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The persistence of human peripheral lymphocytes, tumor infiltrating lymphocytes, and colon adenocarcinomas in immunodeficient mice.

Journal of immunotherapy, 1992
The reconstitution of severely immunodeficient mice with human peripheral blood mononuclear cells (PBMCs) may represent a unique model system to evaluate human antitumor responses. To evaluate this possibility, we studied human PBMC reconstitution, human
D. Jicha   +6 more
semanticscholar   +1 more source

Prognostic Nutritional Index, Tumor-infiltrating Lymphocytes, and Prognosis in Patients with Esophageal Cancer.

Annals of Surgery, 2020
OBJECTIVE To determine whether prognostic nutritional index (PNI) affects clinical outcome through local immunity in esophageal cancers. BACKGROUND PNI is an indicator of nutritional status and systemic immune competence, and has attracted attention as
K. Okadome   +9 more
semanticscholar   +1 more source

Tumor‐infiltrating lymphocytes in breast FNA biopsy cytology: A predictor of tumor‐infiltrating lymphocytes in histologic evaluation

Cancer Cytopathology, 2022
BackgroundTumor‐infiltrating lymphocytes (TILs) are associated with various clinicopathological features. Using cytologic specimens for assessing TILs remains to be established. This retrospective study aimed to establish a practical method to assess TILs in cytologic samples.MethodsThe authors found 1101 breast fine‐needle aspiration biopsy (FNAB ...
Toru Odate   +5 more
openaire   +2 more sources

Tumor-Infiltrating Lymphocytes

The Cancer Journal, 2015
Adoptive cell therapy (ACT) with tumor-infiltrating lymphocytes (TILs) in combination with lymphodepletion and high-dose interleukin 2 has shown reproducible objective response rates of approximately 50% in patients with highly advanced, refractory metastatic melanoma.
Ronnie Shapira-Frommer   +2 more
openaire   +3 more sources

Computational recognition of lncRNA signature of tumor-infiltrating B lymphocytes with potential implications in prognosis and immunotherapy of bladder cancer

Briefings Bioinform., 2020
Long noncoding RNAs (lncRNAs) have been associated with cancer immunity regulation and the tumor microenvironment (TME). However, functions of lncRNAs of tumor-infiltrating B lymphocytes (TIL-Bs) and their clinical significance have not yet been fully ...
Meng Zhou   +6 more
semanticscholar   +1 more source

Clonal dynamics of tumor-infiltrating lymphocytes

European Journal of Immunology, 2005
The presence of tumor-infiltrating lymphocytes (TIL) provides important evidence of anti-tumor immunity in vivo. However, TIL are usually not sufficient for inhibiting tumor growth. We explored the spatial and temporal aspects of clonal accumulation of TIL using RT-PCR/single-strand conformation polymorphism analysis.
Hiroyuki Tahara   +4 more
openaire   +3 more sources

Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer.

Journal of the American Medical Association (JAMA)
Importance The association of tumor-infiltrating lymphocyte (TIL) abundance in breast cancer tissue with cancer recurrence and death in patients with early-stage triple-negative breast cancer (TNBC) who are not treated with adjuvant or neoadjuvant ...
R. Leon-Ferre   +32 more
semanticscholar   +1 more source

Tumor-Infiltrating Lymphocytes

Acta Cytologica, 1996
To characterize the cytologic, phenotypic and morphometric features of tumor-infiltrating lymphocytes (TILs).Morphology and cell size parameters of 50 TILs and five normal donor peripheral blood lymphocyte (PBL) specimens were compared using light microscopy, manual ocular measurements and digital image processing.Cytologically, all TILs demonstrated ...
Diane Solomon   +2 more
openaire   +3 more sources

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