Results 41 to 50 of about 577,742 (361)

Prognostic implications of mutations and expression of the Wilms tumor 1 (WT1) gene in adult acute T-lymphoblastic leukemia

Haematologica, 2010
Background The role of the Wilms tumor 1 gene (WT1) in acute leukemias has been underscored by mutations found in acute myeloid leukemia identifying patients with inferior survival.
Sandra Heesch, Nicola Goekbuget, Andrea Stroux, Jutta Ortiz Tanchez, Cornelia Schlee, Thomas Burmeister, Stefan Schwartz, Olga Blau, Ulrich Keilholz, Antonia Busse, Dieter Hoelzer, Eckhard Thiel, Wolf-Karsten Hofmann, Claudia D. Baldus   +13 more
doaj   +1 more source

Acute Lymphoblastic Leukemia [PDF]

Journal of the National Comprehensive Cancer Network, 2012
The inaugural NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for acute lymphoblastic leukemia (ALL) were developed as a result of meetings convened by a multi-disciplinary panel of experts in 2011. These NCCN Guidelines provide recommendations on the diagnostic evaluation and workup for ALL, risk assessment, risk-stratified treatment ...
Naresh Bellam, Michael Millenson, Geoffrey L. Uy, Lloyd E. Damon, Meir Wetzler, Kristina M. Gregory, Stephanie A. Terezakis, Steven Coutre, Patricia Aoun, Arati V. Rao, Susan O'Brien, Maoko Naganuma, Jennifer Cultrera, Joseph C. Alvarnas, Hetty E. Carraway, Michael Boyer, Daniel J. DeAngelo, Peter F. Coccia, Salil Goorha, Dan Douer, Stephen H. Petersdorf, William Blum, Olga Frankfurt, Patrick A. Brown, Andrew D. Zelenetz, Karen K. Ballen, Haydar Frangoul   +26 more
openaire   +3 more sources

Precision medicine in acute lymphoblastic leukemia

Frontiers in Medicine, 2020
The cure rate of childhood acute lymphoblastic leukemia (ALL) has exceeded 90% in some contemporary clinical trials. However, the dose intensity of conventional chemotherapy has been pushed to its limit.
C. Pui
semanticscholar   +1 more source

A case report of secondary B-cell acute lymphoblastic leukemia treated with a combination of FLT3 inhibitor and decitabine

Frontiers in Oncology
Secondary acute lymphoblastic leukemia (s-ALL) refers to acute lymphoblastic leukemia that occurs after a previous malignant tumor, including therapy-related acute lymphoblastic leukemia (t-ALL) and prior malignant tumor acute lymphoblastic leukemia (pm ...
Mengci Hu, Wenzhe Li, Pan Li, Jie Tan, Ya Wang, Ya Wang   +5 more
doaj   +1 more source

Attenuated measles virus controls pediatric acute B-lineage lymphoblastic leukemia in NOD/SCID mice

Haematologica, 2014
Novel therapies are needed for pediatric acute lymphoblastic leukemia resistant to conventional therapy. While emerging data suggest leukemias as possible targets of oncolytic attenuated measles virus, it is unknown whether measles virus can eradicate ...
Nike C. Lühl, Felix Zirngibl, Carmen Dorneburg, Jiwu Wei, Meike Dahlhaus, Thomas F.E. Barth, Lüder H. Meyer, Manon Queudeville, Sarah Eckhoff, Klaus-Michael Debatin, Christian Beltinger   +10 more
doaj   +1 more source

Correlation of Serum Lipoproteins with the Activity of Acute Lymphoblastic Leukaemia

مجله كليه طب الكندي, 2019
Background: the activity of acute lymphoblastic leukemia had been observed to correlate with levels of serum lipoproteins Objective: to evaluate the correlation of serum levels of different types of lipoproteins with activity of the disease in ...
Azher Sebieh Al-Zubaidy
doaj   +1 more source

THE GENOMIC LANDSCAPE OF PEDIATRIC AND YOUNG ADULT T-LINEAGE ACUTE LYMPHOBLASTIC LEUKEMIA

Nature Genetics, 2017
Genetic alterations that activate NOTCH1 signaling and T cell transcription factors, coupled with inactivation of the INK4/ARF tumor suppressors, are hallmarks of T-lineage acute lymphoblastic leukemia (T-ALL), but detailed genome-wide sequencing of ...
Yu Liu, J. Easton, Ying Shao, J. Maciaszek, Zhaoming Wang, M. Wilkinson, K. McCastlain, Michael N. Edmonson, S. Pounds, Lei Shi, Xin Zhou, Xiaotu Ma, Edgar Sioson, Yongjin Li, Michael C. Rusch, P. Gupta, Deqing Pei, Cheng Cheng, Malcolm A. Smith, J. G. Auvil, D. Gerhard, M. Relling, N. Winick, A. Carroll, N. Heerema, E. Raetz, M. Devidas, C. Willman, R. Harvey, W. Carroll, K. Dunsmore, S. Winter, B. Wood, B. Sorrentino, J. Downing, M. Loh, S. Hunger, Jinghui Zhang, C. Mullighan   +38 more
semanticscholar   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Replication analysis confirms the association of ARID5B with childhood B-cell acute lymphoblastic leukemia

Haematologica, 2010
Although childhood acute lymphoblastic leukemia is the most common pediatric cancer, its etiology remains poorly understood. In an attempt to replicate the findings of 2 recent genome-wide association studies in a French-Canadian cohort, we confirmed the
Jasmine Healy, Chantal Richer, Mathieu Bourgey, Ekaterini A. Kritikou, Daniel Sinnett   +4 more
doaj   +1 more source

Semisynthetic aurones A14 protects against T-cell acute lymphoblastic leukemia via suppressing proliferation and inducing cell cycle arrest with apoptosis

Chinese Medicine, 2022
Background Acute lymphoblastic leukemia is an aggressive neoplasm and seriously threatens human health. A14 is one kind of semisynthetic aurone that exhibits the capability to inhibit prostate cancer, but little is known about the role of A14 on T-cell ...
Meng Wang, Lisi Li, Tengyun Fan, Lixue Cao, Jiayi Zhang, Shuang Li, Chunming Liu, Xifu Liu   +7 more
doaj   +1 more source