Results 111 to 120 of about 244,635 (318)

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source

Clinicopathological features of extranodal lymphomas: Kuwait experience [PDF]

, 2004
A total of 935 patients with extranodal non-Hodgkin lymphoma (NHL) diagnosed in the period between January 1985 and December 2000 in Kuwait Cancer Center, serving the whole population of Kuwait, were used to describe the clinicopathological and ...
Bamanikar S, D'Amore F, Ducreux M, F. Sinowatz, Freeman C, Gospodarowicz MK, H. Amanguno, H. Baker, Hauke RJ, J.P. Madda, L. Temmim, Longo DL, Neugut AI, Penn I, Shome DK, Stiller CA, Weisenburger DD, Zeeb H   +17 more
core   +1 more source

Prognostic Significance of MYC Rearrangement and Translocation Partner in Diffuse Large B-Cell Lymphoma: A Study by the Lunenburg Lymphoma Biomarker Consortium.

Journal of Clinical Oncology, 2019
PURPOSE MYC rearrangement (MYC-R) occurs in approximately 10% of diffuse large B-cell lymphomas (DLBCLs) and has been associated with poor prognosis in many studies.
A. Rosenwald, S. Bens, R. Advani, S. Barrans, C. Copie-Bergman, M-H. Elsensohn, Y. Natkunam, M. Calaminici, B. Sander, M. Baia, Alexandra G. Smith, D. Painter, Luu Q. Pham, Shuchun Zhao, M. Ziepert, Ekaterina Jordanova, T. Molina, M. Kersten, E. Kimby, W. Klapper, J. Raemaekers, N. Schmitz, F. Jardin, W. Stevens, E. Hoster, A. Hagenbeek, J. Gribben, R. Siebert, R. Gascoyne, D. Scott, P. Gaulard, G. Salles, C. Burton, D. de Jong, L. Sehn, D. Maucort-Boulch   +35 more
semanticscholar   +1 more source

Targeting DAP5 Disrupts Alternate Mode of Translational Initiation in Tregs and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
Regulatory T cells (Tregs) suppress antitumor immunity. This study identifies that the translation scaffold DAP5/eIF4G2 is upregulated in tumor‐infiltrating Tregs (ti‐Tregs). DAP5 mediates an alternate translation mode to sustain CD25 and MCL‐1 expression, which is critical for ti‐Treg stability and survival in the tumor microenvironment.
Xiaojiang Lai, Guihong Pan, Xixi Feng, Jun Zhang, Yunxia Li, Shanmeizi Zhao, Zhenming Lin, Yun Feng, Wei Bao, Hongyan Yang, Chengmei Xie, Chen Huang, Jun Wang   +12 more
wiley   +1 more source

Central nervous system lymphomas: a histologic and immunophenotypic analysis [PDF]

, 2000
Objective: To observe the spectrum of non-Hodkin’s lymphomas involving the central nervous system including morphological subtypes and immunophenotypic status.
lmran Siddiqui, lmran Siddiqui, Muzaffar, Suhail, Naila Kayani, Naila Kayani, Pervez, Shahid, Sheema H. Hasan, Sheema H. Hasan Sheema H. Hasan, Siddiqui, M. Shahid, Soomro, Irshad Nabi   +6 more
core   +1 more source

Case Report: PTHrP Related Hypercalcemia in Diffuse Large B-cell Lymphoma [PDF]

, 2016
INTRODUCTION Hypercalcemia is commonly associated with solid tumor malignancies, but less often with hematologic malignancies. When present in hematologic malignancies, hypercalcemia is often secondary to overproduction of Vitamin D from the tumor cells.
Caruso, MD, Evan, Mehta, MD, Ankita
core   +2 more sources

International prognostic indices in diffuse large B-cell lymphoma (DLBCL): a comparison of IPI, R-IPI and NCCN-IPI.

Blood, 2020
Great heterogeneity in survival exists for patients newly diagnosed with DLBCL. Three scoring systems incorporating simple clinical parameters (age, lactate dehydrogenase, number/sites of involvement, stage, performance status) are widely used: the ...
A. Ruppert, J. G. Dixon, G. Salles, A. Wall, D. Cunningham, V. Poeschel, C. Haioun, H. Tilly, H. Ghesquières, M. Ziepert, J. Flament, C. Flowers, Q. Shi, N. Schmitz   +13 more
semanticscholar   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Diffuse Large B-cell Lymphoma in Patient after Treatment of angioimmunoblastic T-cell Lymphoma [PDF]

, 2010
Relatively few cases of Epstein-Barr (EBV)-positive B-cell lymphomas arising in patients with angioimmunoblastic T-cell lymphoma (AITL) have been reported.
Branimir Jakšić, Delfa Radić-Krišto, Ika Kardum-Skelin, Nives Džeko Škugor, Radovan Vrhovac, Zinaida Perić   +5 more
core   +1 more source

Population-based study of autoimmune conditions and the risk of specific lymphoid malignancies [PDF]

, 2009
Some autoimmune conditions are associated with increased risk of lymphoid malignancies, but information on specific malignancy subtypes is limited. From the U.S.
Anderson, Lesley, Berndt, S.I., Engels, E.A., Gadalla, S., Landgren, O., Morton, L.M., Parsons, R., Pfeiffer, R., Ricker, W., Warren, J.L.   +9 more
core   +1 more source