Results 61 to 70 of about 44,308 (198)
Therapeutic targeting of chromatin alterations in leukemia and solid tumors
International Journal of Cancer, EarlyView.Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner +7 more
wiley +1 more source
NF-κB signaling and its relevance to the treatment of mantle cell lymphoma
Journal of Hematology & Oncology, 2018 Mantle cell lymphoma is an aggressive subtype of non-Hodgkin B cell lymphoma that is characterized by a poor prognosis determined by Ki67 and Mantle Cell International Prognostic Index scores, but it is becoming increasingly treatable.
Swathi Balaji +5 more
doaj +1 more source
EJNMMI Research, 2020 Background In order to study the CXCR4 expression with [68Ga]pentixafor PET in different types of non-Hodgkin lymphoma, we performed a retrospective study to describe the [68Ga]pentixafor PET/CT imaging in a spectrum of lymphomas and to compare it with ...
Qingqing Pan +7 more
doaj +1 more source
Eccrine poromatosis following chemotherapy and radiation therapy [PDF]
, 2019 Eccrine poroma presents as a single, symptomless erythematous papule in areas with a high density of eccrine sweat glands. Although rare, eccrine poromas can present as multiple lesions, otherwise known as eccrine poromatosis.
Chiu, Melvin, Kim, Gene, Nguyen, Khoa
core
Perforated small intestine in a patient with T-cell lymphoma; a rare cause of peritonitis [PDF]
, 2016 The nontraumatic perforations of the small intestine are pathological entities with particular aspects in respect to diagnosis and treatment. These peculiarities derive from the nonspecific clinical expression of the peritonitis syndrome, and from the ...
Banu, Petrisor +3 more
core +3 more sources
Journal of Clinical Laboratory Analysis, EarlyView.Our study proposed a practical set of customized flow cytometry markers that enhance the diagnosis of CLL by improving both sensitivity and accuracy. Moreover, these markers hold significant prognostic value. The identification of relapse‐associated markers provides critical insights to inform personalized treatment and monitoring strategies.
Ornnicha Sathitakorn +16 more
wiley +1 more source
Rituximab-EPOCH, an effective salvage therapy for relapsed, refractory or transformed B-cell lymphomas: results of a phase II study [PDF]
, 2017 Background: Relapsed or refractory diffuse large B-cell and mantle-cell lymphoma have a poor prognosis. The EPOCH regimen and rituximab monotherapy have demonstrated activity as salvage therapies.
Betticher, D. C. +8 more
core
Antigen-driven clonal proliferation of B cells within the target tissue of an autoimmune disease: the salivary glands of patients with Sjögren's syndrome [PDF]
, 1998 Structures resembling germinal centers are seen in the salivary glands of patients with Sjögren's syndrome, but it is not known whether the microenvironment of these cell clusters is sufficient for the induction of a germinal center response.
Berek, C. +4 more
core +2 more sources
CPT: Pharmacometrics &Systems Pharmacology, EarlyView.ABSTRACT Pirtobrutinib is a reversible Bruton tyrosine kinase (BTK) inhibitor. In vitro, pirtobrutinib is metabolized by cytochrome P450 (CYP) 3A4 and uridine 5′‐diphosphoglucuronosyl transferases (UGTs) and causes reversible and time‐dependent inhibition and induction of CYP3A4.
Dan‐Dan Tian +3 more
wiley +1 more source
Hematology, Transfusion and Cell Therapy, 2018 Objective: Follicular and mantle cell lymphoma are low-grade B-cell malignancies that lack good responses to chemoimmunotherapy. This study aimed to assess retrospectively clinicopathological features and to determine independent prognostic factors for ...
Guilherme Rossi Assis-Mendonça +8 more
doaj +1 more source