Results 141 to 150 of about 693,895 (386)

IRF8 Drives Conventional Type 1 Dendritic Cell Differentiation and CD8+ T Cell Activation to Aggravate Abdominal Aortic Aneurysm Development

Advanced Science, EarlyView.
This study highlights the critical role of IRF8 in the development of AAA. IRF8 activation promotes the differentiation of cDC1s, which in turn recruit and activate CD8+ T cells, contributing to aortic wall degradation. The study identifies the IRF8‐cDC1‐CD8+ T cell axis as a key pathway in AAA progression, offering new potential therapeutic targets to
Zhen Yuan, Li Shu, Yidan Zheng, Yidong Wang, Mengsha Zheng, Jie Sun, Jiantao Fu, Zihao Zhou, Shen Song, Zhenjie Liu, Fei Li, Zhejun Cai   +11 more
wiley   +1 more source

Nkx2-3—A Slippery Slope From Development Through Inflammation Toward Hematopoietic Malignancies

Biomarker Insights, 2018
The development of peripheral lymphoid tissues from the mesoderm is the result of a complex convergence combining lymphohematopoietic differentiation with the local specification of nonhematopoietic mesenchymal components.
Dóra Vojkovics, Zoltán Kellermayer, Béla Kajtár, Giovanna Roncador, Áron Vincze, Péter Balogh   +5 more
doaj   +1 more source

AhR‐Dependent Induction of β‐Defensin 1 in Colonic Epithelial Cells Regulates Cross‐Talk between Gut Microbiota and Immune Response Leading to Attenuation of Colitis

Advanced Science, EarlyView.
This study identifies a key signaling pathway involving the environmental sensor AhR and antimicrobial peptides, such as BD‐1, in the regulation of intestinal homeostasis. It highlights the role of BD‐1 in regulating gut microbiota and the intestinal immune response.
Manikandan Palrasu, Amarnath Marudamuthu, Khadija Kakar, Hamida Hamida, Shruthi Thada, Rohan Gupta, Kiesha Wilson, Taylor Carter, Yin Zhong, Archana Saxena, Xiaoming Yang, Narendra Singh, Philip Brandon Busbee, Jie Li, Monica Garcia‐Buitrago, Prakash Nagarkatti, Mitzi Nagarkatti   +16 more
wiley   +1 more source

Studies of Diseases of the Lymphoid and Myeloid Tissues [PDF]

, 1932
Frederic Parker, Henry Jackson, G. Fitz Slaughter Hugh, Tom D. Spies   +3 more
openalex   +1 more source

Human gut-associated lymphoid tissues (GALT); diversity, structure, and function

Mucosal Immunology, 2021
U. Mörbe, Peter B. Jørgensen, Thomas M. Fenton, Nicole von Burg, L. Riis, J. Spencer, W. Agace   +6 more
semanticscholar   +1 more source

DeepCCDS: Interpretable Deep Learning Framework for Predicting Cancer Cell Drug Sensitivity through Characterizing Cancer Driver Signals

Advanced Science, EarlyView.
DeepCCDS leverages prior knowledge and self‐supervised learning to model cancer driver signals for drug sensitivity prediction. It captures complex regulatory patterns enabling more biologically informed representations. The framework outperforms existing methods across datasets, offering improved accuracy and interpretability.
Jiashuo Wu, Jiyin Lai, Xilong Zhao, Ziyi Wang, Yongbao Zhang, Liqiang Wang, Yinchun Su, Yalan He, Siyuan Li, Ying Jiang, Junwei Han   +10 more
wiley   +1 more source

Primary malignant lymphoid tumors of the stomach [PDF]

, 1956
B Thorbjarnarson, John M. Beal, John M. Pearce   +2 more
openalex   +1 more source

Engineered Tissue Models to Decode Host–Microbiota Interactions

Advanced Science, EarlyView.
Host–Microbiota interactions in the human body. Created in BioRender. Ghezzi, C. (2025) https://BioRender.com/ihivskg. Abstract A mutualistic co‐evolution exists between the host and its associated microbiota in the human body. Bacteria establish ecological niches in various tissues of the body, locally influencing their physiology and functions, but ...
Miryam Adelfio, Grace E. Callen, Xuesong He, Bruce J. Paster, Hatice Hasturk, Chiara E. Ghezzi   +5 more
wiley   +1 more source

Distinction of lymphoid and myeloid clonal hematopoiesis

Nature Network Boston, 2021
A. Niroula, Aswin Sekar, Mark A. Murakami, M. Trinder, M. Agrawal, W. Wong, A. Bick, M. Uddin, C. Gibson, G. Griffin, M. Honigberg, S. Zekavat, K. Paruchuri, P. Natarajan, B. Ebert   +14 more
semanticscholar   +1 more source

KK2DP7 Stimulates CD11b+ Cell Populations in the Spleen to Elicit Trained Immunity for Anti‐Tumor Therapy

Advanced Science, EarlyView.
This study introduces KK2DP7, a dendrimer‐structured peptide adjuvant, as a tool to decode trained immunity's role in antitumor therapy. Splenic CD11b+ cells mediate tumor suppression via TLR2‐IRF7 activation and epigenetic reprogramming, validated by adoptive transfer experiments.
Rui Zhang, Lin Tang, Yusi Wang, Xuejing Zhou, Zhenyu Ding, Li Yang   +5 more
wiley   +1 more source