Results 231 to 240 of about 88,752 (299)

The Prognostic Value of Neutrophil-to-Lymphocyte Ratio and Lymphocyte-to-Monocyte Ratio in Patients with Hepatocellular Carcinoma Receiving HAIC-Based Conversion Hepatectomy: A Dual-Center Retrospective Cohort Study. [PDF]

J Inflamm Res
Li D, Fan Y, He B, Tang Y, Deng G, Guo R, Deng M, Tang D.   +7 more
europepmc   +1 more source

Leukocytosis and tobacco use during pregnancy

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective Factors such as tobacco and other toxic substance use, obesity, associated comorbidity, and intercurrent infections can cause a proinflammatory state and modify analytical parameters. The objective of this study is to identify smoking‐induced leukocytosis in pregnant women across all three trimesters of pregnancy to aid in their ...
Nayara López Carpintero, Carolina Giráldez‐García, Rodrigo Carmona Camacho   +2 more
wiley   +1 more source

The association between the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio and delirium in ischemic stroke patients. [PDF]

Front Med (Lausanne)
Wang P, Huang J, Xu L, Hu R.
europepmc   +1 more source

Spatial multi‐omics identifies a NOTCH3‐mediated capillary–mCAF crosstalk driving immune exclusion in hepatocellular carcinoma

iMeta, EarlyView.
Spatial multi‐omics defines a DLL4–NOTCH3–driven capillary–mCAF axis orchestrating fibrotic remodeling and immune exclusion in hepatocellular carcinoma tumor cores, conferring immune checkpoint blockade resistance. Targeting stromal NOTCH3 disrupts this pro‐fibrotic niche, enhances T cell infiltration, and synergizes with anti‐PD‐1 therapy ...
Fansen Ji, Haochen Li, Qi Wang, Xiaojuan Wang, Jiawei Zhang, Ying Xiao, Huan Li, Hao Liu, Tanqing Long, Boyang Wu, Hao Chen, Haoming Xia, Xinquan Liu, Chuanrui Xu, Yibo Gao, Bingjun Tang, Juan Liu, Shizhong Yang, Jiahong Dong   +18 more
wiley   +1 more source

Predicting cardiovascular disease and all-cause mortality using the lymphocyte-to-monocyte ratio: Insights from explainable machine learning models. [PDF]

Int J Cardiol Cardiovasc Risk Prev
Wu J, Huang D, Li J, Yi J, Lei Y, Yin J.
europepmc   +1 more source

Targeting DGKα/PA axis inhibits tumor immune evasion and augments sensitivity to immunotherapy in gastrointestinal cancers

iMeta, EarlyView.
Immune checkpoint inhibitors (ICIs) have shown promising antitumor efficacy in certain types of solid tumors. However, the efficacy of ICIs remains unsatisfactory owing to the dysregulation of signaling pathways in local tumor tissues. Here, we reveal that diacylglycerol kinase α (DGKα)‐derived phosphatidic acid (PA) directly binds to nuclear factor‐κB
Jie Chen, Siqi Liu, Ting Peng, Fenglong Wang, Yuheng Zhu, Jingyuan Pang, Qingnan Wu, Yan Wang, Qimin Zhan   +8 more
wiley   +1 more source

Utility of lymphocyte-to-monocyte ratio and pretreatment tooth extraction in intra-arterial chemoradiotherapy for oral cancer to prevent osteoradionecrosis of the jaw. [PDF]

Sci Rep
Kubota K, Furudate K, Ito R, Narita N, Tanaka Y, Tamura Y, Takagi K, Yamazaki S, Matsumura A, Matsumiya T, Kobayashi W.   +10 more
europepmc   +1 more source

A large‐scale single‐cell transcriptomic atlas indicates the immune panorama of influenza A infection

iMeta, EarlyView.
The study presents a large‐scale single‐cell transcriptomic atlas profiling over 612,010 peripheral immune cells from 97 individuals to decode the heterogeneity of influenza infection. These findings indicate a fundamental immune dichotomy determining clinical trajectories: a protective, monocyte‐centric antiviral state in mild disease versus a ...
Yi Wang, Shuzi Liu, Laurence Don Wai Luu, Yongzhi Zhai, Chenliang Zhu, Zhaomin Feng, Yao Tan, Linglong Wan, Jie Wang, Juan Zhou, Jing Wang, Lixin Xie, Quanyi Wang, Fei Xie   +13 more
wiley   +1 more source

The Role and Therapeutic Potential of Voltage‐Gated Potassium Channel Kv1.3 in Metabolism‐Related Disorders

iNew Medicine, EarlyView.
ABSTRACT Over the past three decades, the global burden of common metabolic diseases such as obesity, diabetes, and atherosclerosis has steadily increased, becoming a serious public health issue that poses a major threat to human health worldwide. Potassium channels, particularly the voltage‐gated Kv1.3 subtype, serve as critical regulators of cellular
Wenjun Zhen, Junda Liu, Xixi Chen, Shi Chen, Yuanyuan Tian, Baoming Wu, Fengxia Yan   +6 more
wiley   +1 more source

Peripheral Lymphocyte-to-Monocyte Ratio as a Predictive Factor for Early Neurological Deterioration in Patients with Acute Ischemic Stroke. [PDF]

Int J Gen Med
Sun L, Ye X, Yu J, Wang L, Wu Y, Cui J, Dai L.   +6 more
europepmc   +1 more source