Results 131 to 140 of about 24,145,261 (292)

An Analysis of CT‐Guided Percutaneous Core Needle Biopsy of Tibial Lesions: How Successful Are We?

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background and Objectives Core needle biopsy (CNB) is commonly used to diagnose bone tumors, but characteristics of tibial lesions may affect its diagnostic performance. We evaluated the diagnostic performance of CT‐guided CNB for tibial lesions, factors associated with diagnostic success, and outcomes of nondiagnostic biopsies.
Lauren E. Wessel, Mikayla R. Mefford, Durga Ghosh, Scott D. Nelson, Alexander B. Christ, Michael Russell, Nicholas M. Bernthal, Joseph K. Kendal   +7 more
wiley   +1 more source

Nail Disorders in Systemic Conditions

JEADV Clinical Practice, EarlyView.
ABSTRACT Nail findings in children can be indicative of an underlying systemic disease. Many of these findings are seen in multiple entities and are not specific to one disease. The importance of specifically examining for these nail changes cannot be overstated.
Jane Sanders Bellet
wiley   +1 more source

PRDM1/BLIMP-1 expression in multiple B and T-cell lymphoma

Haematologica, 2006
BACKGROUND AND OBJECTIVES: The positive regulatory domain I (PRDM1) protein or BLIMP-1, belonging to the PRDM gene family of transcriptional repressors, is a key regulator of terminal differentiation in B-lymphocytes and is critical for plasma cell ...
JF Garcia, G Roncador, JF Garcia, AI Sanz, L Maestre, E Lucas, S Montes-Moreno, R Fernandez Victoria, JL Martinez-Torrecuadrara, T Marafioti, DY Mason, MA Piris   +11 more
doaj  

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág, Krisztián Márk Karvaly, Alexandra Molnár, Mirjam Balbisi, Júlia Németh, Lilla Turiák   +5 more
wiley   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Identification of novel targets for immunotherapies in subsets of patients with diffuse large B-cell lymphoma (DLBCL). [PDF]

Personalized treatment options for subsets of patients with DLBCL are beginning to emerge. Caracciolo et al. explore UMG1, an epitope of CD43 as a potential target for certain patients with DLBCL, and demonstrate promising preclinical activity of an Anti-
Pabst, Thomas, Heini, Alexander D, Bacher, Ulrike   +2 more
core   +1 more source

Prime editing in neuropsychiatric disorders: From mutation‐specific target selection to clinical translation

Neuroprotection, EarlyView.
Abstract Prime editing, a novel clustered regularly interspaced short palindromic repeats (CRISPR)‐based technology, fuses a reverse transcriptase (RT) to an engineered CRISPR‐associated protein 9 (Cas9) and uses a prime editing guide RNA (pegRNA)‐encoded template.
Tianshan Ji, Yuan Zhang, Jinyi Zhao, Yiping Lu, Chengkun Wang   +4 more
wiley   +1 more source

Long‐term outcomes of haploidentical hematopoietic stem cell transplantation with antithymocyte globulin–based myeloablative conditioning in pediatric refractory or relapsed non‐Hodgkin lymphoma

Pediatric Investigation, EarlyView.
Single‐center retrospective data showed that ATG‐based myeloablative haploidentical hematopoietic stem cell transplantation provides durable remission and favorable long‐term survival in children with refractory/relapsed non‐Hodgkin lymphoma, achieving high engraftment rates, low relapse incidence, and acceptable toxicity.
Chenguang Jia, Jie Zheng, Meng Yuan, Hongbo He, Yibo Fan, Bin Wang, Guanghua Zhu, Jun Yang, Yanhui Luo, Lixiao Cai, Pan Zhang, Yanlong Duan, Maoquan Qin   +12 more
wiley   +1 more source

From prediction to intervention: Causal artificial intelligence as the missing link in precision therapeutics

Precision Medical Sciences, EarlyView.
Predictive multiomics artificial intelligence (AI) identifies risk but does not indicate which intervention will change a patient's outcome; causal AI, anchored in biological mechanism, bridges this gap to enable individualized treatment decisions.
Gedion Mengistu Dejen
wiley   +1 more source

Designed Peptide Coacervates for Extracellular Antibody Targeting

Small, EarlyView.
Peptide‐based coacervates formed by liquid‐liquid phase separation provide a membraneless platform for therapeutic antibody delivery. Using Rituximab as a model, these coacervates enable efficient encapsulation, enhanced cell interactions, and provide partial protection from enzymatic proteolysis while maintaining low cytotoxicity.
Nofar Berman, Omer Grotto, Limor Nahary, Itai Benhar, Ayala Lampel   +4 more
wiley   +1 more source