Results 81 to 90 of about 244,635 (318)

Burkitt-like lymphoma with 11q aberration: a germinal center-derived lymphoma genetically unrelated to Burkitt lymphoma

Haematologica, 2019
Burkitt-like lymphoma with 11q aberration is characterized by pathological features and gene expression profile resembling those of Burkitt lymphoma but lacks the MYC rearrangement and carries an 11q-arm aberration with proximal gains and telomeric ...
Blanca Gonzalez-Farre, Joan Enric Ramis-Zaldivar, Julia Salmeron-Villalobos, Olga Balagué, Verónica Celis, Jaime Verdu-Amoros, Ferran Nadeu, Constantino Sábado, Antonio Ferrández, Marta Garrido, Federico García-Bragado, María Dolores de la Maya, José Manuel Vagace, Carlos Manuel Panizo, Itziar Astigarraga, Mara Andrés, Elaine S. Jaffe, Elias Campo, Itziar Salaverria   +18 more
doaj   +1 more source

Durable remission in a patient with leptomeningeal relapse of a MYC/BCL6-positive double-hit DLBCL treated with lenalidomide monotherapy [PDF]

, 2016
Secondary central nervous system involvement is an uncommon event that typically occurs early in the natural history of diffuse large B-cell lymphoma and presents as leptomeningeal dissemination in two-thirds of cases.
BETTELLI, Stefania Raffaella, LUMINARI, Stefano, MAIORANA, Antonino, Salati, Massimiliano, Tarantino, Vittoria   +4 more
core   +2 more sources

Double-Hit Gene Expression Signature Defines a Distinct Subgroup of Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma.

Journal of Clinical Oncology, 2019
PURPOSE High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements (HGBL-DH/TH) has a poor outcome after standard chemoimmunotherapy. We sought to understand the biologic underpinnings of HGBL-DH/TH with BCL2 rearrangements (HGBL-DH/TH- BCL2)
Daisuke Ennishi, A. Jiang, M. Boyle, B. Collinge, B. Grande, S. Ben-Neriah, C. Rushton, Jeffrey M. Tang, N. Thomas, G. Slack, P. Farinha, K. Takata, T. Miyata‐Takata, J. Craig, A. Mottok, B. Meissner, Saeed Saberi, Ali Bashashati, D. Villa, K. Savage, L. Sehn, R. Kridel, A. Mungall, M. Marra, Sohrab P. Shah, C. Steidl, J. Connors, R. Gascoyne, Ryan D. Morin, D. Scott   +29 more
semanticscholar   +1 more source

Precise Regulation of Membrane Proteins: From Physical Technology to Biomolecular Strategy

Advanced Science, EarlyView.
This review summarizes the emerging strategies for the precise regulation of membrane proteins using physical stimuli and biomolecule‐based tools. These methods provide new insights into cell regulation and offer promising directions for future disease treatment.
Xiu Zhao, Qingqing Zhou, Mengli Li, Wen Zou, Zhenzhong Zhang, Jinjin Shi, Junjie Liu   +6 more
wiley   +1 more source

rWTC‐MBTA Vaccine, Alone and Enhanced with Anti‐PD1, Elicits Immune Responses against CNS and Peripheral B‐Cell Lymphoma

Advanced Science, EarlyView.
An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang, Juan Ye, Mitchell Sun, Samik Chakraborty, Alex Valenzuela, Shuran Chen, Qingfeng Xue, Wenyu Shi, Karel Pacak, Herui Wang, Zhengping Zhuang   +10 more
wiley   +1 more source

Rituximab-EPOCH, an effective salvage therapy for relapsed, refractory or transformed B-cell lymphomas: results of a phase II study [PDF]

, 2017
Background: Relapsed or refractory diffuse large B-cell and mantle-cell lymphoma have a poor prognosis. The EPOCH regimen and rituximab monotherapy have demonstrated activity as salvage therapies.
Betticher, D. C., Egli, F., Honegger, H. P., Jacky, E., Jermann, M., Jost, L. M., Kroner, Th, Stahel, R. A., Taverna, Ch   +8 more
core  

Regulation of molecular processes in diffuse large b-cell lymphoma [PDF]

, 2013
The molecular understanding of diseases has advanced rapidly due to the use of gene expression profiling. However, these methods have been hampered by the limitation to use frozen tissue specimens.
Högfeldt, Therese
core   +1 more source

WDR5‐H3K4me3 Epigenetic Axis Promotes TRMT6‐Dependent tRNA M1A Modification to Facilitate Triple‐Negative Breast Cancer Progression by Suppressing Ferroptosis

Advanced Science, EarlyView.
Upregulated TRMT6 forms aberrant hypermethylation of a specific tRNA pool and serves as a predictor of poor prognosis in TNBC. This m1A modification in tRNAs enhances translation of FTH1 and FTL, reducing the pool of bioavailable Fe2⁺. Reduced Fe2+ availability impairs RSL3‐induced lipid peroxidation and tumor progression.
Yuqing Lei, Xue Wang, Jiahe Liu, Zixu Niu, Jiaqi Hua, Qian Guo, Dan Du, Yuanchang Zhu, Fucheng He, Mingxia Zhou, Hongle Li, Jing He, Jun Li   +12 more
wiley   +1 more source

Non-Hodgkin and Hodgkin Lymphomas Select for Overexpression of BCLW. [PDF]

, 2017
Purpose: B-cell lymphomas must acquire resistance to apoptosis during their development. We recently discovered BCLW, an antiapoptotic BCL2 family member thought only to contribute to spermatogenesis, was overexpressed in diffuse large B-cell lymphoma ...
Adams, Clare M., Eischen, Christine M., Gong, MD, Jerald Z., Mitra, Ramkrishna   +3 more
core   +1 more source

Non-Hodgkin Lymphoma in Children and Adolescents: Progress Through Effective Collaboration, Current Knowledge, and Challenges Ahead [PDF]

, 2015
Non-Hodgkin lymphoma is the fourth most common malignancy in children, has an even higher incidence in adolescents, and is primarily represented by only a few histologic subtypes. Dramatic progress has been achieved, with survival rates exceeding 80%, in
Auperin, Anne, Brugi\ue8res, Laurence, Burkhardt, Birgit, Cairo, Mitchell S, Damm Welk, Christine, Gross, Thomas G, Horibe, Keizo, Klapper, Wolfram, Lamant, Laurence, Le Deley, Marie C\ue9cile, Macintyre, Elizabeth, Minard Colin, V\ue9ronique, Mussolin, Lara, Patte, Catherine, Perkins, Sherrie L, Pillon, Marta, Poirel, H\ue9l\ue8ne A, Raphael, Martine, Reiter, Alfred, Rosolen, Angelo, Sandlund, John T, Williams, Denise, Woessmann, Wilhelm, Zimmerman, Martin   +23 more
core   +1 more source