Results 121 to 130 of about 147,528 (279)

Large‐cell transformation of mycosis fungoides: Patterns of care and patient outcomes

British Journal of Haematology, EarlyView.
Large‐cell transformation of mycosis fungoides is rare with poor prognosis. Presenting over 20 years of data, this retrospective study of 83 patients demonstrated a median overall survival (mOS) of 3.5 years. However, prognostic differences in three clinical subgroups were suggested: unifocal, multifocal, extra‐cutaneous (mOS: 4.6, 2.5, 1.1 years ...
Philippa Johnstone, Martin Higgins, H. Miles Prince, Stephen Lade, Chris McCormack, Carrie van der Weyden, Friyana Bhabha, Odette Buelens, Piers Blombery, Belinda A. Campbell   +9 more
wiley   +1 more source

Secondary malignancies after chronic myeloid leukaemia upon TKI treatment: Population trends and outcomes

British Journal of Haematology, EarlyView.
A retrospective study from 11 institutions was performed in 139 chronic myeloid leukaemia (CML) patients with secondary malignancies. The median ages at diagnosis of CML and secondary malignancy were 51 years (range, 13–88 years) and 53 years (range, 18–91 years). After a median follow‐up of 85 months, the median time from diagnosis of CML to secondary
Yingling Zu, Xipeng Yue, Xinrong Zhan, Xiaojuan Liu, Hongxia Ma, Fuli Qin, Lijuan Duan, Hongmian Zhao, Yan Zhang, Shiqiang He, Huifang Zhao, Chunlei Zhang, Xiangke Xin, Wenli Zhang, Yongping Song, Bingcheng Liu, Weiming Li, Yanli Zhang   +17 more
wiley   +1 more source

Cutaneous involvement in angioimmunoblastic T-cell lymphoma

Indian Journal of Dermatology, 2010
Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive non-Hodgkin′s nodal peripheral T-cell lymphoma characterized by general lymphadenopathy, night sweats, fever, hepatosplenomegaly, polyclonal hypergammaglobulinemia, and cutaneous ...
Papadavid Evangelia, Panayiotides Ioannis, Dalamaga Marianna, Katoulis Alexandros, Economopoulos Theofanis, Stavrianeas Nikolaos   +5 more
doaj  

Extranodal natural killer/T-cell lymphoma with paraneoplastic eosinophilic myositis

Human Pathology: Case Reports, 2020
Extranodal natural killer/T-cell lymphoma is a rare Epstein-Barr virus-associated aggressive lymphoma commonly involving the nasal and upper aerodigestive tract and, less commonly, extranodal sites such as skin and gastrointestinal tract.
Jayati Mallick, Jasmine Zain, Dennis D. Weisenburger   +2 more
doaj  

The impact of Foxp3+ regulatory T‐cells on CD8+ T‐cell dysfunction in tumour microenvironments and responses to immune checkpoint inhibitors

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have been a breakthrough in cancer therapy, inducing durable remissions in responding patients. However, they are associated with variable outcomes, spanning from disease hyperprogression to complete responses with the onset of immune‐related adverse events.
Mikhaël Attias, Ciriaco A. Piccirillo
wiley   +1 more source

Treatment options for immune‐related adverse events associated with immune checkpoint inhibitors

British Journal of Pharmacology, EarlyView.
Abstract The immunotherapy revolution with the use of immune checkpoint inhibitors (ICIs) started with the clinical use of the first ICI, ipilimumab, in 2011. Since then, the field of ICI therapy has rapidly expanded — with the FDA approval of 10 different ICI drugs so far and their incorporation into the therapeutic regimens of a range of malignancies.
Yu Hua Chen, Tamás Kovács, Péter Ferdinandy, Zoltán V. Varga   +3 more
wiley   +1 more source

Lymphomatoid Papulosis Following Spesolimab Treatment for Generalised Pustular Psoriasis

Australasian Journal of Dermatology, EarlyView.
Mizuho Namba, Mika Matsumoto, Naoya Saito, Atsuko Kimura, Chihiro Sagara, Daiki Rokunohe, Eijiro Akasaka   +6 more
wiley   +1 more source

GPCR‐G protein signalling and its mutational landscape in cancer—Driver or passenger

British Journal of Pharmacology, EarlyView.
G protein‐coupled receptors (GPCRs) play a crucial role in cellular signalling, regulating various physiological processes. Abnormal expression and mutations of GPCRs have been implicated in several types of cancer, influencing tumour initiation, progression and immune response.
Chenlin Feng, Jasper F. Ooms, Erik H. J. Danen, Laura H. Heitman   +3 more
wiley   +1 more source

Lichen Planus Follicularis Tumidus

Australasian Journal of Dermatology, EarlyView.
A. I. Oloruntoba, Saurabh Prakash, Ryan Toholka   +2 more
wiley   +1 more source

Upregulation of YY1/EZH2 and MLH1 as Therapeutic Targets for Adult T‐Cell Leukemia/Lymphoma

Cancer Science, EarlyView.
UMAP projection of CD4 T cells from ATLL patients specified a CD48‐deficient cluster, in which YY1 and EZH2 are upregulated. ABSTRACT The clinical and genetic presentation of adult T‐cell leukemia/lymphoma (ATLL) ranges from indolent to aggressive, making it difficult to identify common therapeutic targets.
Takuya Shimizu, Takero Shindo, Hanako Ogawa, Kaori Teranaka, Akira Watanabe, Akifumi Takaori‐Kondo   +5 more
wiley   +1 more source