Results 181 to 190 of about 745,482 (386)

rWTC‐MBTA Vaccine, Alone and Enhanced with Anti‐PD1, Elicits Immune Responses against CNS and Peripheral B‐Cell Lymphoma

Advanced Science, EarlyView.
An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang, Juan Ye, Mitchell Sun, Samik Chakraborty, Alex Valenzuela, Shuran Chen, Qingfeng Xue, Wenyu Shi, Karel Pacak, Herui Wang, Zhengping Zhuang   +10 more
wiley   +1 more source

Concurrent Composite Lymphomas Collectively Bearing Three Diagnostic Entities of Shared Clonal Origin

HemaSphere, 2022
Waleed Alduaij, Laura K. Hilton, Muntadhar Al Moosawi, Susana Ben-Neriah, Barbara Meissner, Merrill Boyle, Kelly Mekwunye, David W. Scott, Heather A. Leitch, Jeffrey W. Craig   +9 more
doaj   +1 more source

Dysregulation of Innate Lymphoid Cells in Common Variable Immunodeficiency

, 2017
Paul J. Maglione, Montserrat Cols, Charlotte Cunningham‐Rundles   +2 more
openalex   +2 more sources

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses

Advanced Science, EarlyView.
Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng, Jing Sun, Chun Lu, Qian Yu, Yiyun He, Bingqing Wu, Deshan Ren, Shuai Ding, Jincun Zhao, Yan Li   +9 more
wiley   +1 more source

A spheroid model that recapitulates the protective role of the lymph node microenvironment and serves as a platform for drug testing in chronic lymphocytic leukemia

HemaSphere
Chronic lymphocytic leukemia (CLL) B cells are characterized by a propensity to undergo rapid apoptosis when cultured in vitro, underscoring the importance of the tissue microenvironment for disease survival.
Elisa Lenti, Edoardo Visentin, Engin Bojnik, Alessia Neroni, Martina Franchino, Daniela Talarico, Nicolò Sacchetti, Lydia Scarfò, Aurora Maurizio, Jose Manuel Garcia‐Manteiga, Paolo Ghia, Andrea Brendolan   +11 more
doaj   +1 more source

Identification of an N-acetylglucosamine-6-O-sulfotransferase activity specific to lymphoid tissue: an enzyme with a possible role in lymphocyte homing

, 1998
Kendra G. Bowman, Stefan Hemmerich, Sunil Bhakta, Mark S. Singer, Annette Bistrup, Steven D. Rosen, Carolyn R. Bertozzi   +6 more
openalex   +1 more source

Innate Lymphoid Cells: 10 Years On

Cell, 2018
É. Vivier, D. Artis, M. Colonna, A. Diefenbach, J. D. Santo, G. Eberl, S. Koyasu, R. Locksley, A. McKenzie, R. Mebius, F. Powrie, H. Spits   +11 more
semanticscholar   +1 more source

A Microbiota‐ and IL‐15‐Dependent Innate‐Like B Cell Progenitor Expressing E4BP4

Advanced Science, EarlyView.
This work identifies CD3.NKp46.CD19.NK1.1. NK‐B cells enriched in PDK1‐deficient yet present in wild‐type bone marrow. IL‐15 (via CD122) and TLR9‐microbiota signaling maintain their E4BP4 expression. These cells demonstrate innate immunity, preferentially differentiate into B cells, and unveil a novel microbiota‐ and IL‐15‐dependent regulatory pathway ...
Junming He, Xinlei Hou, Xiaomei Feng, Yayun Dong, Mengqi Ren, Surong Deng, Xinru Yang, Donglin Chen, Lingna Zhao, Shasha Chen, Meixiang Yang, Zhongjun Dong   +11 more
wiley   +1 more source

Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia.

New England Journal of Medicine, 2011
D. Porter, B. Levine, M. Kalos, A. Bagg, C. June   +4 more
semanticscholar   +1 more source

Extracellular Vesicles of Streptococcus anginosus Mediate Gastritis via Epithelial Barrier Disruption and Macrophage‐driven Inflammation

Advanced Science, EarlyView.
Streptococcus anginosus extracellular vesicles (SA‐EVs) accumulate in gastric tissue, disrupt epithelial tight junctions, and induce gastritis characterized by neutrophil infiltration and elevated cytokines (TNF‐α, IL‐6, IL‐17A). Proteomics identifies TMPC and FBP62 as key SA‐EVs virulence factors; their genetic deletion attenuates inflammation ...
Ying Gong, Lina Duan, Jie Xiao, Yulu Deng, Hongxia Wang, Yajie Zhang, Xiumei Hu, Haifang Wang, Taixue An, Xin Li, Yurong Qiu, Lei Zheng, Haixia Li   +12 more
wiley   +1 more source