Results 321 to 330 of about 311,006 (351)

Tumor-Infiltrating Lymphocytes

The Cancer Journal, 2015
Adoptive cell therapy (ACT) with tumor-infiltrating lymphocytes (TILs) in combination with lymphodepletion and high-dose interleukin 2 has shown reproducible objective response rates of approximately 50% in patients with highly advanced, refractory metastatic melanoma.
Ronnie Shapira-Frommer, Jacob Schachter, Michal J. Besser   +2 more
openaire   +3 more sources

Computational recognition of lncRNA signature of tumor-infiltrating B lymphocytes with potential implications in prognosis and immunotherapy of bladder cancer

Briefings Bioinform., 2020
Long noncoding RNAs (lncRNAs) have been associated with cancer immunity regulation and the tumor microenvironment (TME). However, functions of lncRNAs of tumor-infiltrating B lymphocytes (TIL-Bs) and their clinical significance have not yet been fully ...
Meng Zhou, Zicheng Zhang, S. Bao, P. Hou, Congcong Yan, Jianzhong Su, Jie Sun   +6 more
semanticscholar   +1 more source

Clonal dynamics of tumor-infiltrating lymphocytes

European Journal of Immunology, 2005
The presence of tumor-infiltrating lymphocytes (TIL) provides important evidence of anti-tumor immunity in vivo. However, TIL are usually not sufficient for inhibiting tumor growth. We explored the spatial and temporal aspects of clonal accumulation of TIL using RT-PCR/single-strand conformation polymorphism analysis.
Hiroyuki Tahara, Kazuhiko Yamamoto, Keishi Fujio, Rong Yu, Yasuto Araki   +4 more
openaire   +3 more sources

Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer.

Journal of the American Medical Association (JAMA)
Importance The association of tumor-infiltrating lymphocyte (TIL) abundance in breast cancer tissue with cancer recurrence and death in patients with early-stage triple-negative breast cancer (TNBC) who are not treated with adjuvant or neoadjuvant ...
R. Leon-Ferre, S. Jonas, R. Salgado, S. Loi, V. D. de Jong, Jodi M Carter, Torsten O. Nielsen, Samuel Leung, N. Riaz, Stephen K. L. Chia, Gerome Jules-Clement, G. Curigliano, C. Criscitiello, Vincent Cockenpot, M. Lambertini, Vera J Suman, B. Linderholm, John W. M. Martens, C. V. van Deurzen, A. M. Timmermans, T. Shimoi, S. Yazaki, Masayuki Yoshida, Sung-Bae Kim, Hee Jin Lee, M. Dieci, Guillaume Bataillon, A. Vincent-Salomon, Fabrice André, M. Kok, Sabine C. Linn, M. Goetz, S. Michiels   +32 more
semanticscholar   +1 more source

Tumor-Infiltrating Lymphocytes

Acta Cytologica, 1996
To characterize the cytologic, phenotypic and morphometric features of tumor-infiltrating lymphocytes (TILs).Morphology and cell size parameters of 50 TILs and five normal donor peripheral blood lymphocyte (PBL) specimens were compared using light microscopy, manual ocular measurements and digital image processing.Cytologically, all TILs demonstrated ...
Diane Solomon, Gary W. Oliver, John Yannelli   +2 more
openaire   +3 more sources

Reporting Tumor Infiltrating Lymphocytes

2012
The presence of many tumor infiltrating lymphocytes (TILs) in primary cutaneous melanoma is associated with a better prognosis. The degree of lymphocytic interaction with the tumor cells is graded as “brisk”, “non-brisk” or “absent” as defined below:
Kasia Szyfelbein Masterpol, Lyn M. Duncan, Andrea Primiani   +2 more
openaire   +2 more sources

Tumor-infiltrating lymphocytes and POLE mutation in endometrial carcinoma

Gynecologic Oncology, 2021
Polymerase-ε (POLE)-mutated endometrial carcinomas (ECs) have displayed an increased number of tumor-infiltrating lymphocytes (TIL) compared to POLE-wild-type ECs. However, it is unclear if TIL may aid in identifying POLE-mutated ECs when molecular data are unavailable.
Raffone A., Travaglino A., Raimondo D., Boccellino M. P., Maletta M., Borghese G., Casadio P., Insabato L., Mollo A., Zullo F., Seracchioli R.   +10 more
openaire   +5 more sources

Tumor-Infiltrating Lymphocyte Therapy and Neoantigens

The Cancer Journal, 2017
The adoptive cell transfer (ACT) of autologous tumor-infiltrating lymphocytes has been shown to be effective at mediating tumor regression in more than half of patients with metastatic melanoma and in mediating long-term complete regression in approximately one fourth of all patients with this cancer.
openaire   +3 more sources

Clinical Significance of Tumor-Infiltrating Lymphocytes in Lung Neoplasms [PDF]

The Annals of Thoracic Surgery, 2009
Tumor-infiltrating lymphocytes (TIL) are considered important in anticancer immunosurveillance, although their role has not been clearly established yet. We examined prevalence, correlations, and prognostic significance of TIL among our patient population of resected lung neoplasms.From 1993 to 2006, the presence of TIL was retrospectively evaluated in
RUFFINI, Enrico, ASIOLI, Sofia, FILOSSO, Pier Luigi, Lyberis P, Bruna MC, Macrì L, DANIELE, Lorenzo, OLIARO, Alberto   +7 more
openaire   +3 more sources

Immunotyping and Quantification of Melanoma Tumor–Infiltrating Lymphocytes

2021
The density of tumour-infiltrating lymphocytes (TILs) in melanoma is correlated with improved clinical prognosis; however, standardized TIL immunotyping and quantification protocols are lacking. Herein, we provide a review of the technologies being utilized for the immunotyping and quantification of melanoma TILs.
Zeyad T. Sahli, Max O. Meneveau, Craig L. Slingluff, Ileana S. Mauldin, Kevin T. Lynch   +4 more
openaire   +3 more sources