Results 171 to 180 of about 14,856,428 (286)

Herbal Therapeutics in Osteoporosis: Mechanisms, Evidence, and Translational Potential

open access: yesPhytotherapy Research, EarlyView.
Schematic overview of bone remodeling dysregulation in osteoporosis and the multi‐target protective role of herbal therapeutics. ABSTRACT Osteoporosis is a chronic bone disease marked by reduced density and increased fracture risk. Current treatments face limitations in safety, efficacy, and long‐term adherence, prompting interest in alternative ...
Elnaz Vafadar Moradi   +5 more
wiley   +1 more source

Copy number variation analysis of cerebrospinal fluid metagenomic next‐generation sequencing data in assisting the diagnosis of pediatric brain tumors

open access: yes
Pediatric Investigation, EarlyView.
Changhong Ren   +7 more
wiley   +1 more source

Safety and Efficacy of Direct Cryobiopsy Specimen Retrieval Through the 3.0‐mm Working Channel of a Therapeutic Bronchoscope Using a 1.1‐mm Cryoprobe: A Multicentre Prospective Observational Study

open access: yesRespirology, EarlyView.
Safety and efficacy of direct 1.1‐mm cryobiopsy specimen retrieval through a 3.0‐mm therapeutic bronchoscope channel were evaluated. The technique achieved 87.5% overall diagnostic yield, produced specimens three times larger than forceps biopsy, and caused Grade 3 bleeding in only 2.1%.
Yuki Takigawa   +13 more
wiley   +1 more source

Driving Drugs Deeper: Force‐Driven Microneedle Systems for Active Therapy and Their Road Towards Clinical Implementation

open access: yesSmall, EarlyView.
Force‐driven microneedles are presented as active therapeutic microdevices that overcome the diffusion limits of conventional patches. By integrating gas generation, magnetic actuation, cavitation, or iontophoresis, these systems drive payloads deeper into tissue, enabling faster, more controlled delivery and highlighting key design principles and ...
Majed Amini   +3 more
wiley   +1 more source

Patient cell drug profiling identifies p53-linked vulnerabilities in refractory lymphoid malignancies. [PDF]

open access: yesNPJ Precis Oncol
Cederlund A   +6 more
europepmc   +1 more source

Targeting the CD47–SIRPα phagocytic checkpoint in cancer: Biology, translational opportunities, and next‐generation therapeutic strategies

open access: yesSmart Molecules, EarlyView.
The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou   +4 more
wiley   +1 more source

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