Results 141 to 150 of about 745,482 (386)

Vaccination against H9N2 avian influenza virus reduces bronchus‐associated lymphoid tissue formation in cynomolgus macaques after intranasal virus challenge infection [PDF]

, 2016
Misako Nakayama, Hiroichi Ozaki, Yasushi Itoh, Kosuke Soda, Hirohito Ishigaki, Masatoshi Okamatsu, Yoshihiro Sakoda, Chun-Ho PARK, Hideaki Tsuchiya, Hiroshi Kida, Kazumasa Ogasawara   +10 more
openalex   +1 more source

B cells and tertiary lymphoid structures promote immunotherapy response

Nature, 2020
Beth A. Helmink, S. Reddy, Jianjun Gao, Shaojun Zhang, R. Başar, R. Thakur, Keren Yizhak, Moshe Sade-Feldman, J. Blando, Guangchun Han, V. Gopalakrishnan, Y. Xi, Hao Zhao, R. Amaria, H. Tawbi, Alexandria P. Cogdill, Wenbin Liu, Valerie S. LeBleu, Fernanda G. Kugeratski, S. Patel, M. Davies, P. Hwu, Jeffrey E. Lee, J. Gershenwald, A. Lucci, R. Arora, S. Woodman, E. Keung, P. Gaudreau, A. Reuben, C. Spencer, E. Burton, L. Haydu, A. Lazar, Roberta Zapassodi, C. Hudgens, D. Ledesma, Sufey Ong, M. Bailey, S. Warren, Disha Rao, O. Krijgsman, E. Rozeman, D. Peeper, C. Blank, T. Schumacher, L. Butterfield, M. Zelazowska, Kevin M. McBride, R. Kalluri, J. Allison, F. Petitprez, W. Fridman, C. Sautès-Fridman, N. Hacohen, K. Rezvani, Padmanee Sharma, M. Tetzlaff, Linghua Wang, J. Wargo   +59 more
semanticscholar   +1 more source

Mature tertiary lymphoid structures predict immune checkpoint inhibitor efficacy in solid tumors independently of PD-L1 expression

Nature Cancer, 2021
Lucile Vanhersecke, M. Brunet, J. Guégan, C. Rey, A. Bougouin, S. Cousin, S. Le Moulec, B. Besse, Y. Loriot, Mathieu Larroquette, I. Soubeyran, M. Toulmonde, G. Roubaud, S. Pernot, M. Cabart, F. Chomy, C. Lefevre, K. Bourcier, M. Kind, Ilenia Giglioli, C. Sautès-Fridman, V. Vélasco, Félicie Courgeon, Ezoglin Oflazoglu, A. Savina, A. Marabelle, J. Soria, C. Bellera, C. Sofeu, A. Bessede, W. Fridman, F. Le Loarer, A. Italiano   +32 more
semanticscholar   +1 more source

Epstein‐Barr Virus Expressed Long Non‐Coding RNA (lncBARTs) Regulate EBV Latent Genome Replication

Advanced Science, EarlyView.
EBV produces abundant level of lncBARTs, which are essential for maintaining viral genome replication in EBV‐associated cancers. LncBARTs interact with a complex comprising BRD4, CTCF and viral protein EBNA1 at EBV oriP region. This interaction tethers oriP to host chromosomes, facilitating EBV episome replication.
Jiayan Liu, Dittman Lai‐Shun Chung, Larry Ka‐Yue Chow, Shuo Han, Wenkai Yi, Conor J. Cremin, Yingyin Liao, Pui Wang, Bobo Wing‐Yee Mok, Mingfang Ji, Jian Yan, Wei Dai, Honglin Chen   +12 more
wiley   +1 more source

Human gut-associated lymphoid tissues (GALT); diversity, structure, and function

Mucosal Immunology, 2021
U. Mörbe, Peter B. Jørgensen, Thomas M. Fenton, Nicole von Burg, L. Riis, J. Spencer, W. Agace   +6 more
semanticscholar   +1 more source

Neural Circuits between Nodose Ganglion and Pulmonary Neuroendocrine Cells Regulate Lung Inflammatory Responses

Advanced Science, EarlyView.
TRPA1+αCGRP+ sensory neurons in the nodose ganglion detect external insults such as lipopolysaccharide (LPS) and interact directly with pulmonary neuroendocrine cells (PNECs), promoting their activation and proliferation. This neural‐epithelial interaction amplifies lung inflammation.
Jie Chen, Shitao Xie, Zhekai Lin, Caiqi Zhao, Rujia Tao, Yingying Ma, Xiaoyan Chen, Renlan Wu, Qingjian Han, Pengfei Sui, Sheng Wang, Hongbin Ji, Hai Song, Xiaoming Zhang, Yangang Sun, Yuanlin Song, Xiao Su   +16 more
wiley   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

A comprehensive microarray-based DNA methylation study of 367 hematological neoplasms [PDF]

, 2011
Background: Alterations in the DNA methylation pattern are a hallmark of leukemias and lymphomas. However, most epigenetic studies in hematologic neoplasms (HNs) have focused either on the analysis of few candidate genes or many genes and few HN entities,
Agirre, Xabier, Alvarez, Sara, Ammerpohl, Ole, Bibikova, Marina, Brüggemann, Monika, Bug, Stefanie, Calasanz, Maria J., Cruz Cigudosa, Juan, Deckert, Martina, Dreyling, Martin, Du, Ming Q., Dyer, Martin J. S., Dürig, Jan, Fan, Jian-Bing, Gesk, Stefan, Haferlach, Claudia, Hansmann, Martin-Leo, Harder, Lana, Hartmann, Sylvia, Klapper, Wolfram, Küppers, Ralf, Martin-Subero, Jose Ignacio, Montesinos-Rongen, Manuel, Nagel, Inga, Pott, Christiane, Prosper, Felipe, Richter, Julia, Román-Gómez, José, Seifert, Marc, Siebert, Reiner, Stein, Harald, Suela, Javier, Trümper, Lorenz, Vater, Inga, Wickham-Garcia, Eliza   +34 more
core  

Retreatment with R-CHOP–like therapy in patients with late relapse of diffuse large B-cell lymphoma

Blood Advances
: Patients with diffuse large B-cell lymphoma (DLBCL) with late relapse (>2 years from diagnosis) may be treated with a second course of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone)–like therapy particularly if ...
Jean-Nicolas Champagne, Diego Villa, Alina S. Gerrie, Christopher P. Venner, Graham W. Slack, Pedro Farinha, Jeffrey W. Craig, Laura K. Hilton, Kerry J. Savage, David W. Scott, Laurie H. Sehn   +10 more
doaj   +1 more source

Stochastic Nanoscale Biophysical Cues as a Basis for the Induction of Glioblastoma‐Like Transcriptional Programs in Astrocytes

Advanced Science, EarlyView.
Stochastic nanoscale physical cues induce glioblastoma (GBM)‐associated transcriptional traits in naïve astrocytes leading to spontaneous formation of spheroids. Cells within spheroids express activated‐MMP2 and a differential gene expression pattern involving P53 and NOTCH3, providing evidence for a role for changes in brain topography, as observed in
Laurent Starck, Tobias Butelmann, Sabrina Hogan, Melika Sarem, Bernd Heimrich, Ritwick Sawarkar, Marie‐Françoise Ritz, Gregor Hutter, V. Prasad Shastri   +8 more
wiley   +1 more source