Results 61 to 70 of about 465,548 (350)

Disseminated Gastric MALT Lymphoma with Monoclonal Gammopathy, t(11;18)(q21;q21), and Subsequent Development of T-Large Granular Lymphocytic Leukemia: A Case Report and Review of the Literature

Case Reports in Medicine, 2015
Background. Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) is a well-characterized entity that may share clinical and morphological findings with other low-grade non-Hodgkin’s lymphomas.
Riad Akoum, Wassim Serhal, Hussein Farhat   +2 more
doaj   +1 more source

HTLV 1 associated adult T cell lymphoma/leukemia a clinicopathologic, immunophenotypic tale of three cases from non-endemic region of south India

Indian Journal of Pathology and Microbiology, 2012
Adult T cell lymphoma/leukemia is a peripheral T-cell neoplasm caused by human T-cell lymphotrophic virus-1, affects mostly adults with systemic involvement and poor prognosis. Diagnosis of adult T-Cell leukemia/Lymphoma is challenging.
Faiq Ahmed, S Sudha Murthy, M. V. T. Krishna Mohan, Senthil J Rajappa   +3 more
doaj   +1 more source

Polyclonal and monoclonal B lymphocytes response in HCV-infected patients treated with direct-acting antiviral agents [PDF]

, 2017
Hepatitis C virus (HCV) chronic infection can be associated with extrahepatic manifestations such as mixed cryoglobulinaemia and lymphoproliferative disorders that are endowed with increased rates of morbidity and all-cause mortality.
Burra, Patrizia, Farinati, Fabio, Floreani, Annarosa, Fogar, Paola, Franceschet, Enrica, Gambato, Martina, Nabergoj, Mitja, Pantano, G, Piva, Elisa, Plebani, Mario, Russo, FRANCESCO PAOLO, Schiavinato, Alvise, Tosato, Francesca, Zanetto, Alberto   +13 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Successful anti-tumor effects with two novel bifunctional chemotherapeutic compounds that combine a LAT1 substrate with cytotoxic moieties in aggressive T-cell lymphomas

Leukemia Research Reports
T-cell lymphomas are aggressive neoplasms characterized by poor responses to current chemotherapeutic agents. Expression of the l-type amino acid transporter 1 (LAT 1, SLC7A5) allows for the expansion of healthy T-cell counterparts, and upregulation of ...
Carlos Murga-Zamalloa, Shaun Webb, John Reneau, Alejandro Zevallos, Pierina Danos-Diaz, Vanessa Perez-Silos, Mirna Rodriguez, Guangyao Gao, Wolf-Nicolas Fischer, Bernd Jandeleit, Ryan Wilcox   +10 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Histopathological features of peripheral T-cell lymphoma in Sprague Dawley rats induced with N-methyl-N-nitrosourea [PDF]

, 2011
This study described the histopathological features of peripheral T-cell lymphoma in male Sprague Dawley rats following intraperitoneal (i.p.) injections of N-methyl-N-nitrosourea (MNU) at a dose of 60 mg/kg body weight per injection, administered ...
Al-Salih, Hutheyfa A. H., Hamzah, Hazilawati, Mohamed Mustapha, Noordin, Sabri, Jasni, Shaari, Mohd Rosly, Sithambaram, Shanmugavelu   +5 more
core  

Peculiarities of polyneuropathy in the peripheral t-cell lymphoma with cytostatics [PDF]

, 2015
This paper presents data on the occurrence and form of polyneuropathy in the peripheral T-cell lymphoma, and its main pathogenesis elements. Here the toxic effects of cytotoxic drugs and their role in the impairment of the nervous system have been ...
Avdeeva, I. V., Gubarev, Y. D., Yatsenko, E. A.   +2 more
core   +2 more sources

Immune‐Driven Expression in Inclusion Body Myositis With T‐Cell Large Granular Lymphocytic Leukemia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives T‐cell large granular lymphocytic leukemia (T‐LGLL), reported in up to 58% of inclusion body myositis (IBM) patients, is a rare leukemia of cytotoxic or less commonly helper T cells. The range of myopathies in T‐LGLL and the impact of coexisting T‐LGLL in IBM are not well understood. Our objectives are to investigate the spectrum of
Pannathat Soontrapa, Iago Pinal‐Fernandez, Pritikanta Paul, Michael P. Skolka, Margherita Milone, Min Shi, Mithun V. Shah, Maria Casal‐Dominguez, Katherine Pak, Andrew L. Mammen, Teerin Liewluck   +10 more
wiley   +1 more source

Peripheral T-cell lymphoma: Frequency and distribution in a tertiary referral center in South India

Indian Journal of Pathology and Microbiology, 2012
Background and Aim: Peripheral T/NK-cell lymphomas are uncommon types of non-Hodgkin′s lymphoma (NHL) with a higher frequency in Far East countries as compared to the West.
Deepak K Burad, Manipadam M Therese, Sheila Nair   +2 more
doaj   +1 more source