Results 11 to 20 of about 23,301 (197)

SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype

Haematologica, 2009
Background Cyclin D1-negative mantle cell lymphoma is difficult to distinguish from other small B-cell lymphomas. The clinical and pathological characteristics of patients with this form of lymphoma have not been well defined.
Ana Mozos, Cristina Royo, Elena Hartmann, Daphne De Jong, Cristina Baró, Alexandra Valera, Kai Fu, Dennis D. Weisenburger, Jan Delabie, Shih-Sung Chuang, Elaine S. Jaffe, Carmen Ruiz-Marcellan, Sandeep Dave, Lisa Rimsza, Rita Braziel, Randy D. Gascoyne, Francisco Solé, Armando López-Guillermo, Dolors Colomer, Louis M. Staudt, Andreas Rosenwald, German Ott, Pedro Jares, Elias Campo   +23 more
doaj   +1 more source

Immune evasion of mantle cell lymphoma: expression of B7-H1 leads to inhibited T-cell response to and killing of tumor cells

Haematologica, 2013
Clinical trials of immunotherapy in mantle cell lymphoma have not yet delivered desirable results, partly because of the inhibitory machinery of the tumor and its microenvironment.
Lijuan Wang, Jianfei Qian, Yong Lu, Haiyan Li, Hanying Bao, Donghua He, Zhiqiang Liu, Yuhuan Zheng, Jin He, Yi Li, Sattva Neelapu, Jing Yang, Larry W. Kwak, Qing Yi, Zhen Cai   +14 more
doaj   +1 more source

In situ mantle cell lymphoma: clinical implications of an incidental finding with indolent clinical behavior

Haematologica, 2012
Background Cyclin D1-positive B cells are occasionally found in the mantle zones of reactive lymphoid follicles, a condition that has been called “in situ mantle cell lymphoma”.
Alejandra Carvajal-Cuenca, Luz F. Sua, Nhora M. Silva, Stefania Pittaluga, Cristina Royo, Joo Y. Song, Rachel L. Sargent, Blanca Espinet, Fina Climent, Samuel A. Jacobs, Jan Delabie, Kikkeri N. Naresh, Adam Bagg, Pierre Brousset, Roger A. Warnke, Sergi Serrano, Nancy Lee Harris, Steven H. Swerdlow, Elaine S. Jaffe, Elías Campo   +19 more
doaj   +1 more source

Blastic transformation of mantle cell lymphoma with B-lymphoblastic features

Human Pathology: Case Reports, 2019
Mantle cell lymphoma is characterized by the presence of the t(11;14)(q13;q32), which is found in more than 95% of cases. We present a case of mantle cell lymphoma with the typical phenotype, which transformed to a blastic morphology with loss of ...
David Cantu, Yuridia Alvarado, Joyce Murata-Collins, Dennis D. Weisenburger   +3 more
doaj   +1 more source

Expression and effects of inhibition of type I insulin-like growth factor receptor tyrosine kinase in mantle cell lymphoma

Haematologica, 2011
Background Type I insulin-like growth factor receptor (IGF-IR) tyrosine kinase induces significant oncogenic effects. Strategies to block IGF-IR signaling are being tested in clinical trials that include patients with aggressive solid malignancies ...
Deeksha Vishwamitra, Ping Shi, Desiree Wilson, Roxsan Manshouri, Francisco Vega, Ellen J. Schlette, Hesham M. Amin   +6 more
doaj   +1 more source

Inhibition of focal adhesion kinase overcomes resistance of mantle cell lymphoma to ibrutinib in the bone marrow microenvironment

Haematologica, 2018
Mantle cell lymphoma and other lymphoma subtypes often spread to the bone marrow, and stromal interactions mediated by focal adhesion kinase frequently enhance survival and drug resistance of the lymphoma cells. To study the role of focal adhesion kinase
Martina Rudelius, Mathias Tillmann Rosenfeldt, Ellen Leich, Hilka Rauert-Wunderlich, Antonio Giovanni Solimando, Andreas Beilhack, German Ott, Andreas Rosenwald   +7 more
doaj   +1 more source

Recurrent Mantle Cell Lymphoma Presenting as Gastrointestinal Bleeding

Case Reports in Gastroenterology, 2018
Mantle cell lymphoma is a rare and aggressive subtype of B-cell non-Hodgkin lymphomas. Mantle cell lymphoma frequently involves extranodal sites, and gastrointestinal tract is involved microscopically and macroscopically in more than 80% of cases.
Rafeeq Ahmed, Kishore Kumar, Jasbir Makker, Masooma Niazi, Bhavna Balar   +4 more
doaj   +1 more source

Differential diagnosis of cyclin D2+ mantle cell lymphoma based on fluorescence in situ hybridization and quantitative real-time-PCR

Haematologica, 2009
Mantle cell lymphoma is characterized by the t(11;14) chromosomal translocation, resulting in the overexpression of cyclin D1 (CycD1). Recently, cases of mantle cell lymphoma negative for cycD1 but positive for cycD2 or cycD3 were identified by gene ...
Leticia Quintanilla-Martinez, Julia Slotta-Huspenina, Ina Koch, Margit Klier, Eric D. Hsi, Laurence de Leval, Wolfram Klapper, Stefan Gesk, Reiner Siebert, Falko Fend   +9 more
doaj   +1 more source

Constitutive and B-cell receptor-induced activation of STAT3 are important signaling pathways targeted by bortezomib in leukemic mantle cell lymphoma

Haematologica, 2010
Background The deregulation of several transcription factors contribute to the aggressive course of mantle cell lymphoma. This study focuses on survival signals emanating from the tumor environment and involving the signal transducer and activator of ...
Fanny Baran-Marszak, Mohand Boukhiar, Stéphanie Harel, Christelle Laguillier, Claudine Roger, Remy Gressin, Antoine Martin, Remi Fagard, Nadine Varin-Blank, Florence Ajchenbaum-Cymbalista, Dominique Ledoux   +10 more
doaj   +1 more source

Magnetic resonance imaging with pathological correlation in a case of mantle cell lymphoma of the parotid gland: a case report

Journal of Medical Case Reports, 2010
Introduction Mantle cell lymphoma is a rare non-Hodgkin's lymphoma. It is a subtype of B-cell lymphoma with frequent involvement of the bone marrow and the gastrointestinal tract. Isolated parotid gland involvement seldom occurs.
Karakozoglou Thrasivulos, Iordanidis Fotis, Athanasiadou Anastasia, Pilavaki Mayia, Palladas Panagiotis   +4 more
doaj   +1 more source