Results 51 to 60 of about 244,635 (318)

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

The small FOXP1 isoform predominantly expressed in activated B cell-like diffuse large B-cell lymphoma and full-length FOXP1 exert similar oncogenic and transcriptional activity in human B cells

Haematologica, 2017
The forkhead transcription factor FOXP1 is generally regarded as an oncogene in activated B cell-like diffuse large B-cell lymphoma. Previous studies have suggested that a small isoform of FOXP1 rather than full-length FOXP1, may possess this oncogenic ...
Martine van Keimpema, Leonie J. Grüneberg, Esther J.M. Schilder-Tol, Monique E.C.M. Oud, Esther A. Beuling, Paul J. Hensbergen, Johann de Jong, Steven T. Pals, Marcel Spaargaren   +8 more
doaj   +1 more source

Diffuse large B-cell lymphoma with uncommon cardiac invasion

SAGE Open Medical Case Reports, 2022
Diffuse large B-cell lymphoma is the most common histologic subtype of non-Hodgkin lymphoma. Secondary involvement of the heart is seen late in advanced cases, it is uncommon for diffuse large B-cell lymphoma to present as intracardiac mass.
Yunis Daralammouri, Hamza Hamayel, Yahya Ismail, Sajed Majadla, Razan Odeh   +4 more
doaj   +1 more source

Derepressing of STAT3 and USP7 contributes to resistance of DLBCL to EZH2 inhibition

Heliyon, 2023
Diffuse large B-cell lymphoma is the most common subtype of lymphoma, representing ∼25 % of non-Hodgkin lymphoid malignancies. EZH2 is highly expressed in Diffuse large B-cell lymphoma and ∼22 % of patients contain EZH2 mutations.
Chenyun He, Wenbin Zhou, Xiaoxia Jin, Haining Zhou   +3 more
doaj   +1 more source

EBV‐positive diffuse large B‐cell lymphoma, not otherwise specified: 2022 update on diagnosis, risk‐stratification, and management

American journal of hematology/oncology, 2022
Epstein Barr virus‐positive (EBV+) diffuse large B‐cell lymphoma (DLBCL), not otherwise specified (NOS) is an entity included in the WHO classification of lymphoid neoplasms since 2016.
L. Malpica, Mario L. Marques-Piubelli, B. Beltrán, J. Chavez, R. Miranda, J. Castillo   +5 more
semanticscholar   +1 more source

Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro, Issam Tout, Stéphanie Narguet, Cheikh Mohamed Bed, Morgane Roinard, Ahmad Sleiman, Nathalie Boyer, Nathalie Pons‐Kerjean, Corinne Castelnau, Nathalie Giuly, Dorothy Tonui, Vassili Soumelis, Jamel El Benna, Patrick Soussan, Richard Moreau, Valérie Paradis, Abdellah Mansouri, Tarik Asselah   +17 more
wiley   +1 more source

Lymphome intravasculaire : à propos de deux observations autopsiques et revue de la littérature [PDF]

, 2011
Intravacular large B-cell lymphoma (LIV) is a rare entity individualized in the WHO classification since 2001 as a subtype of extranodal diffuse large B-cell lymphoma.
C. Rousselot-Denis, F. Arbion, M. Jaunas, M.C. Rousselet, S. Guyetant   +4 more
core   +2 more sources

Overexpression of FoxM1 offers a promising therapeutic target in diffuse large B-cell lymphoma

Haematologica, 2012
Background FoxM1 has been shown to play a critical role in the pathogenesis of various epithelial malignancies. However, its role in lymphoid malignancies has not been fully clarified.
Shahab Uddin, Azhar R Hussain, Maqbool Ahmed, Khawar Siddiqui, Fouad Al-Dayel, Prashant Bavi, Khawla S. Al-Kuraya   +6 more
doaj   +1 more source

Глобализация как фактор радикализации трансформации приоритетов социально-экономического развития в посттранзитивних экономиках [PDF]

, 2011
Expression of the for khead transcription factor FOXP1 is essential for early B-cell development, whereas down regulation ofFOXP1at the germinal center (GC) stage is required for GC B-cell function. Aberrantly high FOXP1 expression is frequently observed
Banham, Basso, Bende, Bende, Berkowska, Berkowska, Ding, Dogan, Engels, Fenton, Fornek, Goldstein, Gutiérrez, Hans, Horikawa, Hu, Iida, Iqbal, Klein, Kocemba, Kometani, Kuo, Kwon, Lenz, Lenz, Leonie J. Grüneberg, Lin, Liu, Mandelbaum, Marcel Spaargaren, Martin, Martine van Keimpema, McHeyzer-Williams, Menno C. van Zelm, Michal Mokry, Nera, Nutt, Ochiai, Pape, Paul Coffer, Rampanelli, Ruben van Boxtel, Rui, Sagaert, Sagardoy, Scheeren, Schmidlin, Sciammas, Seifert, Shaffer, Shaffer, Shaffer, Shaffer, Shapiro-Shelef, Staudt, Steven T. Pals, Streubel, Taylor, Tunyaplin, van Boxtel, van Keimpema, Vegliante, Yoshida, Zuccarino-Catania   +63 more
core   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source