Results 121 to 130 of about 17,698,083 (199)

Proteomic Profiling of Nodal T‐Follicular Helper Cell Lymphoma Reveals Distinct Biological Signatures and Improves Prognostic Stratification Beyond the IPI

American Journal of Hematology, EarlyView.
ABSTRACT Nodal T‐follicular helper cell lymphoma (nTFHL), most commonly of angioimmunoblastic type, exhibits heterogeneous clinical outcomes that are not fully explained by current clinical and biological variables. While genetic alterations have been extensively investigated, its proteomic landscape remains largely unexplored.
David Beauvais, Yanis Zirem, Tristan Cardon, Soulaimane Aboulouard, Romain Dubois, Isabelle Fournier, Franck Morschhauser, Michel Salzet, Ibrahim Yakoub‐Agha, Marie Duhamel   +9 more
wiley   +1 more source

Final Analysis of the BRUIN Phase 1/2 Study Assessing the Safety and Efficacy of Pirtobrutinib Monotherapy in Patients With MCL

American Journal of Hematology, EarlyView.
ABSTRACT Pirtobrutinib, a highly selective, non‐covalent Bruton tyrosine kinase inhibitor (BTKi) previously demonstrated durable efficacy and tolerable safety following covalent (c) BTKi therapy in heavily pretreated relapsed/refractory (R/R) mantle cell lymphoma (MCL).
Michael L. Wang, Jonathon B. Cohen, Nirav N. Shah, Wojciech Jurczak, Pier Luigi Zinzani, Chan Y. Cheah, Chaitra S. Ujjani, Youngil Koh, Won Seog Kim, Sunita D. Nasta, Ian Flinn, Benoit Tessoulin, Shuo Ma, Alvaro J. Alencar, David J. Lewis, Jennifer A. Woyach, Kami J. Maddocks, Krish Patel, Yucai Wang, Joanna M. Rhodes, Constantine S. Tam, John F. Seymour, Hirokazu Nagai, Julie M. Vose, Bita Fakhri, Marc S. Hoffmann, Francisco Hernandez‐Ilizaliturri, Andrew D. Zelenetz, Anita Kumar, Talha Munir, Donald E. Tsai, Paolo Abada, Minna Balbas, Jian Li, Denise Wang, Lindsey E. Roeker, Toby A. Eyre   +36 more
wiley   +1 more source

Precision Matters: Minor Concentration Deviations of DMSO May Cause Major Efficacy Shifts

Angewandte Chemie, EarlyView.
Low‐concentration dimethyl sulfoxide (DMSO) has long been regarded as biologically safe in drug discovery. However, increasing DMSO from 0.1% to 0.9% reduces photosensitizer PNA‐9 particle size from 657 nm to 260 nm, enhancing endocytosis and photodynamic therapy outcomes.
Sisi Yuan, Shang Zhu, Hang Song, Fei Wang, Zikai He, Sijie Chen, Engui Zhao   +6 more
wiley   +2 more sources

Concurrent Germline RB1 & Mosaic TP53 in a Child With Multiple Childhood Cancers

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT We report a patient with a pathogenic germline variant (PGV) in RB1 and somatic mosaicism for a pathogenic TP53 variant who developed three distinct types of childhood cancer: retinoblastoma, osteosarcoma, and myelodysplastic syndrome (MDS) before the age of 6 years.
Ole Haubjerg Nielsen, Ulrik Kristoffer Stoltze, Pernille Axél Gregersen, Marianne Hoffmann, Morten Lyng Høgild, Mette Klarskov Andersen, Lise Barlebo Ahlborn, Lisa Lyngsie Hjalgrim, Karin A. W. Wadt   +8 more
wiley   +1 more source

A DNA G‐Quadruplex‐Targeting Ligand Suppresses c‐MYC Expression: Implications for Gemcitabine‑Resistant Pancreatic Cancer

Angewandte Chemie, EarlyView.
PQB‐4, a fluorescent small‐molecule ligand that targets c‐MYC DNA G‐quadruplexes (G4s), showed marked synergy with gemcitabine in resistant PANC‐1 cells (CI = 0.027). In vivo, the ligand reduced tumor weight by 44% in a PANC‐1 xenograft model. These results highlight the therapeutic potential of c‐MYC DNA G4‐targeting ligands for treating gemcitabine ...
Bo‐Xin Zheng, Ya‐Kun Wang, Ze‐Xin Chen, Yi‐Wen Meng, Meng‐Ting She, Jia‐Peng Dong, Yingying Zheng, Yao‐Xun Zeng, Wen‐De Zheng, Wei Long, Wing‐Leung Wong   +10 more
wiley   +2 more sources

PRDM1/BLIMP-1 expression in multiple B and T-cell lymphoma

Haematologica, 2006
BACKGROUND AND OBJECTIVES: The positive regulatory domain I (PRDM1) protein or BLIMP-1, belonging to the PRDM gene family of transcriptional repressors, is a key regulator of terminal differentiation in B-lymphocytes and is critical for plasma cell ...
JF Garcia, G Roncador, JF Garcia, AI Sanz, L Maestre, E Lucas, S Montes-Moreno, R Fernandez Victoria, JL Martinez-Torrecuadrara, T Marafioti, DY Mason, MA Piris   +11 more
doaj  

Atypical X‐Linked Severe Combined Immunodeficiency in a Patient With Early‐Onset Inflammatory Bowel Disease

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Primary immunodeficiency disorders may present with gastrointestinal inflammation resembling inflammatory bowel disease (IBD), particularly in patients with pediatric or very‐early‐onset disease. We report a 24‐year‐old male with lifelong immune dysregulation and early‐onset IBD who was ultimately found to carry a hemizygous intronic IL2RG ...
Agustina Fainguersch, Jennah Foltz, Theodore E. Wilson, Sydney A. Lau, Xiaonan Zhao, Casey A. Thornton, Morgan Driver, Jay Jun‐Hong Jin, Jean P. Molleston, Xiaoyi Zhang   +9 more
wiley   +1 more source

Nasal Tuft Cell Markers Are Predictive of Overall Survival in Sinonasal Neuroendocrine and Sinonasal Undifferentiated Carcinomas

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Sinonasal neuroendocrine carcinoma (SNEC) and sinonasal undifferentiated carcinoma (SNUC) are rare aggressive malignancies with no established prognostic markers. Because features of POU2F3+ small cell lung carcinomas have been identified in both tumors, we evaluated immunostaining for POU2F3, a tuft cell transcription factor, and ...
Nikolina Dioufa, Ricardo V. Bruneto, Jennifer E. Douglas, Nithin D. Adappa, James N. Palmer, Noam A. Cohen, Michael A. Kohanski   +6 more
wiley   +1 more source

Adhesion molecule profiles of B-cell non-Hodgkin's lymphomas in the leukemic phase

Brazilian Journal of Medical and Biological Research, 2006
We evaluated the expression of 10 adhesion molecules on peripheral blood tumor cells of 17 patients with chronic lymphocytic leukemia, 17 with mantle-cell lymphoma, and 13 with nodal or splenic marginal B-cell lymphoma, all in the leukemic phase and ...
D.M. Matos, E.G. Rizzatti, A.B. Garcia, D.A.P. Gallo, R.P. Falcão   +4 more
doaj  

A B-cell lymphoma case that is unclassifiable, and intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma of lacrimal gland

, 2017
Tatsuya Yunoki,1 Jun Murakami,2 Yukihiro Imagawa,3 Takahiko Nakajima,4 Atsushi Hayashi1 1Department of Ophthalmology, 2Department of Gastroenterology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, 3Department of ...
Murakami J, Nakajima T, Yunoki T, Hayashi A, Imagawa Y   +4 more
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