Results 31 to 40 of about 773,144 (311)

Structure of mammalian Mediator complex reveals Tail module architecture and interaction with a conserved core

open access: yesNature Communications, 2021
The Mediator complex regulates RNA polymerase II transcription in all eukaryotes. The mammalian Mediator cryo-EM structure reveals the architecture of previously unresolved Tail module and suggests its regulatory role in the complex conformation and ...
Haiyan Zhao   +6 more
doaj   +1 more source

Activation of lymphocytes [PDF]

open access: yesJournal of Clinical Pathology, 1967
The technique involved in studying the activation of lymphocytes in the resting form, and their recognition as dividing and functional cells was studied, using phase contrast and agar as well as fluid culture. Standardization of technical methods was found to be essential, and the effect of variables was studied.
R J, Pulvertaft, I, Pulvertaft
openaire   +2 more sources

CCCTC-Binding Factor Locks Premature IgH Germline Transcription and Restrains Class Switch Recombination

open access: yesFrontiers in Immunology, 2017
In response to antigenic stimulation B cells undergo class switch recombination (CSR) at the immunoglobulin heavy chain (IgH) to replace the primary IgM/IgD isotypes by IgG, IgE, or IgA.
Ester Marina-Zárate   +2 more
doaj   +1 more source

Lymphocytic gastritis [PDF]

open access: yesPolish Journal of Pathology, 2019
Organic basis of gastrointestinal symptoms is in the scope of many specialists. In this article lymphocytic gastritis, relatively newly described and not widely-known entity is presented. The lesion is characterized by presence of numerous mature lymphocytes in the surface and foveolar epithelium, as well as lymphocytic infiltration of the lamina ...
Michał Puderecki   +3 more
openaire   +4 more sources

Prognostic Utility of Platelet–Lymphocyte Ratio, Neutrophil–Lymphocyte Ratio and Monocyte–Lymphocyte Ratio in Head and Neck Cancers: A Detailed PRISMA Compliant Systematic Review and Meta-Analysis

open access: yes, 2021
Inflammation plays a major role in cancer development and progression and has the potential to be used as a prognostic marker in cancer. Previous studies have attempted to evaluate Platelet-to-lymphocyte ratio (PLR), neutrophil–lymphocyte ratio (NLR) or ...
Sunil, Krishnan   +15 more
core   +1 more source

Inherited immunodeficiencies associated with proximal and distal defects in T cell receptor signaling and co-signaling

open access: yesBiomedical Journal, 2022
T lymphocytes are central cells of adaptive immunity. Activation of T lymphocytes by the antigen receptor of T cells (TCR) and co-stimulatory molecules involve specific signaling components and cascades.
Sylvain Latour
doaj   +1 more source

Lymphocytes in atherosclerosis [PDF]

open access: yesClinica Chimica Acta, 2012
It is well established that atherosclerosis is caused by an inflammatory process in the arterial intima. However, it is only in recent years that it has become clear that this inflammation is modulated by immune responses against plaque antigens. These antigens are primarily believed to be modified self-antigens such as oxidized LDL.
Wigren, Maria   +2 more
openaire   +3 more sources

Lymphocyte subsets and the role of Th1/Th2 balance in stressed chronic pain patients [PDF]

open access: yes, 2007
Background: The complex regional pain syndrome (CRPS) and fibromyalgia (FM) are chronic pain syndromes occurring in highly stressed individuals. Despite the known connection between the nervous system and immune cells, information on distribution of ...
Beyer, Antje   +7 more
core   +1 more source

Tuning of in vivo cognate B-T cell interactions by Intersectin 2 is required for effective anti-viral B cell immunity

open access: yeseLife, 2018
Wiskott-Aldrich syndrome (WAS) is an immune pathology associated with mutations in WAS protein (WASp) or in WASp interacting protein (WIP). Together with the small GTPase Cdc42 and other effectors, these proteins participate in the remodelling of the ...
Marianne Burbage   +8 more
doaj   +1 more source

Mean Platelet Volume, Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio to Predict Complications During Postoperative Recovery of High Risk Surgical Patients [PDF]

open access: yes, 2021
Objective:This study sought to define the correlation between the occurrence of the complications and certain blood parameters in high risk surgical patients who were monitored for 24 hours in the intensive care unit postoperatively.Method:Two hundred ...
Gülsüm Oya Hergünsel   +5 more
core   +1 more source

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