Results 261 to 270 of about 187,246 (326)

Administration of nivolumab plus ipilimumab: Infusion of the fixed‐ratio combination versus sequential infusions in two randomized controlled trials of metastatic melanoma (CheckMate 742) and renal cell carcinoma (CheckMate 800)

Cancer, Volume 131, Issue 14, 15 July 2025.
Abstract Background Immune checkpoint inhibitors can be coadministered as a fixed‐ratio combination (FRC) or administered as sequential infusions (ASI). Two randomized, open‐label trials compared nivolumab + ipilimumab as a FRC versus ASI in patients with melanoma or renal cell carcinoma.
Alexander M. Menzies, Pamela Salman, Osvaldo Arén Frontera, David Pook, Christopher M. Hocking, Yousef Zakharia, Howard Gurney, Craig Gedye, Jeffrey C. Goh, Bijoy Telivala, Jean‐Jacques Grob, Céleste Lebbé, Luis de la Cruz Merino, Laurent Machet, Eve‐Marie Neidhardt, Anila Qureshi, Fareeda Hosein, Lora Hamuro, Burcin Simsek, Asim Amin   +19 more
wiley   +1 more source

JSH practical guidelines for hematological malignancies, 2023: II. lymphoma-overview. [PDF]

Int J Hematol
Ohmachi K.
europepmc   +1 more source

MS275 Inhibits Neuroblastoma Cell Growth by Mediating H3K27ac/PROX1 Axis In Silico and In Vitro

The FASEB Journal, Volume 39, Issue 13, 15 July 2025.
Our study demonstrates that MS275, a selective HDAC inhibitor, suppresses HDAC1/3 protein expression, leading to hyperacetylation of histone H3 at lysine 27 (H3K27ac) within the PROX1 promoter region (−608 to −508). This epigenetic modification upregulates PROX1 transcription, which subsequently modulates key cellular processes, including cell cycle ...
Chao Yuan, Chaoqun Li, Junwei Lu, Shengjie Liao, Runkun Wu, Duanzhuo Li, Mi Huang, Dacong Gong, Weibin Wu, Xin Yu, Shinuan Fei, Wenxia Si   +11 more
wiley   +1 more source

A mature T-cell neoplasm with features of peripheral T-cell lymphoma, not otherwise specified presenting with multiple cutaneous tumors on the scalp in a patient with long-standing lichen planopilaris. [PDF]

JAAD Case Rep
Jones BA, Hodges WT, Salehi M, Cornell G, Goyal S, Frater JL, Hurley MY.   +6 more
europepmc   +1 more source

Modified total skin electron treatment for a paraplegic patient

Journal of Applied Clinical Medical Physics, Volume 26, Issue 7, July 2025.
Abstract Total Skin Electron Therapy (TSET) has been a highly effective treatment for mycosis fungoides (MF). However, the standard TSET treatment requires the patient to stand upright in six different positions for an extended time period, which may not be possible for some patients.
Thomas Martin, Geoff Nelson, David Gaffney, Christian Dial, Martin Szegedi, Prema Rassiah   +5 more
wiley   +1 more source

Extensive Scaly Erythema with Recurring Ulcers and Crusts: A Quiz. [PDF]

Acta Derm Venereol
Zhu D, Chen B, Zhou Y.
europepmc   +1 more source

Commissioning and clinical implementation of low dose dual‐field rotational TSET

Journal of Applied Clinical Medical Physics, Volume 26, Issue 7, July 2025.
Abstract Background Total skin electron therapy (TSET) is a specialized technique for treating cutaneous T‐cell lymphomas, such as mycosis fungoides. While traditional TSET regimens prescribe 30–36 Gy, low dose TSET at 12 Gy has gained attention due to its reduced toxicity.
Broderick Ivan McCallum‐Hee, Mounir Ibrahim, Godfrey Mukwada, Pejman Rowshanfarzad, Joshua Dass, Jude Dewitt, Robert Parin, Gregory Withey, Zaid Alkhatib   +8 more
wiley   +1 more source

First‐in‐human phase 1 study of KHK2455 monotherapy and in combination with mogamulizumab in patients with advanced solid tumors

Cancer, Volume 131, Issue 13, 1 July 2025.
Abstract Background Indoleamine 2,3‐dioxygenase 1 (IDO1) is a heme‐containing enzyme that degrades tryptophan (Trp) to kynurenine (Kyn), which suppresses effector T cells and reduces antitumor activity. KHK2455 is a long‐acting selective IDO1 inhibitor that blocks the heme component of the IDO holoenzyme.
Timothy A. Yap, Olivier Rixe, Capucine Baldini, Ursa Brown‐Glaberman, Sergey Efuni, David S. Hong, Christophe Massard, Jameel Muzaffar, Andreea Varga, Emrullah Yilmaz, Yuta Ikawa, Lisa H. Shiue, Yi Liu, Matthew W. Hruska, Henry Zhao, Akihiro Tokunaga, Solmaz Sahebjam   +16 more
wiley   +1 more source

Canine lymphoma in Croatia: a fourteen-year retrospective study. [PDF]

BMC Vet Res
Eraghi V, Zagradišnik LM, Matasović M, Vlahović D, Huber D, Kurilj AG, Šoštarić-Zuckermann IC, Artuković B, Buhin IM, Ciprić I, Hohšteter M.   +10 more
europepmc   +1 more source

Sézary Syndrome—Eosinophilia Explained by a Blood Film

American Journal of Hematology, Volume 100, Issue 8, Page 1423-1424, August 2025.
Merel T. A. Soeterik, Joris Janssen, Leo M. Budel, Anton W. Langerak, Yorick Sandberg, Barbara J. Bain   +5 more
wiley   +1 more source