Results 81 to 90 of about 139,045 (309)

Frequencies and prognostic impact of RAS mutations in MLL-rearranged acute lymphoblastic leukemia in infants

Haematologica, 2013
Acute lymphoblastic leukemia in infants represents an aggressive malignancy associated with a high incidence (approx. 80%) of translocations involving the Mixed Lineage Leukemia (MLL) gene.
Emma M.C. Driessen, Eddy H.J. van Roon, Jill A.P. Spijkers-Hagelstein, Pauline Schneider, Paola de Lorenzo, Maria Grazia Valsecchi, Rob Pieters, Ronald W. Stam   +7 more
doaj   +1 more source

Logic‐Gated HSV‐TK/GCV Suicide Gene Circuit for Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
The BRAS comprises two modular genetic components driven by distinct tumor‐specific promoters and a failsafe layer with the NOT gate. This multi‐input logic gate circuit enables precise, specific expression of HSV‐TK in breast cancer cells with hardly expression in normal cell and effectively inhibits tumor growth in a triple‐negative breast cancer ...
Shasha Tang, Yuan Fang, Lingli Jin, Dongyang Liu, Yicheng Liu, Ruijia Zheng, Liyun Yong, Xin Wu, Longliang Qiao, Meiyan Wang, Fengfeng Cai   +10 more
wiley   +1 more source

The Notch driven long non-coding RNA repertoire in T-cell acute lymphoblastic leukemia

Haematologica, 2014
Genetic studies in T-cell acute lymphoblastic leukemia have uncovered a remarkable complexity of oncogenic and loss-of-function mutations. Amongst this plethora of genetic changes, NOTCH1 activating mutations stand out as the most frequently occurring ...
Kaat Durinck, Annelynn Wallaert, Inge Van de Walle, Wouter Van Loocke, Pieter-Jan Volders, Suzanne Vanhauwaert, Ellen Geerdens, Yves Benoit, Nadine Van Roy, Bruce Poppe, Jean Soulier, Jan Cools, Pieter Mestdagh, Jo Vandesompele, Pieter Rondou, Pieter Van Vlierberghe, Tom Taghon, Frank Speleman   +17 more
doaj   +1 more source

Sulfate‐Directed Silver Dendrites with Enhanced Stability for Ultrasensitive SERS‐Based Therapeutic Drug Monitoring

Advanced Science, EarlyView.
This study presents sulfate‐directed silver dendrites (s‐AgDs) as oxidation‐resistant SERS substrates with long‐term stability, reproducibility, and sub‐picomolar sensitivity. Sulfate ions guide anisotropic growth and protect the surface, enabling improved performance over 7 months under ambient conditions.
Aradhana Dwivedi, Jan Dellith, Anna Makarova, Samir F. El‐Mashtoly, Juergen Popp, Vladimir Sivakov, Dana Cialla‐May   +6 more
wiley   +1 more source

Intensified therapy for infants with acute lymphoblastic leukemia [PDF]

, 1997
Lewis B. Silverman, Thomas W. McLean, Richard D. Gelber, Mia J. Donnelly, D. Gary Gilliland, Nancy J. Tarbell, Stephen E. Sallan   +6 more
openalex   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Novel gene targets detected by genomic profiling in a consecutive series of 126 adults with acute lymphoblastic leukemia

Haematologica, 2015
In contrast to acute lymphoblastic leukemia in children, adult cases of this disease are associated with a very poor prognosis. In order to ascertain whether the frequencies and patterns of submicroscopic changes, identifiable with single nucleotide ...
Setareh Safavi, Markus Hansson, Karin Karlsson, Andrea Biloglav, Bertil Johansson, Kajsa Paulsson   +5 more
doaj   +1 more source

A New Treatment Strategy for Early T‐Cell Precursor Acute Lymphoblastic Leukemia: A Case Report and Literature Review

, 2021
Jianping Mao, Lian-Guo Xue, Haiqing Wang, Yuanxin Zhu, Juan Wang, Lidong Zhao   +5 more
openalex   +2 more sources

Dynamic Decoration of DNA Scaffolds for High‐Resolution Cancer Cell Subtyping

Advanced Science, EarlyView.
This study presents a dual‐mode imaging platform that utilizes self‐assembly and disassembly of DNA scaffolds for high‐resolution cancer cell detection. The structural rigidity of DNA scaffolds effectively prevents cellular internalization for over 300 min.
Xiaolin Hu, Jie Xie, Xinlin Guo, Liangting Wang, Zhengheng Yu, Xiaopei Qiu, Heng Li, Kang Wang, Xiaoxing Wang, Mingxuan Song, Junsong Guo, Wei Gu, Sergio Bernardini, Chaoyong Yang, Hong Zhang, Yang Luo   +15 more
wiley   +1 more source

Mutations of PHF6 are associated with mutations of NOTCH1, JAK1 and rearrangement of SET-NUP214 in T-cell acute lymphoblastic leukemia

Haematologica, 2011
Background Mutations in the PHF6 gene were recently described in patients with T-cell acute lymphoblastic leukemia and in those with acute myeloid leukemia.
Qian Wang, Huiying Qiu, Hui Jiang, Lili Wu, Shasha Dong, Jinlan Pan, Wenjuan Wang, Nana Ping, Jing Xia, Aining Sun, Depei Wu, Yongquan Xue, Hans G. Drexler, Roderick A. F. MacLeod, Suning Chen   +14 more
doaj   +1 more source