Results 171 to 180 of about 244,635 (318)

Machine Learning for Predictive Modeling in Nanomedicine‐Based Cancer Drug Delivery

Med Research, EarlyView.
The integration of AI/ML into nanomedicine offers a transformative approach to therapeutic design and optimization. Unlike conventional empirical methods, AI/ML models (such as classification, regression, and neural networks) enable the analysis of complex clinical and formulation datasets to predict optimal nanoparticle characteristics and therapeutic
Rohan Chand Sahu, Sanchit Arora, Dinesh Kumar, Ashish Kumar Agrawal   +3 more
wiley   +1 more source

Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes

Nature Medicine, 2018
B. Chapuy, C. Stewart, Andrew J. Dunford, Jaegil Kim, A. Kamburov, R. Redd, Mike S. Lawrence, M. Roemer, Amy Li, M. Ziepert, A. Staiger, J. Wala, M. Ducar, I. Leshchiner, Ester Rheinbay, A. Taylor-Weiner, C. Coughlin, J. Hess, C. Pedamallu, D. Livitz, D. Rosebrock, Mara W Rosenberg, A. Tracy, H. Horn, P. Van Hummelen, A. Feldman, B. Link, A. Novak, J. Cerhan, T. Habermann, R. Siebert, A. Rosenwald, A. Thorner, M. Meyerson, T. Golub, R. Beroukhim, G. Wulf, G. Ott, S. Rodig, S. Monti, D. Neuberg, M. Loeffler, M. Pfreundschuh, L. Trümper, G. Getz, M. Shipp   +45 more
semanticscholar   +1 more source

Loss‐of‐Function Variants in CPT1C: No Support for a Causal Role in Hereditary Spastic Paraplegia

Movement Disorders, EarlyView.
Abstract Background Hereditary spastic paraplegias (HSPs) are neurodegenerative disorders characterized by lower‐limb spasticity. Pathogenic variants in CPT1C have been implicated in HSP. Objective The objective of this study was to assess whether CPT1C loss‐of‐function (LOF) variants are causally associated with HSP.
Rui Zhu, Lang Liu, Mehrdad A. Estiar, Farnaz Asayesh, Jamil Ahmad, Meron Teferra, Grace Yoon, Mark Tarnopolsky, Kym M. Boycott, Nicolas Dupre, Patrick A. Dion, Oksana Suchowersky, Albena Jordanova, Yi‐Chung Lee, Giovanni Stevanin, Stephan Zuchner, Guy A. Rouleau, Ziv Gan‐Or   +17 more
wiley   +1 more source

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, EarlyView.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

BRIDGING TO TRANSPLANT IN DIFFUSE LARGE B CELL LYMPHOMA

European Medical Journal Hematology, 2016
Non-Hodgkin lymphoma (NHL) is the eighth most common malignancy worldwide. Diffuse large B cell lymphoma (DLBCL) is the most frequent subtype, accounting for >30% of NHL cases.
Christian Gisselbrecht, Eric Van Den Neste   +1 more
doaj  

Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto, Samaneh Ghadami, Kristen Dellinger   +2 more
wiley   +1 more source

Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma

Nature, 2010
R. Davis, V. Ngo, G. Lenz, P. Tolar, R. Young, Paul B. Romesser, H. Kohlhammer, L. Lamy, Hong Zhao, Yandan Yang, Weihong Xu, A. Shaffer, George W. Wright, Wenming Xiao, J. Powell, Jian-Kang Jiang, Craig J. Thomas, A. Rosenwald, G. Ott, H. Müller-hermelink, R. Gascoyne, J. Connors, N. Johnson, L. Rimsza, E. Campo, E. Jaffe, W. Wilson, J. Delabie, E. Smeland, R. Fisher, R. Braziel, R. Tubbs, J. Cook, D. Weisenburger, W. C. Chan, S. Pierce, L. Staudt   +36 more
semanticscholar   +1 more source

Advances in Elemene Nanodelivery Systems: From Material Design to Disease Treatment

Rare Metals, EarlyView.
ABSTRACT Elemene (ELE) is a bioactive sesquiterpenoid extracted from traditional Chinese herbs, demonstrating broad‐spectrum antitumor, anti‐inflammatory, and analgesic properties with significant therapeutic potential. However, its clinical utility is constrained by inherent physicochemical limitations, including volatility and hydrophobicity, which ...
Xiao Wang, Jiatong Lin, Yi Peng, Zehua Wu, Yingying Liu, Wei Duan, Qiaolin Wei, Jia‐Wei Shen, Jiang‐Xing Chen, Yong Guo   +9 more
wiley   +1 more source

Blue‐Gray Papules on the Chest and Face

JEADV Clinical Practice, EarlyView.
Sanjana Likki, Kevin Lee, Priyadharsini Nagarajan, Doina Ivan, Woo Cheal Cho, Fiorinda Muhaj   +5 more
wiley   +1 more source

Review on enhancing clinical decision support system using machine learning

CAAI Transactions on Intelligence Technology, EarlyView.
Abstract Clinical decision‐making is a complex patient‐centred process. For an informed clinical decision, the input data is very thorough ranging from detailed family history, environmental history, social history, health‐risk assessments, and prior relevant medical cases.
Anum Masood, Usman Naseem, Junaid Rashid, Jungeun Kim, Imran Razzak   +4 more
wiley   +1 more source