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Properties of the mantle cell and mantle cell lymphoma
Current Opinion in Hematology, 2002The major lymphoid inhabitant of the follicular mantle is the mantle cell, an immunologically naïve B cell. It is the putative cell of origin of mantle cell lymphoma (MCL), the cells of which have similar morphologic, immunophenotypic, and molecular characteristics to the normal B lymphocytes of the mantle zone.
John L. Frater, Eric D. Hsi
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Advances in Anatomic Pathology, 1998
Mantle cell lymphomas comprise 2 to 8% of non-Hodgkin's lymphoma in the United States. They occur in older adults with a distinct male predominance, who present with generalized lymphadenopathy, and often have disseminated disease at the time of diagnosis.
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Mantle cell lymphomas comprise 2 to 8% of non-Hodgkin's lymphoma in the United States. They occur in older adults with a distinct male predominance, who present with generalized lymphadenopathy, and often have disseminated disease at the time of diagnosis.
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, 2013 Mantle cell lymphoma (MCL) is a B-cell neoplasm thought to derive from mantle zone B-cells and characterized by translocations involving the CCND1 gene, most commonly t(11;14)(q13;q23). The classical variant of MCL is comprised of small- to medium-sized cells with irregular nuclear contours.
Roberto N. Miranda +2 more
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Mantle Cell Lymphoma: An Update
Leukemia & Lymphoma, 1992Mantle cell lymphoma is a distinctive pathologic entity that incorporates the previous histopathologic categories of centrocytic lymphoma and lymphocytic lymphoma of intermediate differentiation. These lymphomas are characterized by common histologic and immunologic characteristics that suggest derivation from the follicular mantle zone.
Elaine S. Jaffe +3 more
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Clinical Lymphoma Myeloma and Leukemia, 2017
Mr HK is a 67-year-old Caucasian man with a past medical history of hypertension. He presented to his primary care physician’s office in June 2014 with 3 months’ history of fever, fatigue, and an enlarged cervical lymph node.
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Mr HK is a 67-year-old Caucasian man with a past medical history of hypertension. He presented to his primary care physician’s office in June 2014 with 3 months’ history of fever, fatigue, and an enlarged cervical lymph node.
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Lenalidomide for mantle cell lymphoma
Expert Review of Hematology, 2015Mantle cell lymphoma accounts for 6% of all non-Hodgkin lymphomas. It is a biologically and clinically heterogeneous disease and treatment may be difficult, since most patients present at an older age, being unable to undergo intensive chemotherapy. Lenalidomide is an approved medication for relapsed mantle cell lymphoma in patients who received at ...
Alan P Skarbnik, Andre Goy
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2019
Mantle cell lymphoma (MCL) of the ocular adnexa does not differ from systemic mantle cell lymphoma in its biological and clinical behaviour. As the name suggests, it arises from the mantle zone of the lymphoid follicles. It is a mature B-cell lymphoma, which is much less common than the other subtypes of B-cell lymphomas, and has an aggressive clinical
Bingcheng Wu +5 more
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Mantle cell lymphoma (MCL) of the ocular adnexa does not differ from systemic mantle cell lymphoma in its biological and clinical behaviour. As the name suggests, it arises from the mantle zone of the lymphoid follicles. It is a mature B-cell lymphoma, which is much less common than the other subtypes of B-cell lymphomas, and has an aggressive clinical
Bingcheng Wu +5 more
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Mantle-Cell Lymphomas of the Skin
Dermatologic Clinics, 1994The skin lesions of two elderly women lead us to the diagnosis of small cleaved lymphocytic B-cell non-Hodgkin's lymphoma, TNM stage IVb after clinical staging examinations. Relapses occurred within less than 1 year. Morphology, enzymhistochemistry (alkaline phosphatase in the first case), and immunohistochemistry (CD 5 positivity in the second case ...
M.L. Geerts, Anne-Marie Busschots
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