Results 81 to 90 of about 555,062 (342)

Label‐Free FET Based Biosensor for Detection of Engineered CAR T‐Cells at Single Cell Resolution

Advanced Sensor Research, EarlyView.
A silicon nanowire field‐effect transistor (SiNW FET) biosensor that allows for label‐free, real‐time detection and quantification of engineered Chimeric Antigen Receptor (CAR) T‐cells at single‐cell resolution is presented. By mimicking the CAR‐specific antigen interface, the platform provides highly selective analysis of individual cell surface ...
Trang Anh Nguyen‐Le, Isli Cela, Anja Feldmann, Chang‐Ki Baek, Michael Bachmann, Larysa Baraban   +5 more
wiley   +1 more source

An investigation into whether deletions in 9p reflect prognosis in adult precursor B-cell acute lymphoblastic leukemia: a multi-center study of 381 patients

Haematologica, 2008
In acute lymphoblastic leukemia, besides age and white cell count at diagnosis, the cytogenetic abnormalities t(9;22)/BCR-ABL and t(4;11)/MLL-AF4 are important prognostic markers and are often included in the treatment stratification of patients with ...
Hareth Nahi, Hans Hägglund, Thomas Ahlgren, Per Bernell, Mats Hardling, Karin Karlsson, Vladimir Lj Lazarevic, Mats Linderholm, Bengt Smedmyr, Maria Åström, Helene Hallböök   +10 more
doaj   +1 more source

Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.

New England Journal of Medicine, 2014
BACKGROUND Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is characterized by a gene-expression profile similar to that of BCR-ABL1-positive ALL, alterations of lymphoid transcription factor genes, and a poor outcome.
K. Roberts, Yongjin Li, D. Payne-Turner, R. Harvey, Yung‐Li Yang, Deqing Pei, K. McCastlain, L. Ding, Charles Lu, Guangchun Song, Jing Ma, J. Becksfort, Michael C. Rusch, Shann-Ching Chen, J. Easton, Jinjun Cheng, Kristy Boggs, Natalia Santiago-Morales, I. Iacobucci, R. Fulton, Ji-Rong Wen, M. Valentine, Cheng Cheng, S. Paugh, M. Devidas, I. Chen, S. Reshmi, Amy A. Smith, Erin K. Hedlund, P. Gupta, Panduka Nagahawatte, Gang Wu, Xiang Chen, D. Yergeau, Bhavin Vadodaria, H. Mulder, N. Winick, E. Larsen, W. Carroll, N. Heerema, A. Carroll, G. Grayson, S. Tasian, A. Moore, F. Keller, Melissa J. Frei-Jones, J. Whitlock, E. Raetz, D. White, T. Hughes, Jaime M Guidry Auvil, Malcolm A. Smith, G. Marcucci, C. Bloomfield, K. Mrózek, J. Kohlschmidt, W. Stock, S. Kornblau, M. Konopleva, E. Paietta, C. Pui, S. Jeha, M. Relling, W. Evans, D. Gerhard, J. Gastier-Foster, E. Mardis, R. Wilson, M. Loh, J. Downing, S. Hunger, C. Willman, Jinghui Zhang, C. Mullighan   +73 more
semanticscholar   +1 more source

PTPN2 Inhibition Disrupts Mitochondrial Renewal and Blocks TFRC‐Mediated Mitophagy to Exert Anti‐Tumor Activities in ALK‐Positive Anaplastic Large Cell Lymphoma

Advanced Science, EarlyView.
CRISPR/Cas9 screening reveals PTPN2 as essential for ALK+ ALCL survival. PTPN2 regulates TFRC to promote PINK1‐PRKN mitophagy. Oral PTPN2 inhibitor ABBV‐CLS‐484 disrupts mitochondrial renewal and blocks TFRC‐mediated mitophagy to exert anti‐tumor activities, supporting clinical development for ALK+ ALCL.
Wei‐Ting Wang, Zi‐Wen Duan, Tong‐Yao Xing, Wei Hua, Kai‐Xing Du, Chun‐Yu Shang, Yi‐Fan Wu, Li Wang, Jian‐Yong Li, Rui Gao, Jin‐Hua Liang, Wei Xu   +11 more
wiley   +1 more source

Hospital acquired pneumonia risk factors in children with Acute Lymphoblastic Leukemia on chemotherapy

Heliyon, 2021
Background: Over the past 10 years, infection has remained as the main cause of illness and mortality among children with Acute Lymphoblastic Leukemia on chemotherapy. The high incidence of Hospital-Acquired Pneumonia in children with Acute Lymphoblastic
Anitha Marllyin Mairuhu, Mia Ratwita Andarsini, Retno Asih Setyoningrum, Andi Cahyadi, Maria Christina Shanty Larasati, I.Dewa Gede Ugrasena, Bambang Permono, Satrio Budiman   +7 more
doaj  

Classification of acute lymphoblastic leukemia using deep learning

Microscopy research and technique (Print), 2018
Acute Leukemia is a life‐threatening disease common both in children and adults that can lead to death if left untreated. Acute Lymphoblastic Leukemia (ALL) spreads out in children's bodies rapidly and takes the life within a few weeks.
A. Rehman, Naveed Abbas, T. Saba, Syed Ijaz Ur Rahman, Zahid Mehmood, H. Kolivand   +5 more
semanticscholar   +1 more source

Engineered Foxp1high Exosomes Ameliorates Systemic Lupus Erythematosus

Advanced Science, EarlyView.
This study presents a dual‐engineering strategy combining mesenchymal stem cell aggregation and Foxp1 overexpression to generate Foxp1high aggregation exosomes with enhanced immunomodulatory properties. These engineered exosomes exhibit immune organ targeting and superior efficacy in systemic lupus erythematosus treatment by promoting Treg ...
Luhan Niu, Qianmin Ou, Qianhui Ren, Zhengshi Li, Hongcheng Chen, Fangcao Lei, Xueli Mao, Songtao Shi, Zetao Chen, Wei Teng   +9 more
wiley   +1 more source

Marrow transplantation for patients with acute lymphoblastic leukemia in remission [PDF]

, 1979
Thomas Ed, JE Sanders, Nancy Flournoy, F L Johnson, CD Buckner, Clift Ra, A Fefer, BW Goodell, R Storb, PL Weiden   +9 more
openalex   +3 more sources

How I Treat Newly Diagnosed T-cell Acute Lymphoblastic Leukemia (T-ALL) and T-cell Lymphoblastic Lymphoma in Children.

Blood, 2019
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy that has historically been associated with a very poor prognosis. Nevertheless, despite a lack of incorporation of novel agents, the development of intensified T-ALL focused ...
D. Teachey, D. O’Connor
semanticscholar   +1 more source

Molecular diagnosis of lymphoblastic leukemia

Journal of Cancer Research and Therapeutics, 2013
The mixed lineage leukemia (MLL) gene at chromosome band 11q23 is commonly involved in reciprocal translocations that is detected in acute leukemia. The MLL gene, commonly known as mixed lineage leukemia or myeloid lymphoid leukemia, has been independently identified and cloned from the 11q23 breakpoint of acute leukemia.
Seetha Dayakar, Kalal Iravathy Goud, Amina Shaik, S.V.S. Prasad, S Vanjakshi, Koteshwar N Rao   +5 more
openaire   +3 more sources