT T-LINEAGE ACUTE LYMPHOBLASTIC LEUKEMIA

Nature Genetics, 2017
Genetic alterations that activate NOTCH1 signaling and T cell transcription factors, coupled with inactivation of the INK4/ARF tumor suppressors, are hallmarks of T-lineage acute lymphoblastic leukemia (T-ALL), but detailed genome-wide sequencing of ...
Yu Liu, J. Easton, Ying Shao, J. Maciaszek, Zhaoming Wang, M. Wilkinson, K. McCastlain, Michael N. Edmonson, S. Pounds, Lei Shi, Xin Zhou, Xiaotu Ma, Edgar Sioson, Yongjin Li, Michael C. Rusch, P. Gupta, Deqing Pei, Cheng Cheng, Malcolm A. Smith, J. G. Auvil, D. Gerhard, M. Relling, N. Winick, A. Carroll, N. Heerema, E. Raetz, M. Devidas, C. Willman, R. Harvey, W. Carroll, K. Dunsmore, S. Winter, B. Wood, B. Sorrentino, J. Downing, M. Loh, S. Hunger, Jinghui Zhang, C. Mullighan   +38 more
semanticscholar   +1 more source

Blinatumomab in pediatric patients with relapsed/refractory B‐cell precursor acute lymphoblastic leukemia

European Journal of Haematology, 2020
Pediatric patients with relapsed or refractory acute lymphoblastic leukemia have a poor prognosis. We here assess the response rates, adverse events, and long‐term follow‐up of pediatric patients with relapsed/refractory acute lymphoblastic leukemia ...
M. Queudeville, P. Schlegel, Amadeus T Heinz, T. Lenz, M. Döring, U. Holzer, U. Hartmann, H. Kreyenberg, A. von Stackelberg, M. Schrappe, G. Zugmaier, T. Feuchtinger, P. Lang, R. Handgretinger, M. Ebinger   +14 more
semanticscholar   +1 more source

The prognosis of CALM-AF10-positive adult T-cell acute lymphoblastic leukemias depends on the stage of maturation arrest

Haematologica, 2013
CALM-AF10 (also known as PICALM-MLLT10) is the commonest fusion protein in T-cell acute lymphoblastic leukemia, but its prognostic impact remains unclear.
Raouf Ben Abdelali, Vahid Asnafi, Arnaud Petit, Jean-Baptiste Micol, Céline Callens, Patrick Villarese, Eric Delabesse, Oumedaly Reman, Stephane Lepretre, Jean-Yves Cahn, Gaelle Guillerm, Céline Berthon, Claude Gardin, Bernadette Corront, Thibaut Leguay, Marie-Christine Béné, Norbert Ifrah, Guy Leverger, Hervé Dombret, Elizabeth Macintyre   +19 more
doaj   +1 more source

Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome.

New England Journal of Medicine, 2001
BACKGROUND BCR-ABL, a constitutively activated tyrosine kinase, is the product of the Philadelphia chromosome. This enzyme is present in virtually all cases of chronic myeloid leukemia (CML) throughout the course of the disease, and in 20 percent of ...
B. Druker, C. Sawyers, H. Kantarjian, D. Resta, Sofia Fernandes Reese, J. Ford, R. Capdeville, M. Talpaz   +7 more
semanticscholar   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source