Results 171 to 180 of about 24,145,261 (292)

Anaplastic lymphoma kinase (ALK) positive diffuse large B cell lymphoma in a 20 year old: A rare entity

open access: yes, 2014
Anaplastic lymphoma kinase (ALK) positive diffuse large B cell lymphoma in a 20 year old: A rare ...
R Sachdev (13310379)   +3 more
core  

Bruton tyrosine kinase inhibitors and cardiovascular adverse events

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Bruton tyrosine kinase inhibitors (BTKi) have transformed the management of chronic lymphocytic leukaemia and other B‐cell malignancies, yet their therapeutic benefit is tempered by clinically relevant cardiovascular toxicities (predominantly atrial fibrillation, hypertension, bleeding and ventricular arrhythmias).
Massimiliano Camilli   +4 more
wiley   +1 more source

An inhibitor of the mitochondrial respiratory chain exerts synergistic anti‐tumour effects when combined with alkylating agents

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Cancer cells exhibit the Warburg effect, but oxidative phosphorylation (OXPHOS) is also important for cancer cell proliferation. Metabolic reprogramming from glycolysis to OXPHOS is one mechanism of resistance to anti‐tumour drugs.
Emiri Omori Takaki   +7 more
wiley   +1 more source

SLAMF6 Enhances the Efficacy of Anti‐PD‐L1 Immunotherapy in CRC Through the STAT1/CXCL10 Signaling Axis

open access: yesCancer Science, EarlyView.
SLAMF6 recruits SHP‐2 to activate STAT1, upregulates CXCL10 and PD‐L1, promotes CD8+T cell infiltration, and enhances the efficacy of anti‐PD‐L1 therapy. ABSTRACT As a T‐cell receptor co‐stimulatory protein, signaling lymphocyte activation molecule family 6 (SLAMF6) is a member of the immune cell activating receptor family and is expressed on T cells ...
Yu Wu   +8 more
wiley   +1 more source

Immune Background Profiles Across B-cell Lymphoproliferative Disorders. [PDF]

open access: yesCureus
Balasuriya T   +5 more
europepmc   +1 more source

Independent validation of the International Metabolic Prognostic Index (CAR‐IMPI) in patients with aggressive diffuse large B‐cell lymphoma treated with CAR‐T

open access: yes
British Journal of Haematology, EarlyView.
Eugenio Galli   +11 more
wiley   +1 more source

High ZFP36 Family Expression in Exhausted T Cells Is Associated With Impaired Antitumor Effector Function

open access: yesCancer Science, EarlyView.
Hypoxia induces ZFP36 family expression in exhausted CD8+ T cells, promoting the decay of AU‐rich effector cytokine mRNAs and suppressing TNF, IL2, and IFNG expression, thereby potentially contributing to impaired antitumor effector function. ABSTRACT Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment by reinvigorating antitumor ...
Li Zhu   +12 more
wiley   +1 more source

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